Patents by Inventor Gerd Ascher

Gerd Ascher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cephalosporins
    Publication number: 20050234233
    Abstract: A compound of formula wherein the substituents have various meanings, useful as a pharmaceutical.
    Type: Application
    Filed: July 14, 2003
    Publication date: October 20, 2005
    Inventors: Gerd Ascher, Werner Heilmayer, Michael Schranz, Josef Wieser
  • Tuberculosis treatment
    Publication number: 20050215637
    Abstract: A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
    Type: Application
    Filed: March 27, 2003
    Publication date: September 29, 2005
    Inventors: Gerd Ascher, Friedrich Stauffer, Heinz Berner, Rosemarie Mang
  • Use of pleuromutilins for the treatment of disorders caused by helicobacter pylori
    Publication number: 20050131023
    Abstract: A method of preventing or treating diseases mediated by Helicobacter pylori, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.
    Type: Application
    Filed: April 22, 2003
    Publication date: June 16, 2005
    Inventors: Gerd Ascher, Johannes Hildebrandt
  • Mutilin derivatives and their use as antibacterials
    Publication number: 20040235910
    Abstract: A compound of formula 1
    Type: Application
    Filed: June 14, 2004
    Publication date: November 25, 2004
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Mutilin derivatives and their use as antibacterials
    Patent number: 6784193
    Abstract: A compound of formula (I) wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: August 31, 2004
    Assignee: Sandoz GmbH
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
    Publication number: 20040132709
    Abstract: A compound of formula 1
    Type: Application
    Filed: November 12, 2003
    Publication date: July 8, 2004
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Pleuromutilin derivatives having antibacterial activity
    Patent number: 6753445
    Abstract: A compound selected from 14—O—[(cycloalkyl-sulfanyl)acetyl]mutilins; 14—O—[(cycloalkyl-alkyl-sulfanyl)acetyl] mutilins; 14—O—[(cycloalkoxy)acetyl] mutilins; and 14—O—[(cycloalkyl-alkoxy)acetyl] mutilins and its use as a pharmaceutical.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: June 22, 2004
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Heinz Berner
  • Antibacterial Mutilins
    Publication number: 20040102482
    Abstract: A compound of formula (I) wherein R and R2 together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R1 is a group of formula (II) R3 and R′3 are hydrogen, deuterium or halogen, R4, R5 and R10 are independently of each other hydrogen or alkyl, R6, R7 and R8 are hydrogen or deuterium; R9 is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R9 is additionally hydrogen; R′10 is alkyl, X is sulphur, oxygen, NR10, or N+(R′10)2; Y is sulphur or oxygen, and m is 0, 1 or 2; with the proviso that, when R and R2 together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S) -configuration which is e.g. useful as antimicrobial, antibacterial.
    Type: Application
    Filed: March 10, 2003
    Publication date: May 27, 2004
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
    Patent number: 6693095
    Abstract: A compound of formula wherein W, V, R1, R5, R2, R3 and R4 have various meanings, a process for their production and their use as a pharmaceutical.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: February 17, 2004
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Antibacterial cephalosporins
    Publication number: 20030191105
    Abstract: A compound of formula 1
    Type: Application
    Filed: December 3, 2002
    Publication date: October 9, 2003
    Inventors: Gerd Ascher, Johannes Ludescher
  • Pleuromutilin derivatives having antibacterial activity
    Publication number: 20030162831
    Abstract: A compound selected from 14—O—[(cycloalkyl-sulfanyl)acetyl]mutilins; 14—O—[(cycloalkyl-alkyl-sulfanyl)acetyl] mutilins; 14—O—[(cycloalkoxy)acetyl] mutilins; and 14—O—[(cycloalkyl-alkoxy)acetyl] mutilins and its use as a pharmaceutical.
    Type: Application
    Filed: January 9, 2003
    Publication date: August 28, 2003
    Inventors: Gerd Ascher, Heinz Berner
  • Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
    Publication number: 20030114665
    Abstract: A compound of formula 1
    Type: Application
    Filed: September 23, 2002
    Publication date: June 19, 2003
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Antibacterial cephalosporins
    Patent number: 6531465
    Abstract: A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: March 11, 2003
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher
  • Cephalosporines having cyclic aminoguanidine substituents as antibiotics
    Patent number: 6440957
    Abstract: A compound useful as an anti-bacterial agent, having the formula wherein R2 together with the nitrogen atom to which it is attached forms a cyclic aminoguanidine group or derivative thereof as defined
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: August 27, 2002
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Werner Heilmayer, Johannes Ludescher, Johannes Hildebrandt, Michael Schranz, Josef Wieser
  • Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
    Publication number: 20020115852
    Abstract: A compound of formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: August 22, 2002
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
    Publication number: 20020091252
    Abstract: A compound of formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: July 11, 2002
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Process for the production of 3-vinyl cephalosporins
    Patent number: 6414140
    Abstract: A process for the production of a 3-vinylcephalosporin compound of formula I wherein R1 and R2 denote hydrogen or an organic group by a Wittig reaction reacting first a compound of formula II with a compound of formula P(R4)3 or P(OR4)3 to produce a compound of formula III and secondly reacting the compound of formula III with a weak base of formula or of formula R10—COO−W+ wherein R5 is hydrogen, alkly or aryl and R6 and R7 are each an activated group of formula —COOR8, —CN, —SO2R8, —COR8 or —CON(R8)2; or R5 and R8 are each aryl and R7 is an activated group of formula —COOR8, —CN, —SO2R8, —COR8 or —CON(R8)2, W+ is an alkali metal cation and R10 is alkyl or aryl to produce a compound of formula IV and finally reacting a compound of formula IV with a compound of formula V to produce a compound of formula I.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: July 2, 2002
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Josef Wieser, Gerd Ascher, Johannes Ludescher, Herbert Sturm
  • Process for the production of 3-vinyl cephalosporins
    Publication number: 20010007029
    Abstract: A process for the production of 3-vinylcephalosporin compounds of formula 1
    Type: Application
    Filed: February 23, 2001
    Publication date: July 5, 2001
    Inventors: Josef Wieser, Gerd Ascher, Johannes Ludescher, Herbert Sturm
  • Intermediates and process for the production of 3-vinyl cephalosporins
    Patent number: 6248881
    Abstract: A process for the production of a 3-vinylcephalosporin compound of formula I wherein R1 and R2 may be the same or different and denote hydrogen or an organic radical, which comprises subjecting a 3-iodomethyl-cephalosporin to a Wittig reaction in the presence of a weak base.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: June 19, 2001
    Assignee: Biochemie GmbH
    Inventors: Josef Wieser, Gerd Ascher, Johannes Ludescher, Herbert Sturm
  • Cephalosporin compounds
    Patent number: 6093813
    Abstract: Cephalosporin derivatives of formula II ##STR1## wherein R.sup.a denotes hydrogen or a silyl group; R.sup.b denotes a group of formula --OR.sup.e, wherein R.sup.e denotes hydrogen or alkyl; and R.sup.c and R.sup.d together denote a bond; in free form or in salt form.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: July 25, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser