Abstract: A semiconductor structure includes providing a substrate including a first surface and a second surface opposite to the first surface. The first surface is a functional surface. The method also includes forming a plastic seal layer on the first surface of the substrate, and performing a thinning-down process on the second surface of the substrate after forming the plastic seal layer. The plastic seal layer provides support for the substrate during the thinning-down process, and thus warping or cracking of the plastic seal layer 240 may be avoided. In addition, the plastic seal layer can also be used as a material for packaging the substrate. Therefore, after the thinning-down process, the plastic seal layer does not need to be removed. As such, the fabrication process is simplified, and the production cost is reduced.

Abstract: Disclosed is a state reporting control method, which is applied to a stateful path computation element and includes: setting and notifying an initial subscription state of an LSP state report of a PCC node in a process of session initialization with the PCC node; and sending a subscription update request to the PCC node to subscribe or unsubscribe the LSP state report of the PCC node.

Abstract: A packaging structure and a method for fabricating the packaging structure are provided. The method includes providing a wafer. The wafer has a first surface and a second surface opposing to the first surface, and the wafer includes a plurality of first chip regions and a spacing region between adjacent first chip regions. The method also includes forming a first adhesive layer adhered to the second surface of the wafer, and forming an opening penetrating through the spacing region of the wafer and a plurality of first chips in the first chip regions on sides of the opening. Further, the method includes forming a molding layer in the opening. The molding layer covers a sidewall of the first chip and exposes a top surface of the first chip.

Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering the treatment compound to the subject having the cancer; obtaining a sample from the subject; determining the level of a biomarker in the sample from the subject; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the sample of the subject changes as compared to a reference level of the biomarker; wherein the treatment compound is a compound of Formula I:

Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering the treatment compound to the subject having the cancer; obtaining a sample from the subject; determining the level of a biomarker in the sample from the subject; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the sample of the subject changes as compared to a reference level of the biomarker; wherein the treatment compound is Compound 1, Compound 2, or Compound 3.

Abstract: The present document discloses a method and a system for restoring an optical layer service. The method includes: determining wavelength resource occupancy information of an inner-link of the node and an optical layer link where the node is located; herein the wavelength resource occupancy information includes resource occupancy state information of a wavelength resource corresponding to a Hold Priority; and flooding the wavelength resource occupancy information in a network where the node is located.

Abstract: The document discloses a method for invoking a routing algorithm, an SDN-OAF, and an SDN controller. The method includes pre-configuring a customized routing algorithm; an SDN controller receiving a path computation request from an application, invoking a corresponding customized routing algorithm according to information about the customized routing algorithm carried in the path computation request to compute a service path.

Abstract: A method for acquiring a cross-domain separation path includes: when receiving a cross-domain separation path computation request, acquiring K pairs of candidate separation domain sequences according to a cross-domain network abstraction topology; traversing the K pairs of sequences, generating corresponding intra-domain path computation requests for various domains through which candidate separation domain sequences in the network pass to transmit; when receiving at least one pair of intra-domain paths for the request, configuring each of the at least one pair of intra-domain paths to a corresponding position in the K pairs of sequences, to form K pairs of candidate cross-domain separation paths; and determining one pair of cross-domain separation paths from the K pairs of paths as a computation result of the cross-domain separation path computation request to transmit.

Abstract: A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.

Abstract: Provided herein are methods of treating, preventing, managing, and/or ameliorating leukemia or myelodysplastic syndrome comprising administering 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, an isotopologue, pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof to a patient.

Abstract: Provided herein are methods of treating, preventing, managing, and/or ameliorating leukemia or myelodysplastic syndrome comprising administering 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, an isotopologue, pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof to a patient.

Abstract: A packaging structure and a method for fabricating the packaging structure are provided. The method includes providing a wafer. The wafer has a first surface and a second surface opposing to the first surface, and the wafer includes a plurality of first chip regions and a spacing region between adjacent first chip regions. The method also includes forming a first adhesive layer adhered to the second surface of the wafer, and forming an opening penetrating through the spacing region of the wafer and a plurality of first chips in the first chip regions on sides of the opening. Further, the method includes forming a molding layer in the opening. The molding layer covers a sidewall of the first chip and exposes a top surface of the first chip.

Abstract: Provided herein are formulations and methods of use of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Abstract: Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.

Abstract: A resource processing method, an operating system, and a device are provided. The method is applied to a multi-core operating system, where the multi-core operating system includes a management operating system and multiple load operating systems that run on a host machine and includes a physical resource pool. According to the method, after selecting, in processor cores allocated to a first load operating system, a startup processor core that starts up the first load operating system, the management operating system instructs the startup processor core to read a mapping relationship that is from a virtual memory address to a physical memory address and that is required for executing a startup mirror of the first load operating system. Then, the management operating system instructs the startup processor core to execute the startup mirror pre-constructed for the first load operating system to start up the first load operating system.

Abstract: Disclosed are a path computation method and a path computation element, applied to a system including two or more path computation elements (PCEs), and in the system, one of the PCEs is a primary PCE, and the other PCEs are secondary PCEs; the method includes: the primary PCE, after receiving a path computation request sent by a path computation client (PCC), selecting one PCE in the system to be the PCE processing this path computation request, and the selected PCE processing the path computation request. When a PCE works as the primary PCE, the PCE includes: a receiving module, configured to receive a path computation request sent by a PCC; a selecting module, configured to select one PCE in the system to be the PCE processing this path computation request after the receiving module receives the path computation request.

Abstract: A semiconductor structure includes providing a substrate including a first surface and a second surface opposite to the first surface. The first surface is a functional surface. The method also includes forming a plastic seal layer on the first surface of the substrate, and performing a thinning-down process on the second surface of the substrate after forming the plastic seal layer. The plastic seal layer provides support for the substrate during the thinning-down process, and thus warping or cracking of the plastic seal layer 240 may be avoided. In addition, the plastic seal layer can also be used as a material for packaging the substrate. Therefore, after the thinning-down process, the plastic seal layer does not need to be removed. As such, the fabrication process is simplified, and the production cost is reduced.

Abstract: A method and an apparatus for hot standby of controllers in distributed protection are provided. In some embodiments, the method includes: through an actuator, receiving a message transmitted from each of the controllers; determining the messages transmitted in response to a same fault according to a serial number of each message, maintaining a master-standby relationship of each of the controllers through the messages transmitted in response to the same fault; and executing a corresponding operation according to a message transmitted from a master controller; and in a protocol steady state, performing a master-standby switching if it is determined that a switching condition is met.

Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering the treatment compound to a subject having cancer; obtaining a sample from the subject; determining the level of a biomarker in the sample from the subject; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the sample of the subject changes as compared to a reference level of the biomarker; wherein the treatment compound is a compound of Formula (I):

Abstract: Disclosed is a state reporting control method, which is applied to a stateful path computation element and includes: setting and notifying an initial subscription state of an LSP state report of a PCC node in a process of session initialization with the PCC node; and sending a subscription update request to the PCC node to subscribe or unsubscribe the LSP state report of the PCC node.