Abstract: The present disclosure relates to a wood article and a process for preparing the wood article. In particular, the present disclosure relates to a wood article comprising a wood substrate comprising acidic substances and having at least one major surface; an adhesion promoting layer directly applied on the major surface of the wood substrate; and a Michael Addition curing coating applied on the adhesion promoting layer, wherein the adhesion promoting layer is formed by a composition comprising a functional silane comprising amino and/or imino functional groups; and wherein the Michael Addition curing coating is formed from a two-component curable coating composition.

Abstract: A compound represented by formula I, a racemate, a stereoisomer, a tautomer, a solvate, a polymorph, or a pharmaceutically acceptable salt thereof are provided. In formula I, R2 and R4 are independently selected from H or D, respectively; R1 and R3 are independently selected from CH3, CH2D, CHD2 or CD3, respectively; and the compound of formula I contains at least one deuterium atom. While retaining the pharmacological activity of the allopregnanolone, an allopregnanolone derivative that is suitable for oral administration is obtained by means of the structural modification on the hydroxyl group of the allopregnanolone.

Abstract: The present disclosure provides PROTAC compounds represented by Formula (A): D-L-DSM (A), or an enantiomer, a diastereoisomer, and/or a pharmaceutically acceptable salt of any one of the foregoing, wherein: DSM is a degradation signaling compound {e.g., an E3 ubiquitin ligase recruitment ligand, such as a CRBN ligand or a VHL ligand) covalently attached to a linker L; L is a linker that covalently attaches DSM to D; and D is a Bcl-xL inhibitor compound of Formula (I) or Formula (II) covalently attached to the linker L: (I); (II) wherein the definitions for the variables are described herein. Also provided are pharmaceutical compositions comprising the PROTAC compounds of the present disclosure and methods of use and methods of making thereof.

Abstract: A method for regulating an ILK signaling pathway in a cell, includes administering to the cell exosomes derived from mesenchymal stem cells, in particular mesenchymal stem cells derived from induced pluripotent stem cells. A method is provided for treating ILK signaling pathway related diseases using the exosomes. A pharmaceutical composition is provided for treating ILK signaling pathway related diseases, and includes exosomes derived from mesenchymal stem cells.

Abstract: Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

Abstract: The embodiments of the present disclosure provide a display substrate, a display panel, and a display device. The display substrate includes: a first base substrate, wherein a plurality of sub-pixel regions arranged in an array are provided on the first base substrate; and a reflective layer provided on one side of the first base substrate, wherein a surface of the reflective layer away from the first base substrate is formed to include a plurality of first bumps and a plurality of second bumps, and the first bump has a size greater than that of the second bump.

Abstract: The present disclosure provides a voice interaction system, a voice interaction method, and a smart device. The system includes: a voice interaction unit, a photoelectric sensing unit, and an instruction control unit configured to determine whether the voice interaction unit is in an on state, determine, when the voice interaction unit is in the on state, whether the voice interaction unit receives a target voice instruction within a predetermined time; control, when the target voice instruction is received within the predetermined time, a smart device to perform an action corresponding to the target voice instruction according to the target voice instruction of the user received and identified by the voice interaction unit; and send, when the voice instruction is not received within the predetermined time, a standby instruction to the voice interaction unit.

Abstract: The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

Abstract: A gas-fired steam-injection boiler has a flue and a water supply pipeline. The flue is provided with a radiation section and a convection section. The water supply pipeline has, in the flue gas flow direction, a first pipe section located at an upstream portion of the convection section, a second pipe section is located at a downstream portion of the convection section, and a third pipe section arranged between the first pipe section and the second pipe section. In a water flow direction of the water supply pipeline, the second pipe section, the first pipe section and the third pipe section are arranged in sequence. By using a flue gas condenser, the temperature of flue gas can be further reduced, and the latent heat of vaporization of steam in the flue gas is absorbed to form condensate water.

Abstract: Binding molecules are provided. The binding molecules specifically bind to CD16a (Fc?RIIIA) expressed on the surface of natural killer (NK) cells, but do not bind to CD16b (Fc?RIIIB). The use of such binding molecules in the stimulation and activation of primary human NK cells is also disclosed.

Abstract: Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

Abstract: Smile treatment planning systems and methods are described herein. One method for adjusting an image of a smile may generally comprise receiving a three-dimensional (3D) digital model of a dental arch of a patient, receiving a digital facial image of the patient which includes an image of one or more teeth of the patient when smiling, registering the 3D digital model to the one or more teeth of the patient from the digital facial image, correcting the 3D digital model for scale and distortion to create a corrected 3D digital model, and overlaying the corrected 3D digital model onto the digital facial image.

Abstract: Disclosed herein are systems, methods and devices for controlling output of a storage device during read operations. The method comprises: measuring a length of a temporal gap between first and second consecutive read bursts from a storage device, the first and second read burst are in response to first and second read commands received by the storage device, respectively; generating a state code according to the length, wherein the state code has a first value when the length is zero, a second value when the length is equal to or shorter than a threshold time length but is non-zero, and a third value when the length is greater than the threshold time length; and controlling output of the storage device according to the state code.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

Abstract: The rotation shaft structure includes a main shaft assembly, and two folding assemblies that are symmetrically disposed with respect to the main shaft assembly. The two folding assemblies may rotate toward or against each other relative to the main shaft assembly. When the folding assembly is specifically disposed, the folding assembly includes a rotation assembly, a support plate, and a housing mounting bracket. The rotation assembly is rotationally connected to the main shaft assembly. The support plate is rotationally connected to the housing mounting bracket and slidably connected to the rotation assembly.

Abstract: A peptide compound targeting a PD-1 receptor includes: a compound 1, a compound 2, a compound 3, a compound 4 and a compound 5; wherein the compounds 1-5 comprise amino acid sequences identical to SEQ ID NO: 1-5, respectively. A method for preparing the peptide compound targeting the PD-1 receptor includes steps of: using a solid-phase synthesis method for coupling amino acids of the compounds 1-5 to a solid-phase resin sequentially according to peptide sequences, and obtaining a target compound after cleavage by a cutting reagent, freeze-drying, and preparative purification. A method for preparing analgesic drugs includes using the peptide compound targeting the PD-1 receptor. The compounds 1-5 are capable of binding to PD-1, and have significant inhibitory effects on inflammatory pain and visceral pain under intrathecal administration; they are simple to synthesize, easy to be purified, and conducive to large-scale synthesis.

Abstract: The present disclosure provides a coil structure for generating plasma and semiconductor processing equipment. The coil structure includes at least one coil set. The coil set includes a first sub-coil set and a second sub-coil set that are coaxially arranged. The first sub-coil set includes at least one first planar coil located in a first plane. The second sub-coil set includes at least one second planar coil located in a second plane parallel to the first plane. The first planar coil and the second planar coil are connected in series. An orthogonal projection of the second planar coil on the first plane is mirror-symmetric or mirror-asymmetric to the first planar coil.

Abstract: In a method for analyzing a static analog integrated circuit layout, corresponding simulation netlists are generated from an integrated circuit layout by parasitic parameter extraction, and device-node hypergraph or graph structures reflecting a circuit topological structure are generated from the simulation netlists. Then, characteristics of RC local networks between ports of individual device groups to be matched are analyzed. An independent source current is provided at i-ports of the RC networks, AC analysis is performed on the RC local networks to acquire impedance values of j-ports at different frequencies, and then a circuit mismatch condition is determined by comparing the impedance values of the individual RC local networks.

Abstract: Structures and methods for manufacturing photovoltaic devices by forming perovskite layers and perovskite precursor layers using vapor transport deposition (VTD) are described.