Abstract: The present disclosure comprises a method for administering 2,3-dihydro-isoindole-1-one compound or a pharmaceutically acceptable salt, ester, solvate and/or prodrug thereof, for the treatment of hematological cancers such as acute myeloid leukemia (AML). The present disclosure further relates to reducing or inhibiting cell-proliferation which is activated by wild-type or mutated Fms-like tyrosine kinase-3 receptor (FLT3). The present disclosure further relates to a method of inhibiting or reducing abnormal (e.g., overexpressed) wild-type or mutated BTK activity or expression in a subject in need thereof.

Abstract: The invention relates to solid forms of 2-indolyl imidazo[4,5-D]phenanthroline, methods of their preparation, pharmaceutical compositions thereof and methods of their use.

Abstract: The present invention relates to a method of preventing, reducing, or treating cancer in a subject, comprising administering a therapeutically effective amount of or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate (including metal chelates, such as iron, zinc and others) thereof to the subject, wherein the subject has a mutation in a DNA repair gene.

Abstract: The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the CDX2-KLF4 signaling pathway to treat myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukaemia (ATLL), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the CDX2-KLF4 signaling pathway.

Abstract: Double stranded mRNA, e.g., produced in vitro, as well as method of making and using the ds mRNA, are provided.

Abstract: Double stranded mRNA (ds mRNA), e.g., produced in vitro, where one strand encodes a protein of interest and the other strand is hydrogen bonded to at least a portion of the coding region for the protein, as well as methods of making and using the ds mRNA, are provided.

Abstract: The present inventive concept contemplates a method of linking remote players in competitive play by retrieving skill metrics of a player and determining whether the skill metrics of the player rises above a minimum skill threshold for a competitive event. Responsive to determining that the skill metrics of potential player rises above the minimum skill threshold for the competitive event, the method contemplates sending the potential player a communication, such as an invitation to the competitive event and/or a promotional communication.

Abstract: The present disclosure comprises a method for administering 2,3-dihydro-isoindole-1-one compound or a pharmaceutically acceptable salt, ester, solvate and/or prodrug thereof, alone or in combination with an anticancer agent, for the treatment of hematological cancers such as acute myeloid leukemia (AML). The present disclosure further relates to reducing or inhibiting mutated IDH1 activity in a subject.

Abstract: The present invention relates to a method of preventing, reducing, or treating cancer in a subject, comprising administering a therapeutically effective amount of or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate (including metal chelates, such as iron, zinc and others) thereof to the subject, wherein the subject has a mutation in a DNA repair gene.

Abstract: Double stranded mRNA. e.g., produced in vitro, as well as method of making and using the ds mRNA, are provided.

Abstract: The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the CDX2-KLF4 signaling pathway to treat myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukaemia (ATLL), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the CDX2-KLF4 signaling pathway.

Abstract: A leveling tool useful for determining levelness with multiple inclinations is disclosed herein. The leveling tool includes a level frame having four flat exterior faces able to be placed against a workpiece, four transparent reservoirs containing fluid and air, and magnets integrated within the level frame. The reservoirs are oriented at angles of zero, thirty, forty-five, and ninety degrees relative to one of the exterior faces, respectively. This variety of exterior faces and angled reservoirs allows the reservoirs to be used to indicate level of a workpiece if the workpiece is oriented at any summation of zero, thirty, forty-five, and ninety degrees of level. The magnets within the level frame allows the level frame to be removably coupled to a ferrous workpiece.

Abstract: The present disclosure comprises a method for administering 2,3-dihydro-isoindole-1-one compound or a pharmaceutically acceptable salt, ester, solvate and/or prodrug thereof, for the treatment of hematological cancers such as acute myeloid leukemia (AML). The present disclosure further relates to reducing or inhibiting cell-proliferation which is activated by wild-type or mutated Fms-like tyrosine kinase-3 receptor (FLT3). The present disclosure further relates to a method of inhibiting or reducing abnormal (e.g., overexpressed) wild-type or mutated BTK activity or expression in a subject in need thereof.

Abstract: A multiple target electronic dart gaming machine includes multiple targets mounted on opposite sides of a game board of a target assembly that is housed in a cabinet of the gaming machine. A visual display video monitor provides players and observers with game scores and the like. The game board may be axially rotated between at least first and second positions so as to allow game play on the different targets which can be moved into and out of position to aid in gameplay such as deciding which player goes first. Additionally, the position of the game board may be detected through the use of a detector on or in the board.

Abstract: A multiple target electronic dart gaming machine includes multiple targets mounted on opposite sides of a game board of a target assembly that is housed in a cabinet of the gaming machine. A visual display video monitor provides players and observers with game scores and the like. The game board may be axially rotated between at least first and second positions so as to allow game play on the different targets which can be moved into and out of position to aid in gameplay such as deciding which player goes first. Additionally, the position of the game board may be detected through the use of a detector on or in the board.

Abstract: The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the CDX2-KLF4 signaling pathway to treat myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukaemia (ATLL), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the CDX2-KLF4 signaling pathway.

Abstract: The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the CDX2-KLF4 signaling pathway to treat myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukaemia (ATLL), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the CDX2-KLF4 signaling pathway.

Abstract: The present invention relates to compositions, biomarkers, and their use in treatment of cancer. In some embodiments, the invention relates to the use of several biomarkers in methods for determining the responsiveness of a human subject to a specific compound, methods for monitoring the efficacy of the compound, or methods for treating a human subject.

Abstract: The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the CDX2-KLF4 signaling pathway to treat myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukaemia (ATLL), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the CDX2-KLF4 signaling pathway.