Abstract: A subconjunctival injection apparatus for administering a pharmacological agent formulation to a subconjunctival compartment of an eye, the apparatus including a jet injector having force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the jet injector and through the conjunctiva. In one embodiment of the invention, the jet injector comprises a needleless jet injector. In one embodiment, the needleless jet injector provides a delivery pressure in the range of approximately 100-1000 psi.

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 56° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization of such cells. The cells include retinal and other sensory cells, muscle cells, and nerve cells.

Abstract: A lens system is provided. The lens system includes a lens adapted to be positioned along the main optical axis of the eye and a control unit. The control unit is operable with the lens to alter the focal length of the lens based at least partly upon a condition, such that the lens alters light rays and focuses the rays on the retina of the eye.

Abstract: A lens containing a chromophore distributed in or on the lens such that the lens functions as a virtual pupil in adjusting to light. The lens can be intraocular or extraocular.

Abstract: A method and composition for hyperthermally treating cells in the eye with simultaneous imaging. The heat (temperature) production inside the eye (target) tissue is imaged. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 50° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: A system for measuring intraocular pressure (IOP) of an eye, comprising a plurality of force sensors that are adapted to contact a surface of an eye, means for measuring the forces exerted on the force sensors when in contact with the eye surface, and processing means that is adapted to receive the measured forces and determine IOP of the eye as a function of the measured forces.

Abstract: An ocular device comprising a biodegradable, and absorbable body configured in a shape for implanting directly exterior and anterior to a crystalline lens capsule in a patient's eye shaped in a C configuration or a ring configuration to stably lay on zonules or the anterior lens capsule or an intraocular lens (IOL) between an iris and an outer surface of the lens capsule, or in the choroid shaped in straight rod configuration or in a snake-shaped semicircle configuration to follow the inside curvature of the sclera and readily position inside the suprachoroidal space, or under the retina shaped in a rod configuration or a semicircle configuration the device comprising a deformable material such that the device is folded upon implantation, the device optionally containing an ocular therapeutic agent released upon implanting in the patient's eye.

Abstract: A system for imaging of the central and peripheral retina of an eye, including one of a concave mirror and an elliptical mirror configured to focus a beam of light toward a primary focal point located inside pupil of the eye, and a scanner configured to obtain a non-contact wide angle optical coherence tomography-image of a portion of the central and peripheral retina, the scanner having a probe beam configured to rotate about the primary focal point between a first position and a second position, thereby permitting scanning light inside the eye to cover a predetermined peripheral field, so as to record a field of up to 200 degrees of a portion of the central and peripheral retina, thus creating a two dimensional or three dimensional image of the field.

Abstract: A system for measuring intraocular pressure (IOP) of an eye, comprising a plurality of force sensors that are adapted to contact a surface of an eye, means for measuring the forces exerted on the force sensors when in contact with the eye surface, and processing means that is adapted to receive the measured forces and determine IOP of the eye as a function of the measured forces.

Abstract: Use of topically applied cyclosporine to enhance corneal sensitivity restoration rate in an eye of an individual after ocular surgery such as laser-assisted in situ keratomileusis (LASIK) in which nerves are severed.

Abstract: A system for imaging of the central and peripheral retina, includes one of a concave mirror and an elliptical mirror having an axis and being configured to rotate around the axis and a scanner configured to using a spectral domain optical coherence tomography system to obtain a non-contact wide angle OCT-image of a large portion of the central and peripheral retina.

Abstract: Use of topically applied cyclosporine to enhance corneal sensitivity restoration rate in an eye of an individual after ocular surgery such as laser-assisted in situ keratomileusis (LASIK) in which nerves are severed.

Abstract: A method of testing for an ocular disease in an eye includes measuring a condition of the eye to receive a first value, placing an instrument adjacent the surface of the eye, changing the pressure in the eye using the instrument after measuring the condition, measuring the condition of the eye, after changing the pressure, to receive a second value, and comparing the first value to the second value.

Abstract: A lens containing a chromophore distributed in or on the lens such that the lens functions as a virtual pupil in adjusting to light. The lens can be intraocular or extraocular.

Abstract: The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.

Abstract: A method and device to assess centration of a visual axis, evaluate retinal function, foveal function, and/or visual field.

Abstract: A method of assessing retinal disease in an eye of a patient by rapid, point of care, quantitative detection of cytokine levels is provided.

Abstract: A method for reducing irritancy of ascorbic acid administered to a biological surface for anti-angiogenic, anti-oxidant, anti-inflammatory and other effects. It has been discovered that pH neutralized ascorbic acid retains the efficacy of non-pH neutralized ascorbic acid in reducing neovascularization, providing an anti-oxidant effect, etc. but is less irritating and thus enhances patient comfort and compliance. It may be administered into or on the eye, on skin, into a body cavity, etc. either alone or with other agents.

Abstract: A method and device to assess centration of a visual axis, evaluate retinal function, foveal function, and/or visual field.