Patents by Inventor Gerd Ascher

Gerd Ascher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120046276
    Abstract: A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 23, 2012
    Applicant: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Rosemarie Mang
  • Patent number: 8088823
    Abstract: A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: January 3, 2012
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Rosemarie Mang
  • Patent number: 7816389
    Abstract: 14-O—[(((C1-6)Alkoxy-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O—[(((C1-6)Mono- or dialkylamino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C1-6)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Formyl-(C0-5)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Guanidino-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Ureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Thioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Isothioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins and their use as pharmaceuticals.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: October 19, 2010
    Assignee: Nabriva Therapeutics Forschungs GmbH
    Inventors: Klaus Thirring, Gerd Ascher, Susanne Paukner, Werner Heilmayer, Rodger Novak
  • Patent number: 7790767
    Abstract: The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3? are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: September 7, 2010
    Assignee: Nabriva Therapeutics Forschungs GmbH
    Inventors: Rosemarie Mang, Gerd Ascher, Mathias Ferencic, Werner Heilmayer, Rodger Novak
  • Patent number: 7790749
    Abstract: A method of preventing or treating diseases mediated by Helicobacter pylori, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: September 7, 2010
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Johannes Hildebrandt
  • Publication number: 20100160266
    Abstract: A pleuromutilin in the form of a salt with salicylic acid, azelaic acid, sebacic acid or 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid.
    Type: Application
    Filed: June 14, 2006
    Publication date: June 24, 2010
    Applicant: NABRIVA THERAPEUTICS FORSCHUNGS GMBH
    Inventor: Gerd Ascher
  • Publication number: 20090306203
    Abstract: The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3? are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
    Type: Application
    Filed: June 26, 2006
    Publication date: December 10, 2009
    Applicant: Nabriva Therapeutics Forschungs GmbH
    Inventors: Rosemarie Mang, Gerd Ascher, Mathias Ferencic, Werner Heilmayer, Rodger Novak
  • Publication number: 20090209584
    Abstract: A compound of formula (I) wherein R and R2 and the attached nitrogen atom form pyrrolidinyl or piperidinyl. R1 is a group of formula (II). R3 and R?3 are hydrogen, deuterium or halogen. R4, R5 and R10 are independently of each other hydrogen or alkyl. R6, R7 and R8 are hydrogen or deuterium. R9 is amino, alkyl, aryl, heterocyclyl or mercapto. If X is oxygen, R9 is additionally hydrogen; R?10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0, 1 or 2, with the proviso that, when R and R2 and the attached nitrogen atom form piperidinyl, m is O, Y is S and Y is attached in position 3 of the piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S)-configuration which is useful as antimicrobial, antibacterial.
    Type: Application
    Filed: April 7, 2009
    Publication date: August 20, 2009
    Applicant: Nabriva Therapeutics Forschungs AG
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 7569587
    Abstract: A compound of formula (I) wherein R and R2 and the attached nitrogen atom form pyrrolidinyl or piperidinyl. R1 is a group of formula (II). R3 and R?3 are hydrogen, deuterium or halogen. R4, R5 and R10 are independently of each other hydrogen or alkyl. R6, R7 and R8 are hydrogen or deuterium. R9 is amino, alkyl, aryl, heterocyclyl or mercapto. If X is oxygen, R9 is additionally hydrogen; R?10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0,1 or 2, with the proviso that, when R and R2 and the attached nitrogen atom form piperidinyl, m is O, Y is S and Y is attached in position 3 of the piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S)-configuration which is useful as antimicrobial, antibacterial.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: August 4, 2009
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 7534814
    Abstract: A compound of formula wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 19, 2009
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 7485632
    Abstract: A compound of formula wherein the substituents have various meanings, useful as a pharmaceutical.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: February 3, 2009
    Assignee: Nabriva Therapeutics Forschungs GmbH
    Inventors: Gerd Ascher, Werner Heilmayer, Michael Schranz, Josef Wieser
  • Publication number: 20080287442
    Abstract: 14-O—[(((C1-6)Alkoxy-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O—[(((C1-6)Mono- or dialkylamino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C1-8)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Formyl-(C0-5)-alkyl)-phenylsulfanyl)-acetyl]-mutilins 14-O-[((Guanidino-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Ureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Thioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Isothioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins and their use as pharmaceuticals.
    Type: Application
    Filed: January 11, 2007
    Publication date: November 20, 2008
    Applicant: Nabriva Therapeutics Forschungs GmbH
    Inventors: Klaus Thirring, Gerd Ascher, Susanne Paukner, Werner Heilmayer, Rodger Novak
  • Publication number: 20080009470
    Abstract: A compound of formula wherein R has various meanings and its use as a pharmaceutical.
    Type: Application
    Filed: November 4, 2004
    Publication date: January 10, 2008
    Inventors: Gerd Ascher, Mathias Ferencic
  • Patent number: 7317101
    Abstract: A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: January 8, 2008
    Assignee: Sandoz GmbH
    Inventors: Gerd Ascher, Johannes Ludescher
  • Publication number: 20070270404
    Abstract: A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
    Type: Application
    Filed: June 13, 2007
    Publication date: November 22, 2007
    Applicant: Nabriva Therapeutics Forschungs GmbH
    Inventors: Gerd Ascher, Friedrich Stauffer, Heinz Berner, Rosemarie Mang
  • Publication number: 20070135483
    Abstract: A compound of formula (I) wherein R and R2 together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R1 is a group of formula (II) R3 and R?3 are hydrogen, deuterium or halogen, R4, R5 and R10 are independently of each other hydrogen or alkyl, R6, R7 and R8 are hydrogen or deuterium; R9 is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R9 is additionally hydrogen; R10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0,1 or 2; with the proviso that, when R and R2 together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-conflguration, preferably in the (S)-configuration which is e.g. useful as antimicrobial, antibacterial.
    Type: Application
    Filed: January 12, 2007
    Publication date: June 14, 2007
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 7169804
    Abstract: A compound of formula (I) wherein R and R2 together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R1 is a group of formula (II) R3 and R?3 are hydrogen, deuterium or halogen, R4, R5 and R10 are independently of each other hydrogen or alkyl, R6, R7 and R8 are hydrogen or deuterium; R9 is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R9 is additionally hydrogen; R?10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0, 1 or 2; with the proviso that, when R and R2 together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S) -configuration which is e.g. useful as antimicrobial, antibacterial.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: January 30, 2007
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Publication number: 20060223789
    Abstract: A compound of formula wherein W, V, R1, R5, R2, R3 and R4 have various meanings, a process for their production and their use as a pharmaceutical.
    Type: Application
    Filed: December 5, 2005
    Publication date: October 5, 2006
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Jonannes Ludescher, Johannes Hilldebrandt
  • Publication number: 20060122164
    Abstract: A pharmaceutically active compound having a carboxylic acid group —COOH as a part of its chemical structure which —COOH group is in the form of a carboxylic acid ester.
    Type: Application
    Filed: January 27, 2004
    Publication date: June 8, 2006
    Inventors: Gerd Ascher, Klaus Thirring
  • Publication number: 20050234233
    Abstract: A compound of formula wherein the substituents have various meanings, useful as a pharmaceutical.
    Type: Application
    Filed: July 14, 2003
    Publication date: October 20, 2005
    Inventors: Gerd Ascher, Werner Heilmayer, Michael Schranz, Josef Wieser