Patents by Inventor Gene Lee

Gene Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11935627
    Abstract: Introduced here is an approach to further refining an initial set of target locations that can serve as inputs to machine learning mechanisms. These target locations may refer to unique molecular positions in a reference human genome and/or mutations thereof that are diagnostically relevant for a given cancer type. The system can implement a refinement mechanism to account for unnecessary or problematic data, such as consecutive/overlapping patterns, non-uniform read counts, insufficient data quality, internal processing noises, and/or insufficient data counts.
    Type: Grant
    Filed: December 27, 2022
    Date of Patent: March 19, 2024
    Assignee: Mujin, Inc.
    Inventors: Cheuk Ying Tang, Edmund Wong, Gene Lee
  • Publication number: 20240082309
    Abstract: The present invention relates to a composition for bone regeneration comprising METTL7A-overexpressing stem cells, a method for preparing the same, and a cell therapy product comprising the same. According to the invention, it is possible to enhance the osteogenic differentiation ability and viability of stem cells compared to conventional stem cell therapy products for bone regeneration.
    Type: Application
    Filed: June 18, 2021
    Publication date: March 14, 2024
    Inventors: GUN IL IM, EU GENE LEE
  • Patent number: 11843645
    Abstract: Disclosed herein are system, apparatus, method and/or computer program product embodiments for providing survivable calling and conferencing. An embodiment operates by providing, by a first server, a first sub-conference to a plurality of user devices over first lines. The first sub-conference is combined with a second sub-conference to form a collective conference of the plurality of user devices. The first server accesses the conference. A second server is configured to provide the second sub-conference of the collective conference to the plurality of user devices over second lines, the first and second lines being distinct from each other. The collective conference may provide resilient and reliable sharing of information among participants and may leverage dispersed elements or diverse links simultaneously without impediments of echoes, loops, or other impacts.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: December 12, 2023
    Assignee: THE MITRE CORPORATION
    Inventors: Randall Paul Joseph Ethier, Gene Lee Harrison
  • Publication number: 20230348984
    Abstract: Systems and methods for detecting at least two genomic alleles associated with corneal dystrophy in a sample from a human subject are disclosed in which cells (e.g., epithelial) of the subject are adhered to a tip of a substrate. The tip of the substrate is agitated in a lysis solution that lyses cells adhered to the substrate. The substrate is removed from the lysis solution upon completion of this agitation. The resulting lysis solution is incubated and then genomic DNA from the lysis solution is isolated to form a gDNA solution. From this, identity of at least two nucleotides present in the human TGF?I gene is determined using at least two oligonucleotide primer pairs and the gDNA solution. These at least two nucleotides are located at respective independent positions of the TGF?I gene corresponding to respective independent single nucleotide polymorphisms (SNPs) associated with corneal dystrophy.
    Type: Application
    Filed: December 12, 2022
    Publication date: November 2, 2023
    Applicant: AVELLINO LAB USA, INC.
    Inventors: Connie Chao-Shern, Sun-Young Cho, Gene Lee
  • Publication number: 20230335279
    Abstract: Introduced here is an approach to further refining a set of locations that can serve as inputs to a machine learning algorithm. These locations may refer to unique molecular positions in a reference human genome and/or unique mutations thereof that are relevant in diagnosing cancer. A computing system can determine the diagnostic relevance of each location and then discard some of the less diagnostically relevant locations.
    Type: Application
    Filed: December 1, 2022
    Publication date: October 19, 2023
    Inventors: Cheuk Ying Tang, Victor Solovyev, Gene Lee
  • Publication number: 20230335223
    Abstract: Introduced here is an approach to further refining an initial set of target locations that can serve as inputs to machine learning mechanisms. These target locations may refer to unique molecular positions in a reference human genome and/or mutations thereof that are diagnostically relevant for a given cancer type. The system can implement a refinement mechanism to account for unnecessary or problematic data, such as consecutive/overlapping patterns, non-uniform read counts, insufficient data quality, internal processing noises, and/or insufficient data counts.
    Type: Application
    Filed: December 27, 2022
    Publication date: October 19, 2023
    Inventors: Cheuk Ying Tang, Edmund Wong, Gene Lee
  • Publication number: 20230298690
    Abstract: Introduced here is an approach to detect existence of cancer or a likely onset of cancer based on analyzing DNA data derived from unbounded samples that are not limited to specific locations of a patient’s body or specific types of cancers. One or more machine learning models may be developed using targeted patterns in the human genome. The machine learning models may be trained to analyze and detect mutation patterns characteristic of one or more cancers. The trained models may be used to analyze the unbounded samples to assess the existence cancer or the proximity to the onset of cancer based on identifying mutation patterns in the patient DNA to the patterns characteristic of the one or more cancers.
    Type: Application
    Filed: February 13, 2023
    Publication date: September 21, 2023
    Inventors: Cheuk Ying Tang, Victor Solovyev, Sidney Tobias, Gene Lee
  • Publication number: 20230282353
    Abstract: Introduced here is an approach to training a machine learning model to classify a patient amongst multiple cancer types using sets of locations that indicate where mutations typically occur for those multiple cancer types. Upon being applied to genetic information associated with a patient whose health state is unknown, the machine learning model can produce, as input, values that indicate the likelihood of the patient having each of the multiple cancer types. Also introduced here is an approach in which diagnoses are predicted in an improved manner through the application of different models in “tiers” or “stages.” The approach may involve applying a set of multiple models to the genetic information of an individual in order to ascertain the health of the individual, and each of the multiple models can be used to indicate whether the next model in the set should be applied.
    Type: Application
    Filed: December 29, 2022
    Publication date: September 7, 2023
    Inventors: Cheuk Ying Tang, Victor Solovyev, Sidney Tobias, Gene Lee
  • Publication number: 20230274794
    Abstract: Introduced here is an approach to training a machine learning model to classify a patient amongst multiple cancer types using sets of locations that indicate where mutations typically occur for those multiple cancer types. Upon being applied to genetic information associated with a patient whose health state is unknown, the machine learning model can produce, as input, values that indicate the likelihood of the patient having each of the multiple cancer types. Also introduced here is an approach in which diagnoses are predicted in an improved manner through the application of different models in “tiers” or “stages.” The approach may involve applying a set of multiple models to the genetic information of an individual in order to ascertain the health of the individual, and each of the multiple models can be used to indicate whether the next model in the set should be applied.
    Type: Application
    Filed: December 29, 2022
    Publication date: August 31, 2023
    Inventors: Cheuk Ying Tang, Victor Solovyev, Gene Lee
  • Patent number: 11715342
    Abstract: A camera captures a display of a gaming device and determines information that appears on the display. The camera is mounted on a video gaming device, and the camera continuously or at various intervals captures images of the screen of the video gaming device. Those images are analyzed to determine information displayed on the video gaming device, such as game speed (e.g., time between handle pulls, total time of play, handle pulls during a session, etc.), bet amounts, bet lines, credits, etc. This information may be determined in various ways, such as by using image processing of images captured by the camera. Machine learning algorithms may also be used to infer key information displayed on the screen of the video gaming device to capture and/or analyze. A housing of the camera may also have a secondary display oriented in a similar direction as the screen of the video gaming device.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 1, 2023
    Inventors: Thompson Nguyen, Jayendu Sharma, Joshua Frank, Gene Lee
  • Publication number: 20230234702
    Abstract: Aircraft and propeller assemblies may include a propeller adapter with a plurality of propeller blades coupled to the propeller adapter in a common plane. At least one propeller blade of the plurality of propeller blades may be pivotably coupled to the propeller adapter to pivot within the common plane. A spring may be coupled between a portion of the propeller adapter and a portion of the at least one propeller blade pivotably coupled to the propeller adapter. Other aspects, embodiments, and features are also included.
    Type: Application
    Filed: January 21, 2022
    Publication date: July 27, 2023
    Inventor: Gene Lee Watterson, III
  • Patent number: 11658043
    Abstract: A method of patterning a substrate is provided. The method includes modifying a surface of a metal-containing layer formed over a substrate positioned in a processing region of a processing chamber by exposing the surface of the metal-containing layer to plasma effluents of a chlorine-containing gas precursor and an oxygen-containing gas precursor to form a modified surface of the metal-containing layer. The method further includes directing plasma effluents of an inert gas precursor towards the modified surface of the metal-containing layer. The plasma effluents of the inert gas precursor are directed by applying a bias voltage to a substrate support holding the substrate. The method further includes anisotropically etching the modified surface of the metal-containing layer with the plasma effluents of the inert gas precursor to form a first recess having a first sidewall in the metal-containing layer.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: May 23, 2023
    Assignee: APPLIED MATERIALS, INC.
    Inventors: Jonathan Shaw, Priyadarshi Panda, Nancy Fung, Yongchang Dong, Somaye Rasouli, Gene Lee
  • Publication number: 20230093450
    Abstract: The present disclosure provides forming nanostructures utilizing multiple patterning process with good profile control and feature transfer integrity. In one embodiment, a method for forming features on a substrate includes forming a first mandrel layer on a material layer disposed on a substrate. A first spacer layer is conformally formed on sidewalls of the first mandrel layer, wherein the first spacer layer comprises a doped silicon material. The first mandrel layer is selectively removed while keeping the first spacer layer. A second spacer layer is conformally formed on sidewalls of the first spacer layer and selectively removing the first spacer layer while keeping the second spacer layer.
    Type: Application
    Filed: November 30, 2022
    Publication date: March 23, 2023
    Inventors: Tzu-shun YANG, Rui CHENG, Karthik JANAKIRAMAN, Zubin HUANG, Diwakar KEDLAYA, Meenakshi GUPTA, Srinivas GUGGILLA, Yung-chen LIN, Hidetaka OSHIO, Chao LI, Gene LEE
  • Publication number: 20230083577
    Abstract: Embodiments described herein generally relate to electronic devices and electronic device manufacturing. More particularly, some embodiments of the present disclosure provide methods of manufacturing memory devices, for example, dynamic random-access memory cells with buried word-lines. In an embodiment, a method of manufacturing an electronic device is provided. The method includes recessing a metal layer to a first predetermined depth to form a recessed metal layer. The metal layer at least partially fills each feature of a plurality of features formed on a substrate and each feature has a feature depth. The method further includes exposing the recessed metal layer to a carbon-containing plasma to form a metal-carbide layer on the recessed metal layer. The method further includes recessing the recessed metal layer to a second predetermined depth by etching the metal-carbide layer and the recessed metal layer.
    Type: Application
    Filed: August 19, 2022
    Publication date: March 16, 2023
    Inventors: Wangkeun CHO, Gene LEE
  • Patent number: 11527408
    Abstract: The present disclosure provides forming nanostructures utilizing multiple patterning process with good profile control and feature transfer integrity. In one embodiment, a method for forming features on a substrate includes forming a first mandrel layer on a material layer disposed on a substrate. A first spacer layer is conformally formed on sidewalls of the first mandrel layer, wherein the first spacer layer comprises a doped silicon material. The first mandrel layer is selectively removed while keeping the first spacer layer. A second spacer layer is conformally formed on sidewalls of the first spacer layer and selectively removing the first spacer layer while keeping the second spacer layer.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: December 13, 2022
    Assignee: Applied Materials, Inc.
    Inventors: Tzu-shun Yang, Rui Cheng, Karthik Janakiraman, Zubin Huang, Diwakar Kedlaya, Meenakshi Gupta, Srinivas Guggilla, Yung-chen Lin, Hidetaka Oshio, Chao Li, Gene Lee
  • Patent number: 11525160
    Abstract: Systems and methods for detecting at least two genomic alleles associated with corneal dystrophy in a sample from a human subject are disclosed in which cells (e.g., epithelial) of the subject are adhered to a tip of a substrate. The tip of the substrate is agitated in a lysis solution that lyses cells adhered to the substrate. The substrate is removed from the lysis solution upon completion of this agitation. The resulting lysis solution is incubated and then genomic DNA from the lysis solution is isolated to form a gDNA solution. From this, identity of at least two nucleotides present in the human TGF?I gene is determined using at least two oligonucleotide primer pairs and the gDNA solution. These at least two nucleotides are located at respective independent positions of the TGF?I gene corresponding to respective independent single nucleotide polymorphisms (SNPs) associated with corneal dystrophy.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: December 13, 2022
    Assignee: Avellino Lab USA, Inc.
    Inventors: Connie Chao-Shern, Sun-Young Cho, Gene Lee
  • Publication number: 20220359201
    Abstract: A method for forming a metal containing feature includes performing a deposition process, the deposition process comprising conformally depositing an over layer on top surfaces of a patterned mandrel layer and over a spacer layer on sidewalls of the patterned mandrel layer, and performing an etch process, the etch process comprising removing the over layer from the top surfaces of the patterned mandrel layer and shoulder portions of the spacer layer, and removing the shoulder portions of the spacer layer, using a fluorine containing etching gas.
    Type: Application
    Filed: April 4, 2022
    Publication date: November 10, 2022
    Inventors: Chao LI, Gene LEE
  • Publication number: 20220285167
    Abstract: A method for selective barrier metal etching includes performing a hydrogen implantation process, in an inductively coupled plasma (ICP) etch chamber, to chemically reduce an oxidized portion of a barrier metal layer formed within a feature in a metal layer on the barrier metal layer, and performing an etch process, in the ICP etch chamber, to remove the hydrogen implanted portion of the barrier metal layer.
    Type: Application
    Filed: February 3, 2022
    Publication date: September 8, 2022
    Inventors: Jonathan SHAW, Gene LEE
  • Publication number: 20220205044
    Abstract: The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.
    Type: Application
    Filed: January 26, 2022
    Publication date: June 30, 2022
    Applicant: Avellino Co., Ltd.
    Inventors: Gene Lee, Jung Kuk Yun
  • Publication number: 20220189771
    Abstract: A structure includes an underlayer formed on a substrate, a mandrel layer formed on the underlayer, and a spacer layer formed on the mandrel layer. The underlayer includes a first material, and the spacer layer includes a second material. The first material is resistant to etching gases used in a first etch process to remove portions of the spacer layer and a second etch process to remove the mandrel layer.
    Type: Application
    Filed: January 25, 2021
    Publication date: June 16, 2022
    Inventors: Gene LEE, Gabriela ALVA