Publication number: 20200353076
Abstract: The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. The variable light chains are those of trastuzumab. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods. The antibody conjugates comprise a non-natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC-S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-S136, HC-S25, HC-A40, HC-S119, HC-S190, HC-K222, HC-R19, HC-Y52, or HC-S70, according to the Kabat, Chothia, or EU numbering scheme.
Type:
Application
Filed:
September 17, 2018
Publication date:
November 12, 2020
Inventors:
Ryan STAFFORD, Alice YAM, Xiaofan LI, Gang YIN, Toni KLINE, Cristina ABRAHAMS, Venita DE ALMEIDA
Patent number: 10689828
Abstract: The present application discloses a dredging system for a pre-paved gravel foundation bed surface in open sea deep water, including a dredging mechanism, which includes a dredging suction head, a power component and a dredging pipeline, wherein the dredging suction head is connected with the dredging pipeline; the dredging pipeline is communicated with the power component; the dredging suction head includes at least one ridge surface suction port and at least one furrow suction port; the openings of all the furrow suction ports are lower than those of all the ridge surface suction ports; a lifting mechanism, which is connected with the dredging suction head and is used for lifting the dredging suction head to the gravel foundation bed surface; a moving mechanism, which is connected with the lifting mechanism and is used for driving the dredging suction head to move within a dredging range of the gravel foundation bed surface.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
June 23, 2020
Assignees:
Shanghai Zhenhua Heavy Industries Co., Ltd., No. 2 Engineering Co. of CCCC First Harbor Engineering Co., Ltd.
Inventors:
Ming Lin, Xuejun Wang, Gang Yin, Linlin Yuan, Faqiang Su, Hong Xiang, Bin Xie, Dejin Liu, Bo Meng, Wei Xu, Zengjun Li, Jianjun Zhang, Jinbao Liu, Xiangwei Zhang, Xiangrong Zhou, Mingxiang Wang, Hongbo Wei, Chunfeng Zhu, Ziyang Bi, Jiangwei Song, Zhenjie Tao, Ling Zhu