Abstract: In one embodiment, there is provided an inlet for a humidification chamber for use in a medical humidification system, the inlet comprising an inlet end configured to receive gases flow from a gases source, an outlet end configured to introduce the gases flow to the inside of the humidification chamber, and at least one wall defining, at least in part, a passageway between the inlet end and the outlet end for conveying gases therebetween. The outlet end of the inlet is configured to terminate in the humidification chamber or at a wall of the humidification chamber, and the passageway is configured to guide the gases flow such that the center of the gases flow at the inlet end and at the outlet end are substantially aligned along a common axis or the outlet end defines a profile of the passageway thereat that has a width and a height, a ratio of the width to height being between about 1:20 and 1:5.

Abstract: The present invention relates to nucleic acid vaccines which encode at least a MAGED4B protein, for use in the treatment of cancer in particular. Synergistic combinations with other anti-cancer agents are described, particularly immune checkpoint inhibitors. The cancer vaccine may further comprise an immunologically active fragment to enhance the immune response, and an additional cancer antigen, such as FJX1. Particular combination therapies of interest include immunotherapies, radiotherapy, targeted therapies and chemotherapies.

Abstract: A nonlinear crystal comprising a first end face and an opposing second end face is described. The first and second end faces are separated along an optical axis of the nonlinear crystal by a length in the range of 0.25 mm and 2 mm. Although the length of the nonlinear crystal results in a reduction in the nonlinear effects induced on an optical field propagating through the crystal it also provides for reduced deviation experienced by the generated optical field when the nonlinear crystal is rotated. Therefore, when the nonlinear crystals are incorporated within an enhancement cavity their reduced length allows for the deviation of the output field to be minimised by servo control electronics arranged to adjust a single cavity mirror. This significantly reduces the complexity, and thus expensive of the servo control electronics when compared to those employed with the prior art enhancement cavities.

Abstract: A laser system comprising two phase-locked solid-state laser sources is described. The laser system can be phase-locked at a predetermined offset between the operating frequencies of the lasers. This is achieved with high precision while exhibiting both low noise and high agility around the predetermined offset frequency. A pulse generator can be employed to generate a series of optical pulses from the laser system, the number, duration and shape of which can all be selected by a user. A phase-lock feedback loop provides a means for predetermined frequency chirps and phase shifts to be introduced throughout a sequence of generated pulses. The laser system can be made highly automated. The above features render the laser system ideally suited for use within coherent control two-state quantum systems, for example atomic interferometry, gyroscopes, precision gravimeters gravity gradiometers and quantum information processing and in particular the generation and control of quantum bits.

Abstract: Disclosed is a parametric feature-based 3D CAD system that allows multiple users to simultaneously edit a parametric feature-based 3D CAD model consisting of 3D parts and assemblies of those parts (3D Model). Several CAD users, each using their own computer, phone, or tablet, can edit the same 3D Model at the same time. Editing may be separate and simultaneous—there is no need for users to worry about locking, checking out, or otherwise restricting each other's access to 3D Models. Within each user's editing interface, the model may be presented in different representations, with edits to any representation applied and displayed across all representations.

Abstract: A method and apparatus for passively synchronising the repetition rate of two or more mode-locked lasers is described. The method and apparatus involve forming a first synchronising optical field (6) by separating a portion of an output field of a first mode-locked laser (2) and thereafter redirecting this synchronising optical field to form a driving signal for a second mode-locked laser (3). Employing these techniques results in systems with timing jitter of less than 1 fs. The method is independent of the wavelength and polarisation at which the mode-locked lasers operate and so is not limited to use with any particular type of mode-locked laser. Since the technique is passive it does not require the employment of electronics, variable time delay paths or additional non-linear optical crystals. Therefore, the method and apparatus are significantly less complex than those known in the art and are not power limited by additional non-linear optical processes.

Abstract: Disclosed is a parametric feature-based 3D CAD system that allows multiple users to simultaneously edit a parametric feature-based 3D CAD model consisting of 3D parts and assemblies of those parts (3D Model). Several CAD users, each using their own computer, phone, or tablet, can edit the same 3D Model at the same time. Editing may be separate and simultaneous—there is no need for users to worry about locking, checking out, or otherwise restricting each other's access to 3D Models. As a result, users see each other's changes occur in real-time, and may also identify what aspects other users are actively modifying through visible Collaboration Cues.

Abstract: An optical frequency mixing module is described that comprises a nonlinear medium for frequency mixing the photons of one or more input optical fields to generate an output optical field; a nonlinear medium tuner for automatically phase matching the nonlinear medium to the one or more input optical fields to select the wavelength of the output optical field generated by the nonlinear medium; and a first direction correcting optic. The position of the first direction correcting optic relative to the nonlinear medium is dependent upon the selected wavelength of the output optical field and therefore ensures that the position and angle of propagation of this field remains constant and independent of its wavelength of. The optical frequency mixing modules therefore provides a means for automatically selecting the wavelength of the output field with no deviation being imparted onto the position or angle of propagation of the output field.

Abstract: A support system for determining a trajectory to be followed by an agricultural work vehicle when working a field comprises: a mapping unit configured for receiving: i) coordinates relating to the boundaries of a field to be worked; and ii) coordinates relating to the boundaries of one or more obstacles to be avoided the work vehicle; wherein the one or more obstacles being located within the field; a capacity parameter unit configured for receiving one or more capacity parameters relating to the working vehicle; a trajectory calculating unit configured for calculating an optimized trajectory to be followed by the work vehicle; wherein the optimized trajectory is being calculated on the basis of the coordinates received by the mapping unit; and one or more of the one or more capacity parameters received by the capacity parameter unit.

Abstract: A method may comprise determining, by executing a first model having first configuration parameters, a first result associated with the first model. The method may comprise determining, by executing a second model having second configuration parameters, a second result associated with the second model. The method may comprise determining, based on the first result, the second result, and equivalency criteria, that the second model is not functionally equivalent to the first model. The equivalency criteria may indicate that the second model is functionally equivalent to the first model when a difference between the second result and the first result satisfies a threshold. The method may comprise modifying a configuration parameter, of the second configuration parameters, to cause the second model to improve toward functional equivalence with the first model.

Abstract: A purging system for a laser system is described. The purging system comprising a cartridge that houses a desiccant material and which is configured for removable mounting with an enclosure of the laser system. The cartridge comprising a first mesh layer that provides a means for a fluid to flow to the desiccant material housed within the cartridge. The purging system further comprises a membrane located over the first mesh layer. The purging system therefore provides a mean for passively purging the laser system and so its operation does not require the employment of a pump. The employment of the removable cartridge also has the advantage that the downtimes of the laser system with which it is deployed are reduced during periods when it is required to dry or replace the desiccant material.

Abstract: The present disclosure relates to a support system for determining a trajectory to be followed by an agricultural work vehicle when weeding distinct areas of weed within a field of crops, the system comprising: a mapping unit configured for receiving: i) coordinates relating to the boundaries of a field to be worked; and ii) coordinates relating to the boundaries of distinct areas of weed being located within the boundary of the field of crops; a capacity parameter unit configured for receiving one or more capacity parameters relating to the working vehicle; a trajectory calculating unit configured for calculating an optimized trajectory to be followed by the work vehicle upon weeding the distinct areas of weed; wherein the optimized trajectory is being calculated on the basis of the coordinates received by the mapping unit; and one or more of the one or more capacity parameters received by the capacity parameter unit.