Abstract: Disclosed is an ambulatory therapeutic fluid delivery device (10). The device includes at least one housing (200) connectable to a cannula (250), the at least one housing retaining a reservoir (220) to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism (150) to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.

Abstract: An autonomous device that may include for example a camera, a transmitter for transmitting a signal from the camera and a storage compartment for retaining a substance in the device. A method of delivering a medicament to a patient including imaging a gastro intestinal tract with an autonomous device, identifying a target location in such tract, and releasing a medicament from the device at the target location.

Abstract: A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient upon diffusion of the analyte into the fluid to be dispensed by the dispensing apparatus.

Abstract: An in vivo imaging device with a curved reflective element and for example a concave portion of an outer shell of such device. Such curved reflective element may for example reflect onto an image sensor light rays from an object where such light rays before reflection are substantially parallel to the plane of the image sensor. An in vivo imaging device with a reflective surface situated at an angle to an image sensor of such imaging device. Such an angle may be for example a 45 degree angle so that light rays that are substantially parallel to a plain of an image sensor of an imaging device may for example be reflected by the reflective surface onto the image sensor.

Abstract: A system and method for in vivo diagnosis are provided. A composition including for example a radioactive marking agent and a pharmaceutically acceptable carrier is administered to a patient and an autonomous in vivo device, which may include for example an illumination source an image sensor and a radiation and/or light detector, is used to for example facilitate the difference between. normal and pathological cells in a body lumen.

Abstract: An insertion device (100) for a fluid delivery device (105) for delivering a therapeutic fluid to a body of a patient and/or for sensing of a bodily analyte is disclosed. The insertion device includes a housing and accommodated therein at least one penetrating cartridge (150) provided with a penetrating member and with a subcutaneously insertable element; The insertion device is provided with a displacement mechanism which upon actuation is capable of protracting the penetrating cartridge towards the said device for delivery and/or sensing, wherein said protracting results in inserting of the penetrating cartridge into subcutaneous compartment of the body via an opening provided at the said device for delivery and/or sensing and said insertion device allows evacuation of the penetrating member from the subcutaneous compartment via the said opening.

Abstract: Fluid delivery systems, methods and devices for delivering a therapeutic fluid to the body of the patient are disclosed.

Abstract: A device (4440), system and method may sense and/or analyze in-vivo pressure or stress, and may in addition sense other data such as for example, image data. An in-vivo device (4440) may include a stress or pressure sensor (4443), and possibly an additional sensor, such as an image sensor, a pH sensor, etc. In one example the stress or pressure sensor (4443) is connected to a shell (4444) of the device.

Abstract: Method and apparatus for imaging tissue by upstream illumination and downstream dual filtering of the exiting light for separation of ballistic photons rays from stray rays. Dual filtering includes spatial filtering via a pinhole and spatial filtering operated by a fast gate. A processor synchronizes flashes of illumination with the fast gate to command opening for passage of the ballistic photons rays and closure to exclude the stray rays. An image detector downstream of the fast gate collects the ballistic photons rays for processing by the processor and display on a monitor as a shadowgram. Illumination flashes have one or more wavelengths and the image detector is adapted to match the selected wavelengths of the illuminating flashes.

Abstract: A device and system including an optical head assembly and a dome, and a method for use thereof. The optical head assembly includes an illumination portion and an imaging portion and is situated behind the dome. The dome may have an optical system integrated therein.

Abstract: A reduced diameter in vivo imaging device, such as a swallowable imaging capsule. The imaging device includes a first circuit board configured for accommodating at least an image sensor, and a second circuit board, which is in electrical communication with the first circuit board and which extends substantially perpendicularly from the bottom surface of the first circuit board.

Abstract: The present invention may provide a system, method and device containing a motor. The motor may propel an in-vivo device by rotating a propeller situated for example outside of an outer shell of such device with an electromagnetic field generated by for example a plurality of electrical coils situated for example within such device.

Abstract: A substantially spherical in vivo imaging device (40) may be used for imaging body lumens in the GI tract. The imaging device (40) may include for example a ballast or weight (74) for setting a preferred orientation of the device within the body lumen. The substantially spherical shape (52) of the in vivo imaging device (40) may facilitate capturing steady streams of imaging data in large body lumens. A method of manufacture is presented.

Abstract: Device, system and method for adaptive imaging and adaptive in-vivo imaging. For example, an in-vivo imaging device may include a lens and a modifier to modify a physical property or an optical property of said lens.

Abstract: An in-vivo imaging device including a ballast that may for example orient such device in a known orientation relative to the gravitational force on such ballast. Such imaging device may, for example, assume a known orientation when it is free to move, and may capture images from such known orientation. The device may include one or more imagers, which may be oriented at different angles or points of view (e.g., forward and transverse). A method of use may include moving a patient so that the device inside the patient images different fields of view.

Abstract: A system and method may display an image stream, where an original image stream may be divided into two or more subset images streams, each subset image stream being displayed simultaneously or substantially simultaneously. The images may be displayed fused. The images may be collected from an ingestible capsule traversing the GI tract.

Abstract: Device and method for implementing a photo-spectrometer unit, PSU (20), for use with a spectrometry system (100) having optical means (12), and electronic means (13) including detection means (15, 25, 25j) and processing means (16, 26, 26k). The PSU is formed in a first manufacturing process step into a monolithic structure as a chip of substrate material (30) including integrally formed optical means, and has a first input surface (301) separated from a second receiving surface (302) by a substrate material thickness (t). Electronic means are formed onto the PSU structure in a second manufacturing process step. The substrate material is selected as a material transparent to electromagnetic radiations, and the PSU has at least one optical deflecting element (32) configured for guiding received radiations through the thickness of the substrate material, for establishing direct optical path coupling between both an element formed on one surface and an element formed on another surface of the substrate material.

Abstract: Provided are a system and method for in vivo and in situ detection of body lumen conditions. The system comprises at least one interaction chamber for containing an endo-luminal sample, the interaction chamber comprising at least one indicator; at least one light source for illuminating the interaction chamber; and at least one optical detector for detecting in vivo optical changes occurring in the interaction chamber. The reaction between the indicator and sample may result in an optical change, which is detected and possibly imaged by the optical detector.

Abstract: A system and method may display an image stream, where an original image stream may be divided into two or more subset images streams, each subset image stream being displayed simultaneously or substantially simultaneously. Post processing may be used to fuse images shown simultaneously or substantially simultaneously. The images may be collected from an ingestible capsule traversing the GI tract.

Abstract: Provided are a system and method for in vivo and in situ detection of body lumen conditions. The system comprises at least one interaction chamber for containing an endo-luminal sample, the interaction chamber comprising at least one indicator; at least one light source for illuminating the interaction chamber; and at least one optical detector for detecting in vivo optical changes occurring in the interaction chamber. The reaction between the indicator and sample may result in an optical change, which is detected and possibly imaged by the optical detector.