Abstract: A system for a dart-based golf game on an electronic dart game machine has been developed that includes at least one electronic dart board having distinct scoring segments, a CPU electrically connected to the electronic dart board, and a video display electrically connected to the CPU. The CPU displays game mode graphics on the video display, including a golf course hole graphic having a virtual ball and a hole, and a power meter having a moving element. The CPU correlates an instantaneous movement of said moving element at an instant of the dart contact with a movement of the virtual ball on the golf course hole graphic.

Abstract: Disclosed are improved compositions and methods for use in gene delivery and expression. A range of surprisingly effective cross-linking agents and peptides are provided, as are peptide-DNA carrier compositions and condensed particles with reduced toxicity and increased stability. Advantageous methods of using such compositions in gene delivery and gene expression are further disclosed, which may be used in combination with biocompatible matrices, carriers and/or targeting agents.

Abstract: This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.

Abstract: A method is disclosed for initiating game play on a pay-for-play parlor game, such as a pool table having a playing surface, rails, pockets, a ball holding rack that retains pool balls, and an internal activation-sensing unit. The method includes depositing a game play fee into a remote activation assembly, remotely transmitting an activation signal once the game play fee is deposited, receiving the activation signal at the internal activation-sensing unit, and providing access to the pool balls upon said receiving step. A method is also disclosed for automatically scoring a pool-based game including detecting detectable devices embedded within the pool balls.

Abstract: This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.

Abstract: A portable detection system (10) for hazardous materials including explosives and infectious or hazardous biological agents readily adapted to conventional mail collection boxes (12), rural mailboxes (100) and the like. The system includes a fan (14) and a sensor (16). The fan (14) provides sufficient airflow to circulate the air within a mailbox such that the internal air after coming in contact with the contents is directed the sensor for analysis. The air quality can be determined visually (137), audibly (138), or electronically (139). Consequently once such detection is made and the air is verified as being safe, the contents can be removed safely. If it is determined that the air contains some type of hazardous material, further steps can be taken to specifically locate the source of such hazardous material. An alternative embodiment includes a filter (15) to improve fan efficiency. The system is further adaptable to other mail container embodiments such as a mailbag (40).

Abstract: Methods for elucidating an antifungal or anti-yeast compound which selectively bind to a fungal or yeast zinc finger-containing protein within a fungus are disclosed. Assays of screening for compounds that are effective for binding to a fungal or yeast zinc finger-containing protein are also provided. It is also provided a pharmaceutical composition containing an effective amount of a compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods. Fungal and/or yeast infections can be treated or prevented by administering to a patient in need of treatment the pharmaceutical composition containing an effective amount of an compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods.

Abstract: Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.

Abstract: The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labeled HIV-1 psi-site oligonucleotide and an amount of the molecule to be tested under binding conditions; and determining the amount of oligonucleotide bound to the NCp7 polypeptide, wherein a decrease in the amount of oligonucleotide bound in the presence of the molecule compared with the amount of oligonucleotide bound in the absence of the molecule indicates that the molecule inhibits binding of NCp7 polypeptide to the oligonucleotide.

Abstract: Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

Abstract: Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

Abstract: A method and system for inspecting ophthalmic lenses using absorption where an ophthalmic lens is illuminated with light comprising wavelengths that are substantially absorptive to said lens, the image subsequently detected being created using only light at said absorptive wavelengths. Variations in transmitted light intensity translate into thickness changes in the lens caused by cosmetic flaws. The invention is also directed to imaging lens assemblies employing highly positive-powered field flattening lens elements to image a curved object, such as an ophthalmic lens, onto a flat image plane.

Abstract: Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.

Abstract: The invention provides correction of wavefront aberrations of the eye that take into account fluctuations in the aberrations due to biophysical rhythms. Correction is provided for an intermediate value of these fluctuations of the wavefront aberrations. This intermediate value is determined by extrapolating a wavefront measurement to predict the overall variation. The final correction is determined using a weighting scheme derived from the clinical comparisons of the frequency and amplitude components of the variations.

Abstract: The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. wherein R1 and R2 are independently —H, —OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X′ are independently —N or —NO2; Y and Y′ are independently —N or —CH, or —H; and the double-slash represents a double bond or no bond.

Abstract: The design, synthesis and antiviral activity of certain antiviral compounds are disclosed examples of which are shown below. These compounds inhibit the reverse transcriptase enzymes of several retroviruses, including human immunodeficiency virus.

Abstract: A system for a dart-based golf game on an electronic dart game machine has been developed that includes at least one electronic dart board having distinct scoring segments, a CPU electrically connected to the electronic dart board, and a video display electrically connected to the CPU. The CPU displays game mode graphics on the video display, including a golf course hole graphic having a virtual ball and a hole, and a power meter having a moving element. The CPU correlates an instantaneous movement of said moving element at an instant of the dart contact with a movement of the virtual ball on the golf course hole graphic.

Abstract: Certain embodiments of the present invention provide an electronic dart game machine comprising a dart board and a central processing unit (CPU). The dart board has distinct scoring areas. The central processing unit (CPU) interprets dart contact with the distinct scoring areas as game set-up information during a game set-up mode.

Abstract: A method and system for inspecting ophthalmic lenses using absorption where an ophthalmic lens is illuminated with light comprising wavelengths that are substantially absorptive to said lens, the image subsequently detected being created using only light at said absorptive wavelengths. Variations in transmitted light intensity translate into thickness changes in the lens caused by cosmetic flaws. The invention is also directed to imaging lens assemblies employing highly positive-powered field flattening lens elements to image a curved object, such as an ophthalmic lens, onto a flat image plane.

Abstract: A combination entertainment system for providing both jukebox and game entertainment is disclosed. The entertainment system comprises a jukebox subsystem, a dart game subsystem, and a control subsystem that coordinates a jukebox mode of operation and a dart game mode of operation. Also disclosed is a method of operation for the combination jukebox and game entertainment system. The method transfers operation between game, jukebox, and advertisement modes of operation, based on patron input and the current operating mode of the system.