Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue applies a heat source to kill cells without protein denaturation. The hyperthermia treatment may further comprise platelet-derived treatment. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. The temperature to which the target site is treated ranges from about 39° C. to about 58° C., and may last from about 5 seconds to about 30 minutes. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream to flow through the target site.

Abstract: A system includes a mirror having an axis extending through a central portion thereof, and a portion of the mirror being configured to repeatedly oscillate between a first position and a second position around the axis, so as to record a field of up to 200 degrees of a portion of the central and peripheral retina, a first scanner configured to use a spectral domain optical coherence tomography system to obtain a non-contact wide angle optical coherence tomography-image of the portion of the central and peripheral retina, and a second scanner configured to obtain an image of the retina, wherein the mirror is configured to oscillate so as to move the focal point of the mirror from one side of a pupil to another side, thereby permitting scanning light inside the eye to cover a predetermined peripheral field, thus creating a two dimensional or three dimensional image of the field.

Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells.

Abstract: A method for thermotherapy of a biological tissue by determining the temperature at which to heat a target site to be treated to provide a temperature to the site to effect therapy, the temperature above body temperature but below a protein denaturation temperature, as determined by a patient's experience of a sensation of pain. Thermotherapy is effected in the absence of coagulative effects by providing oscillatory energy at the predetermined temperature.

Abstract: A method of replacing a natural lens in an eye is presented. The method includes removing the natural lens while leaving the capsular bag substantially intact, removing a portion of the capsular bag along the main optical axis, and placing biodendrimer within the capsular bag. Placing biodendrimer within the capsular bag can include placing a mixture of biodendrimer and at least one other material within the capsular bag. Biodendrimer can be approximately fifty percent of the mixture. The method can also include inserting an artificial bag within the capsular bag, injecting a synthetic material into the artificial bag to form an artificial lens, the synthetic material having loose monomers and a polymerization initiator so that the synthetic material changes its volume when exposed to an energy source, and selectively exposing portions of the artificial lens to an energy source to alter the refractive properties of the artificial lens.

Abstract: A system includes a mirror having an axis extending through a central portion thereof, and a portion of the mirror being configured to repeatedly oscillate between a first position and a second position around the axis, so as to record a field of up to 200 degrees of a portion of the central and peripheral retina, a first scanner configured to use a spectral domain optical coherence tomography system to obtain a non-contact wide angle optical coherence tomography-image of the portion of the central and peripheral retina, and a second scanner configured to obtain an image of the retina, wherein the mirror is configured to oscillate so as to move the focal point of the mirror from one side of a pupil to another side, thereby permitting scanning light inside the eye to cover a predetermined peripheral field, thus creating a two dimensional or three dimensional image of the field.

Abstract: An integral laser imaging and coagulation apparatus, and associated systems and methods that allow an ophthalmologist to perform laser retinal surgical procedures with an integral laser imaging and coagulation apparatus disposed at a first (i.e. local) location from a control system disposed at a second (i.e. remote) location, e.g., a physician's office. In some embodiments, communication between the integral laser imaging and coagulation apparatus and control system is achieved via the Internet®.

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The hyperthermia treatment may further comprise platelet-derived treatment. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 56° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: An ultrasonic scanning apparatus that includes a unique ultrasonic array to transmit ultrasonic energy to a biological structure, such as an eye. The ultrasonic array provides specific three-dimensional (3-D) information relating to the eye and precise volumetric information relating to structures associated therewith, such as a tumor, prior, during and/or after treatment. The ultrasonic array can also be combined with a therapeutic ultrasonic unit for real-time 3-D observation of a structure and the focal point of the transmitted therapeutic beam(s) on a monitor during the treatment of a structure, e.g., treatment of a lesion.

Abstract: A method for thermotherapy of a biological tissue by determining the temperature at which to heat a target site to be treated to provide a temperature to the site to effect therapy, the temperature above body temperature but below a protein denaturation temperature, as determined by a patient's experience of a sensation of pain. Thermotherapy is effected in the absence of coagulative effects by providing oscillatory energy at the predetermined temperature.

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 56° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 56° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.

Abstract: The system is able to correct the spherical and cylindrical power as well as other aberrations of the optical pathway of both eyes of a person eliminating the need for multiple heavy glass lenses and mirrors. For correcting the refractive errors, the above described system is equipped with a diachroic mirror interposed in front of the system, to divert part of the light reflecting from the pupil to a Shack-Hartman wave front sensor.

Abstract: A method and device to assess centration of a visual axis, evaluate retinal function, foveal function, and/or visual field.

Abstract: A system for imaging of the central and peripheral retina, includes one of a concave mirror and an elliptical mirror having an axis and being configured to rotate around the axis and a scanner configured to using a spectral domain optical coherence tomography system to obtain a non-contact wide angle OCT-image of a large portion of the central and peripheral retina.

Abstract: A method for surface ablation of cornea tissue comprising the steps of (i) providing a laser source that is adapted to generate and transmit focused pulsed laser energy, the laser source including a delivery head that is adapted to direct the laser energy to a target structure of an eye, (ii) disposing the delivery head a spaced distance from the target eye structure, and (iii) transmitting the laser energy to the target eye structure, whereby the surface of the eye structure tissue is primarily, more preferably, solely ablated.

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 56° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a second ejection end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the ejection end of the elongated agent delivery member. In one embodiment of the invention, the delivery-member comprises a needleless delivery member.

Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a delivery nozzle end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the delivery nozzle end of the elongated agent delivery member with a delivery pressure in the range of approximately 50-1000 psi.