Abstract: An insertion device for a fluid delivery device for delivering a therapeutic fluid to a body of a patient and/or for sensing of a bodily analyte is disclosed. The insertion device includes a housing and accommodated therein at least one penetrating cartridge provided with a penetrating member and with a subcutaneously insertable element; The insertion device is provided with a displacement mechanism which upon actuation is capable of protracting the penetrating cartridge towards the said device for delivery and/or sensing, wherein said protracting results in inserting of the penetrating cartridge into subcutaneous compartment of the body via an opening provided at the said device for delivery and/or sensing and said insertion device allows evacuation of the penetrating member from the subcutaneous compartment via the said opening.

Abstract: A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient.

Abstract: The present invention provides a system and method for obtaining in vivo images. The system contains an imaging system and a transmitter for transmitting signals from a camera to a receiving system located outside a patient.

Abstract: Embodiments of the invention are directed to methods and systems associated with a disposable dispenser (100, 200) of therapeutic fluid. Preferred embodiments having a small size of less than about 75 mm in length, less than 50 mm in width and less than about 10 mm in thickness and may be releasably attached to the body (B). In one embodiments, the dispenser draws fluid from a flexible volume-conformable reservoir (4) and operates a dosing and metering pump (6, 61, 62, 63) incorporating a motor to deliver fluid through a fluid delivery tool (8, 81, 82). Disposed on the housing bottom (2B) is a peel-of-tape (22) that when removed, electrically connects a power supply (18) to power the operative components (3) of the dispenser into operation, exposes an adhesive (28) and a window (21) opened in the housing (2), and allows the fluid delivery tool (8) to extend for insertion into the skin (S).

Abstract: Embodiments of the invention are directed to systems, methods and devices for sustained medical infusion with controlled rate injection of a fluid into a body. Such a system may include a first separate reusable unit, a second separate depletable unit a third separate disposable unit having a cannula, and may include a fourth separate remote control unit. Emission of appropriate instructions from the fourth unit, when the first unit, the second unit, and the third unit are coupled together in associative operation and disposed on the skin, power is supplied to an engine for generating motion to a fluid transfer system, and when the cannula is inserted in the body, fluid is transferred from the reservoir to the body, via the tube and the cannula.

Abstract: A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient upon diffusion of the analyte into the fluid to be dispensed by the dispensing apparatus.

Abstract: A system and method for determining location and orientation of an in-vivo device, with respect to an external system in which the device is located include a frame with external magnets attached thereon. An in-vivo device is inserted into the patient's body, which is placed within the system, and the external magnets apply magnetic forces on the in-vivo device. A radio beacon transmitter is attached to the frame for transmitting a radio pulse. The in-vivo device includes an ultrasonic transmitter for transmitting an ultrasonic signal, which is triggered by the radio pulse. At least three transponders are placed on the patient's body, each transponder sending a first acoustic signal triggered by the radio pulse, and each sending a second acoustic signal triggered by the device's ultrasonic signal.

Abstract: A system and method for automatically navigating an in vivo imaging capsule in a body lumen. The system comprises an imaging capsule including an imager, optional pressure sensor for producing data of forces acting on the imaging capsule in vivo, and a transmitter to transmit image, positioning and pressure data from the capsule to an external unit. A positioning system for providing current position data of the capsule in vivo may be included in the capsule and/or external to it. External magnets may generate a magnetic field to scan a body lumen by causing a predetermined motion pattern of the imaging capsule within a region proximate to its current position, and generate a driving force to propel the imaging capsule according to a calculated target direction vector. A processor may calculate a target direction vector for propelling the imaging capsule based, on unique patterns identifiable in one or more images.

Abstract: A device, system and method for cytology acquisition which may be performed with a swallowable in vivo device, specifically with a swallowable endoscopy capsule. The swallowable capsule may comprise a rotatable drum, a brush attached onto the drum for brushing against a tissue and acquiring cytology, and a porthole through which the brush may be in contact with the tissue.

Abstract: Disclosed is an ambulatory therapeutic fluid delivery device. The device includes at least one housing connectable to a cannula, the at least one housing retaining a reservoir to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.

Abstract: Embodiments of the invention are directed to systems, methods and devices for sustained medical infusion with controlled rate injection of a fluid into a body. Such a system may include a first separate reusable unit, a second separate depletable unit a third separate disposable unit having a cannula, and may include a fourth separate remote control unit. Emission of appropriate instructions from the fourth unit, when the first unit, the second unit, and the third unit are coupled together in associative operation and disposed on the skin, power is supplied to an engine for generating motion to a fluid transfer system, and when the cannula is inserted in the body, fluid is transferred from the reservoir to the body, via the tube and the cannula.

Abstract: The present invention provides a system and method for obtaining in vivo images. The system contains an imaging system and a transmitter for transmitting signals from a camera to a receiving system located outside a patient.

Abstract: A device for cryotherapy treatment of gastrointestinal lesions includes a cooling member that may be attached to a first tube for pressurizing cryogenic fluid through the tube and into the cooling member through nozzles located at the distal end of the first tube. A second tube may be attached to the cooling member for evacuating the cryogenic fluid from within the cooling member, following the fluid's expansion once it exits the first tube. The cryotherapy device may be attached to an endoscope such that the first tube may be passed through the endoscope's working channel, while the second tube may be passed along the endoscope's circumference. The cryotherapy device may further comprise securing means attached to the first tube, for securing the first tube to the endoscope's working channel, thus preventing free rotation of the cryotherapy device within the endoscope, relative to the rotation of the endoscope.

Abstract: Systems and methods for detecting an occlusion in a fluid delivery device are disclosed. The system includes a fluid delivery tube, an occlusion detection sensor configured to be coupled to the fluid delivery tube and further configured to detect occlusion within the fluid delivery tube. The fluid delivery tube includes an occlusion detection portion. The occlusion detection sensor is further configured to detect alteration of a shape of the occlusion detection portion when at least one condition occurs within the fluid delivery tube.

Abstract: Disclosed is an ambulatory therapeutic fluid delivery device (10). The device includes at least one housing (200) connectable to a cannula (250), the at least one housing retaining a reservoir (220) to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism (150) to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.

Abstract: An in-vivo sensing system incorporating a sensing device movably disposed within a housing such that the orientation of the sensing device may be moved or changed in response to substantially small forces. The in-vivo sensing device may be ingested and may naturally traverse a lumen such as the GI tract or may be anchored at a surgical site. In a preferred embodiment, the in vivo sensing system is an imaging system (100) incorporating a sensing device such as an imaging device (112) suspended in a liquid (114) encapsulated in an covering or housing (110).

Abstract: Fluid delivery systems, methods and devices for delivering a therapeutic fluid to the body of the patient are disclosed. A fluid delivery device for delivering fluid to the body of the patient includes a housing having an upper wall, a lower wall and an opening. The device includes a well-arrangement mechanism disposed inside the housing. The well-arrangement mechanism includes a tubular member having a bore disposed between the wall openings. The device also includes a penetrating cartridge for delivery of therapeutic fluid to the body of the patient. The cartridge is configured to engage the bore following its insertion through the opening such that the therapeutic fluid can be delivered through the tubular member into the penetrating cartridge, and into the body of the patient when the penetrating cartridge engages the bore.

Abstract: A device, system and method for in-vivo sampling. An in-vivo device and method for use thereof may include a sampling chamber and a gating mechanism. The sampling chamber may store a sample of a body lumen substance, and the gate may close and open an opening of the sampling chamber.

Abstract: An endotracheal device that comprises an endotracheal tube sized and shaped for being disposed within the trachea so that at least a distal segment thereof being placed in the windpipe lumen of a patient and at least one self expending element disposed around a peripheral surface of the endotracheal tube and having a first thickness in a compressed state and a second thickness in an expanded state, the at least one self expending element switching from the compressed state to the expanded state when absorbing moisture. The first thickness is thinner than the second thickness.

Abstract: A device, system and method of in-vivo analysis. An in-vivo device may include a chromatography unit to interact in-vivo with a body lumen substance, and a sensor to sense in-vivo a property of the chromatography unit.