Abstract: Motion generating devices for imparting motion to interventional devices to aid in the use of such interventional devices, and methods of making and using the same. An exemplary motion generating device of the present disclosure comprises at least one motion source, such as a motor, voice coil actuator, or the like, and a mating surface configured to engage an interventional device, wherein the motion generating device can impart multimodal vibrational and/or rotational movement, both independently and/or simultaneously, to the interventional device thereby aiding in the advancement of the interventional device through the vasculature of a patient.

Abstract: Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify the locations of intraluminal structures and medical devices during non-surgical medical techniques, by determining the conductance and/or cross-sectional area at a plurality of locations within the body lumen.

Abstract: Devices, systems, and methods for use with suction within a mammalian body. In an exemplary embodiment of a device of the present disclosure, the device comprises one or more of the following: an inner tube, an outer tube, and a foldable portion, whereby movement of the two tubes relative to one another causes the foldable portion to form a suction cup, and conversely causes a suction cup to form a foldable portion, depending on the direction of relative movement.

Abstract: Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify and locate lesions and/or anatomical structures within a lumen and accurately place leads and/or devices within a lumen, through determining the intralumen conductance and/or cross-sectional area at a plurality of locations within the body lumen.

Abstract: Thrombectomy systems and devices and methods of using the same. In an exemplary embodiment of a thrombectomy system of the present disclosure, the thrombectomy system comprises a thrombectomy sheath, comprising a circumferential outer wall reinforced with a reinforcement, configured as an elongated tube having a lumen therethrough; and a sonovisible element positioned at or near a distal end of the circumferential outer wall; wherein the thrombectomy sheath is sized and shaped to be at least partially positioned within a vein proximal to a thrombus or other item within the vein and further configured to expand to contact the vein to secure the thrombectomy sheath within the vein; and wherein the lumen is sized and shaped to receive a device selected from the group consisting of a balloon catheter and a snare having a loop.

Abstract: A minimally invasive system for monitoring and treating high intracranial pressure levels resulting from traumatic brain injury comprises an intravenous access device, an elongate member, a console, and an aspiration and injection catheter. The system is capable of monitoring pressure levels and relocating fluid from the brain to another part of the patient's body to sustain overall constant fluid volume. The method of using the minimally invasive system is also described.

Abstract: Transradial access devices, systems, and methods. An exemplary device of the present disclosure for providing access to a vessel or other luminal organ and to prevent overperforation of the same including a needle having a needle tip and at least one current element positioned thereon or embedded therein at or near the needle tip, a sheath positioned around at least part of the needle, and a protractor in communication with the needle, whereby engagement of the protractor causes the needle tip to protract from the sheath through the aperture, and whereby release of the protractor causes the needle tip to retract through the aperture into the sheath. Activation of the at least one current element can facilitate vasodilation of the vessel or other luminal organ.

Abstract: A novel glue for embolization of lymphatic leakage. An optimized lymphatic embolization agent (LEA) as described herein comprises a NAM hydrogel and tantalum at a mixture of at or about 1:3 tantalum to NAM hydrogel, wherein said LEA is radiopaque.

Abstract: Devices, systems, and methods for use with suction within a mammalian body. In an exemplary embodiment of a device of the present disclosure, the device comprises one or more of the following: an inner tube, an outer tube, and a foldable portion, whereby movement of the two tubes relative to one another causes the foldable portion to form a suction cup, and conversely causes a suction cup to form a foldable portion, depending on the direction of relative movement.

Abstract: Impedance devices with integrated circuit modules and method of using the same to obtain luminal organ information. In one embodiment, a device comprises an elongated body for at least partial insertion into a mammalian luminal organ and having a first conductor extending therethrough, a proximal electrical unit connected to the elongated body to deliver power along the first conductor, and a sensor substrate located at or near a distal end of the elongated body and comprising a circuit module operable and/or configured to direct the sizing portion to obtain sizing data and the pressure sensor to obtain pressure data, and facilitate transmission of the sizing data and/or the pressure data to the proximal electrical unit.

Abstract: Methods to generate elongated wires having a metallic substrate thereon and devices comprising the same. In a method of generating a device, the method comprises the steps of applying a first nonconductive coating upon an elongated core body of the device; applying a first conductive coating upon the first nonconductive coating; applying a photoresist coating upon the first conductive coating; directing a laser/light from a laser/light source upon portions of the photoresist coating to cause said portions of the photoresist coating to harden; applying a first chemical to the photoresist coating to remove the photoresist coating that was not hardened by the laser/light; and applying a second chemical to the hardened photoresist coating to expose portions of the first conductive coating previously positioned below the hardened photoresist coating.

Abstract: A minimally invasive system for monitoring and treating high intracranial pressure levels resulting from traumatic brain injury comprises an intravenous access device, an elongate member, a console, and an aspiration and injection catheter. The system is capable of monitoring pressure levels and relocating fluid from the brain to another part of the patient's body to sustain overall constant fluid volume. The method of using the minimally invasive system is also described.

Abstract: Single injection methods for obtaining conductance measurements within luminal organs using impedance devices. In at least one method embodiment, the method is performed by introducing at least part of an impedance device into a mammalian luminal organ, the impedance device comprising an elongated body and a detector positioned along the elongated body, obtaining conductance measurements indicative of a fluid native to the mammalian luminal organ and indicative of a fluid injection while the detector is present within and outside of the lumen of the outer sheath, and calculating a size parameter of the mammalian luminal organ based in part upon some of the obtained conductance measurements.

Abstract: Systems and methods for selective auto-retroperfusion along with regional mild hypothermia.

Abstract: Systems and methods for navigation and positioning a central venous catheter within a patient. The system may include a first pole and a second pole designed to generate an electric field sufficient to obtain a plurality of field measurements. The system may include a stylet inserted into a medical device. The stylet may include a magnetic assembly configured to produce a magnetic field positioned along a distal portion of the stylet, and a stylet electrode positioned distal of the magnetic assembly. The stylet electrode may be designed to function as both an interior excitation electrode and an interior detection electrode. Advancement of the medical device in the patient may include using a conductance curve generated from the plurality of field measurements to identify an obstruction or malposition in the patient.

Abstract: Devices, systems, and methods for accessing the internal and external tissues of the heart are disclosed. At least some of the embodiments disclosed herein provide access to the external surface of the heart through the pericardial space for localized delivery of substances to the heart tissue. In addition, various disclosed embodiments provide access to the internal surface of the heart for aspiration and delivery of substances to a targeted region without disturbing or interfering with nearby structures or surfaces.

Abstract: Expandable endograft devices, systems, and methods of using the same to partially or fully occlude a luminal organ. An endograft device described herein may include a stent portion and a wall portion, wherein the wall portion is configured to receive a substance therein.

Abstract: Devices, systems, and methods for identifying a target location for implantation of a pacing lead to treat heart failure. The present disclosure includes disclosure of a method, comprising the steps of inserting at least part of a suction catheter into a blood vessel of a patient and advancing the at least part of the suction catheter to a heart, suctionally engaging a tissue of the heart using the suction catheter, positioning a pacing lead from a lumen of the suction catheter into the tissue of the heart at a first location, and operating the pacing lead in attempt to sense and confirm the presence of an indicator of the heart.

Abstract: Devices, systems, and methods to treat hypertension. In at least one embodiment of a method of the present disclosure, the method comprises the step of obtaining data indicative of a renal artery of a patient with hypertension; and if the data indicates that the renal artery is stiff, relatively stiff, noncompliant, or relatively noncompliant, the method further comprises the step of performing a renal ablation procedure on the renal artery to treat the hypertension.

Abstract: Atrial appendage occlusion devices and methods of using the same that employ the application of light having a desired wavelength range. The devices of the present disclosure comprise a telescoping catheter assembly coupled with an adhesive delivery device and a suction source, and comprise at least one optical fiber disposed therein. The catheter assembly is configured to isolate an atrial appendage cavity, deliver suction and adhesive thereto, and, using the optical fiber(s), cure the adhesive present within the cavity all without withdrawing any components of the catheter assembly from the body. Methods for using such device in the treatment of atrial appendage occlusion are also provided.