Abstract: A hose end coupling comprising a unitary one-piece stem having an exterior barb end portion and an exterior ferrule interface portion, with a unitary one-piece radially crushable ferrule disposed over the stein, with a crushable socket portion disposed about the barb end portion, a deformable attachment portion disposed about the ferrule interface portion, and a torque communication portion defined between the socket portion and the attachment portion. The socket portion may retain a “C” shaped insert, one or more coiled inserts, or a plurality of stacked inserts, for gripping a hose end and the socket portion might define a lip, with a seal disposed in the socket portion between the insert(s) and the lip. Some embodiments of a “C” shaped insert define inner-circumferential teeth and corresponding outer-circumferential depression indentions.

Abstract: A multi-port connector includes a plate employing a plurality of coupling retention mechanisms used to hold a plurality of fluid connectors in alignment for deployment with a respective plurality of fluid ports defined in a structure. The couplings may be loosely retained in the plate to facilitate alignment with the ports and ultimately insertion of the connectors into the ports. Each of the coupling retention mechanisms might be an opening through the plate with engagement mechanism defined within, or in conjunction with, the opening. In accordance with various embodiments of the present invention a (central) fastener may pass through the plate to selectively draw and secure the plurality of fluid connectors into engagement with the respective plurality of ports.

Abstract: Tools and techniques are described for dimension-based financial reporting using multiple combinations of dimensions. These tools may provide methods that include receiving requests, submitted on behalf of users of dimension-based financial reporting systems. These methods may create reports from the financial reporting systems. In some cases, these requests from the users may reference incomplete account structures, and may also specify customized hierarchies for the reports. In such cases, the methods may determine that these requests reference incomplete account structures, and may transform the incomplete account structures to create fully-qualified requests. In addition, these methods may include identifying dimensions, as maintained by the financial reporting systems, that are responsive to the requests, and may combine these dimensions into responses to the requests.

Abstract: A lab-on-a-chip (LOC) device having a supporting substrate, a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section having at least one heater, and, CMOS circuitry between the supporting substrate and the incubation section, wherein, the CMOS circuitry is connected to the at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period.

Abstract: A hose end coupling comprising a unitary one-piece stem having an exterior barb end portion and an exterior ferrule interface portion, with a unitary one-piece radially crushable ferrule disposed over the stem, with a crushable socket portion disposed about the barb end portion, a deformable attachment portion disposed about the ferrule interface portion, and a torque communication portion defined between the socket portion and the attachment portion. The socket portion may retain a “C” shaped insert, one or more coiled inserts, or a plurality of stacked inserts, for gripping a hose end and the socket portion might define a lip, with a seal disposed in the socket portion between the insert(s) and the lip. Some embodiments of a “C” shaped insert define inner-circumferential teeth and corresponding outer-circumferential depression indentions.

Abstract: 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

Abstract: A protective garment is provided and includes a jacket having various releasably mounted protective components. The jacket includes a protective collar of ballistic resistant fabric for protecting the neck of a wearer and has front and rear portions which are releasably connected together at opposed side portions of the collar so that the front and rear portions can fold down when not in use. A protective plate is releasably fastened to the front of the jacket and the fastening mechanism allows the plate to be held in a number of different vertical positions. The jacket also includes a rear pocket for housing a rear protective plate. The sleeves of the jacket include a sleeve extension which is slideably mounted to the main sleeve to vary its effective length.

Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.

Abstract: Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses.

Abstract: Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.

Abstract: 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

Abstract: Diagnostic and response systems and methods for a fluid power system acquire data from pressure and temperature sensors disposed in the fluid power system, analyze the data in a failure algorithm to build a history of cumulative damage to hoses in the fluid power system, communicates an indication of potential imminent hose failure to a central location when a level of the cumulative damage indicates imminent failure of a hose, analyze the information at the central location to determine an appropriate response, and transmit information about the fluid power system, including location, and identification of the hose about to fail to a response unit. The response unit responds to the location and replaces the component prior to failure, or the communication might include information that the hose has failed, such that the response unit replaces the failed hose to return the fluid power system to normal operation.

Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.

Abstract: 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

Abstract: A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplifi

Abstract: A microfluidic device for amplifying DNA and RNA, the microfluidic device having an inlet for receiving a sample containing genetic material including DNA and RNA, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section.

Abstract: A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating small constituents from larger constituents in the sample, a plurality of reagent reservoirs, a nucleic acid amplification section downstream of the dialysis section for amplifying nucleic acid sequences in the sample, wherein, the dialysis section and the nucleic acid amplification section are both supported on the supporting substrate.

Abstract: A microfluidic device for amplifying and detecting target nucleic acid sequences in a sample, the microfluidic device having a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and, a hybridization section that has an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and a plurality of electrodes for receiving an electrical pulse such that the probe-target hybrids emit a photon of light.

Abstract: A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a first portion of the sample flow from the lysis section, and, a second nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a second portion of the sample flow from the lysis section, wherein, the dialysis section, the lysis section, the first nucleic acid ampl

Abstract: A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes are arranged in pairs, one of the electrodes in each electrode pair being a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, the working electrode being positioned such that the probes are between the photosensor and the working electrode.