Abstract: A pixel circuit and a driving method therefor, a display substrate, and a display apparatus. The pixel circuit includes a driving sub circuit, a data writing sub circuit, a first light-emitting control sub circuit, a first reset sub circuit, and a bias sub circuit; the first reset sub circuit is connected to a first node and configured to write a first reset voltage to the first node in response to a first reset control signal; and the bias sub circuit is connected to a second node and configured to write a reference voltage to the second node in response to a bias control signal, thereby turning on the driving sub circuit.

Abstract: A method for growing bulk boron arsenide (BA) crystals, the method comprising utilizing a seeded chemical vapor transport (CVT) growth mechanism to produce single BAs crystals which are used for further CVT growth, wherein a sparsity of nucleation centers is controlled during the further CVT growth. Also disclosed are bulk BAs crystals produced via the method.

Abstract: The present disclosure provides a pixel driving circuit and a display panel. The pixel drive circuit includes: a data writing sub-circuit, a threshold compensation sub-circuit, a driving sub-circuit and a storage sub-circuit, the data writing sub-circuit includes a fourth transistor, which includes a first electrode connected with a data line, a second electrode connected with a first terminal of the driving sub-circuit, and a control electrode connected with a first scan signal line, and the fourth transistor is an oxide thin film transistor; the threshold compensation sub-circuit is configured to compensate a threshold voltage of the driving sub-circuit in response to a second scan signal; the storage sub-circuit is configured to store a data voltage signal; the driving sub-circuit is configured to provide a driving current for a light emitting device to be driven according to voltages of the first terminal and a control terminal thereof.

Abstract: Provided in the present invention are a lower-back supporting apparatus, a backrest supporting frame, and a seating unit. The lower-back supporting apparatus includes a lower-back supporting plate; a lower mounting plate; two supporting structures, provided between the lower-back supporting plate and the lower mounting plate, hinged to the lower-back supporting plate and the lower mounting plate, respectively; and an extendable and retractable part, including an extendable and retractable end hinged to the lower-back supporting plate or the supporting structure, so as to drive the lower-back supporting plate away or close to the lower mounting plate.

Abstract: The present disclosure relates to a mechanical extension apparatus for an extendable chair unit and a chair unit including such mechanical extension apparatus. The mechanical extension apparatus includes: a reclining apparatus that include multiple links attached to the seat, the backrest and the footrest of the extendable seat, and such reclining apparatus is configured to convert the extendable seat between a sitting position and a lying position. The mechanical extension apparatus also includes an actuator that is attached to the reclining apparatus, and the actuator is configured to electronically convert the extendable seat between the sitting position and the lying position.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: An optoelectrical assembly includes a voltage conversion circuit, an optoelectrical semiconductor device, an optoelectrical detection circuit, and a controller. The voltage conversion circuit provides a bias voltage to the optoelectrical semiconductor device, and adjusts, by changing the bias voltage, an output optical power. A differential resistance value (Rdiff) of the optoelectrical semiconductor device within a range of a target optical power satisfies 0.1 ohm (?)?Rdiff?50?, and the differential resistance value is a ratio of a voltage variation to a current variation corresponding to the voltage variation. The optoelectrical detection circuit detects the output optical power, and outputs a detection signal to the controller. The controller determines a control signal based on the detection signal, and outputs the control signal to the voltage conversion circuit, where the control signal is used to adjust the bias voltage.

Abstract: An integrated circuit (IC) device comprises a substrate comprising a glass core. The glass core includes a first surface, a second surface opposite the first surface, a sidewall between the first surface and the second surface, and a corner region where the first sidewall meets the first surface. A first build-up layer is on at least the first surface. In some embodiments, the corner region comprises a recess and a dielectric material within the recess. In other embodiments, the corner region comprises a first compressive stress and the glass core comprises a second region. The second region comprises a second compressive stress. The first compressive stress is greater than the second compressive stress.

Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.

Abstract: The present invention relates to a scalable multiplex PCR method that can simultaneously amplify overlapping amplicons without the drawbacks of conventional multiplex PCR. The method selectively amplifying target nucleic acid fragments having an overlapping region. The method comprises the steps of: obtaining a first nucleic acid sequence comprising a first tag t2 and a first forward primer F1, obtaining a second nucleic acid sequence comprising a second tag t1 and a first reverse primer R1, obtaining a third nucleic acid sequence comprising the second tag t1 and a second forward primer F2, obtaining a fourth nucleic acid sequence comprising a third tag 3 and a second reverse primer R2, wherein each primer is a gene-specific primer; performing initial cycles of PCR; and then performing later cycles of PCR at higher annealing temperatures to obtain amplification products.

Abstract: The present disclosure relates to a mechanical extension apparatus for an extendable chair unit and a chair unit including such mechanical extension apparatus. The mechanical extension apparatus includes: a reclining apparatus that include multiple links attached to the seat, the backrest and the footrest of the extendable seat, and such reclining apparatus is configured to convert the extendable seat between a sitting position, a TV position, and a lying position. The mechanical extension apparatus also includes an actuator that is attached to the reclining apparatus, and the actuator is configured to electronically convert the extendable seat between the sitting position and the TV position; and the reclining apparatus is configured to convert the extendable seat between the TV position and the lying position by non-electric actuation.

Abstract: The present invention is directed to a method for detecting somatic mutation in cell free total nucleic acid (cfTNA) in a liquid biological sample by a personalized approach with high sensitivity and specificity. The present invention relates to multiplex amplification of target loci with primers selected from a primer bank for cancer liquid biopsies, including but not limited to minimal residual disease (MRD) monitoring, recurrence monitoring, therapy monitoring, early detecting or screening cancer. Somatic, clonal variants of a patient are first identified by sequencing of the primary tumor and the matched normal sample in the patient. Then customized panel of primer pairs for the patient is selected from a primer bank. Using the selected panel of primer pairs, multiplex polymerase chain reaction and next-generation sequencing are performed on the cfTNA sample from this patient to detect the presence of tumor DNA in the sample.

Abstract: Implementations relate to causing a command to be executed based on an image. In some implementations, a computer-implemented method includes obtaining and programmatically analyzing an image to determine suggested actions. The method causes a user interface to be displayed that includes user interface elements corresponding to default actions, and to suggested actions that are determined based on analyzing the image. The method receives user input indicative of selection of a particular action from the default actions and the suggested actions. The method causes a command to be executed by a computing device for the particular action that was selected.

Abstract: The present disclosure relates to a mechanical extension apparatus for an extendable chair unit and a chair unit including such mechanical extension apparatus. The mechanical extension apparatus includes: a reclining apparatus that include multiple links attached to the seat, the backrest and the footrest of the extendable seat, and such reclining apparatus is configured to convert the extendable seat between a sitting position, a TV position, and a lying position. The mechanical extension apparatus also includes an actuator that is attached to the reclining apparatus, and the actuator is configured to electronically convert the extendable seat between the sitting position and the TV position; and the reclining apparatus is configured to convert the extendable seat between the TV position and the lying position by non-electric actuation.

Abstract: A welding-rolling integrated composite forming method uses the low heat input wire filling welding method to cooperate with the optimization of the welding process, and at the same time the rolling device is used to roll the weld reinforcement area of the welded joint, realizing the precise control of the structure and properties of each area of the welded joint by using the plastic flow and deformation strengthening effect of the weld reinforcement of the welded joint during rolling process. The integrated composite forming device adjusts the distances between the welding mechanism, the rolling mechanism and the metal sheet to-be-welded and rolled by the coordination of each mechanism, and carries out synchronous rolling on the weld reinforcement of the welded joint.

Abstract: In a fault processing method, when it is determined that a computer crashes, a baseboard management controller in the computer can send a read request message to a processor in the computer, where the read request message is used for requesting reading of first error data recorded by the processor, receive a read response message returned by the processor, and obtain, according to the read response message, the first error data recorded by the processor.

Abstract: The present invention relates to a scalable multiplex PCR method that can simultaneously amplify overlapping amplicons without the drawbacks of conventional multiplex PCR. The method selectively amplifying target nucleic acid fragments having an overlapping region. The method comprises the steps of: obtaining a first nucleic acid sequence comprising a first tag t2 and a first forward primer F1, obtaining a second nucleic acid sequence comprising a second tag t1 and a first reverse primer R1, obtaining a third nucleic acid sequence comprising the second tag t1 and a second forward primer F2, obtaining a fourth nucleic acid sequence comprising a third tag 3 and a second reverse primer R2, wherein each primer is a gene-specific primer; performing initial cycles of PCR; and then performing later cycles of PCR at higher annealing temperatures to obtain amplification products.

Abstract: A gas shielded triple-wire indirect arc welding device has three welding wires and the two arc power supplies. In a gas shielded triple-wire indirect arc welding method, before welding, one of three welding wires is first connected to positive electrodes of a first arc power supply and a second arc power supply, the other two welding wires are respectively connected to negative electrodes of the first arc power supply and the second arc power supply, and a welding workpiece is not connected to the arc power supplies. The welding wire connected to the positive electrodes of the two arc power supplies are arranged in the middle, and the other two welding wires are respectively arranged on both sides. The welding method is used for implementing build-up welding.

Abstract: A memory fault detection method includes: receiving a first interrupt signal sent when a count value of a first leaky bucket counter of a server reaches a first threshold; disabling an interrupt switch of the first leaky bucket counter; enabling the interrupt switch of the first leaky bucket counter after the interrupt switch of the first leaky bucket counter has been disabled for a preset time and the count value of the first leaky bucket counter is reset to zero; receiving a second interrupt signal sent when a count value of a second leaky bucket counter reaches a second threshold; if the second leaky bucket counter and the first leaky bucket counter are a same leaky bucket counter, and the second rank and a first rank are a same rank, determining that a hardware fault occurs in the first rank.

Abstract: The invention includes a chimeric antigen receptor (CAR) specific for a natural-killer group 2, member D ligand (NKG2DL), compositions comprising the CAR, polynucleotides encoding the CAR, vectors comprising a polynucleotide encoding the CAR, and recombinant T cells comprising the CAR. The invention also includes methods of making a genetically modified T cell expressing a NKG2D-CAR wherein the expressed CAR comprises a NKG2D extracellular domain. The present invention also relates generally to the use of T cells engineered to express a CAR to treat cancer associated with NKG2D.