Abstract: A meltable smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material and a lipid having a melting point of about 36° C. to about 45° C. An associated process is also provided. The process includes melting a lipid having a melting point of about 36° C. to about 45° C. to form a molten lipid composition, mixing a tobacco material with the molten lipid composition to form a molten smokeless tobacco composition, and cooling the molten smokeless tobacco composition to form a solidified smokeless tobacco composition.

Abstract: A semiconductor device includes a semiconductor layered structure, an electrode unit, and an anti-adsorption layer. The electrode unit is disposed on an electrode connecting region of the semiconductor layered structure. The anti-adsorption layer is disposed on a top surface of the electrode unit opposite to the semiconductor layered structure and is electrically connected to the electrode unit. The anti-adsorption layer has an adsorption capacity for at least one of gaseous contaminants and particulate contaminants which is lower than that of the electrode unit. Also disclosed herein is a light-emitting system including the semiconductor device.

Abstract: A lower limb training rehabilitation apparatus, comprising a weight reducing device, a pelvis supporting device, an exoskeleton device, a control system for controlling mechanical movements of the rehabilitation apparatus, and a treadmill used for walking of a patient. The rehabilitation apparatus hoists the upper body of the patient by means of the weight reducing device, then fixes the crotch of the patient to the pelvis supporting device, and fixes two legs of the patient to two mechanical legs of the exoskeleton device. A power source drives the pelvis supporting device to move up and down, so that the patient can move in the vertical direction; in addition, a sliding base of the pelvis supporting device can assist the patient in moving left and right, swinging left and right, and twisting. The mechanical legs and the treadmill together implement arbitrary movements in six degrees of freedom of the patient.

Abstract: A display device and a method of manufacturing the same are provided. The display device includes a display panel having a display region and a non-display region that are divided in a plane where a light-emitting surface of the display panel is located, a drive circuit plate being disposed on the non-display region; a light transmission layer which is extended from the display region to above the drive circuit plate within the non-display region and has an opening, the opening being adjacent to a boundary of the drive circuit plate close to the display region and being disposed on a side of the drive circuit plate close to the display region.

Abstract: Disclosed is a transcranial magnetic stimulation treatment apparatus applicable to the technical field of medical devices, comprising a TMS coil, a support, a mechanical arm, a controller, and a positioning device. The positioning device detects the position of a human head and the TMS coil and sends positional information to the controller; the controller controls six driving mechanisms of the mechanical arm to rotate to a corresponding angle. Because the mechanical arm has six degrees of freedom, the TMS coil is capable of stimulating each cerebral region of the brain, and the positioning device is capable of detecting an accurate position of the human head, thereby controlling the mechanical arm to accurately position the TMS coil on the human head, and to reduce manual operation.

Abstract: Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroD1 to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroD1, wherein the nucleic acid encoding NeuroD1 is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroD1 such that NeuroD1 is expressed in a mammalian cell.

Abstract: Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.

Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

Abstract: A selenium-enriched tea polyphenol selenide, has such a structure as wherein R1 is alkali metal ion and selenium coordination complex, and R2?H, or A method for preparing the selenium-enriched tea polyphenol selenide, comprises: A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy acid salt; and B) reacting the tea polyphenol hydroxy acid salt with SeO2, to obtain the selenium-enriched tea polyphenol selenide.

Abstract: The present invention relates to a unitary RF connector (1), intended in particular to link two printed circuit boards (PCB1, PCB2), comprising: —a central rigid RF line (A) comprising a conductive element (30, 40, 50) retained within an electrical insulating body (2) which is rigid; —at least one flexible RF line (B1, B2) comprising a conductive element (31, 32; 41, 42; 51, 52) linked to the conductive element (30, 40, 50) of the central rigid line (A) and being able to flex toward one of the end face (21, 22) of the insulating body taking any closer position when acted upon by the pressure force of a complementary connection element (PCB1, PCB2).

Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

Abstract: A gradient amplifier system includes a gradient amplifier for driving a gradient current through the gradient coil. The gradient amplifier includes a gradient filter; a controller coupled to the gradient amplifier for controlling the gradient current in the gradient coil; a feedback loop for feeding only the gradient current in the gradient coil back to the controller. The controller is configured based on only the fedback gradient current in the gradient coil. Filter parameters of the gradient filter are adjusted to achieve a minimum shift between predetermined poles representing a desired performance of the gradient amplifier system and actual poles of a rational transfer function associated with the controller.

Abstract: The invention provides a method, composition, and system for inhibiting sulfide stress cracking of metal that is exposed to aqueous sulfide and aqueous acid, and optionally brine, where the composition comprises a thietane compound, a thiirane compound, or a combination thereof.

Abstract: A selenium-enriched tea polyphenol selenide, has such a structure as: wherein R1 is alkali metal ion and selenium coordination complex, and R2?H, or A method for preparing the selenium-enriched tea polyphenol selenide, comprises: A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy acid salt; and B) reacting the tea polyphenol hydroxy acid salt with SeO2, to obtain the selenium-enriched tea polyphenol selenide.

Abstract: Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.

Abstract: A method for generating a targeted label is provided. An official account in a social network platform is determined by processing circuitry of an apparatus. A plurality of user accounts in the social network platform that follows the official account of the determined provider is determined. Each of the plurality of user accounts has a corresponding user label that indicates a user attribute of a user associated with the respective user account. The plurality of user accounts is added to a set of targeted user accounts. The targeted label for the recommendation information is determined according to the user labels of the plurality of user accounts. Subsequently a set of target user accounts in the social network platform is determined according to the determined targeted label, and the recommendation information is sent to user clients of the user account included in the set of target user accounts.

Abstract: Embodiments of this application provide a method of distributing information from an allocator terminal to a client terminal over a communication network. Information allocation data in an information allocation system is collected by processing circuitry. The information allocation system is configured to allocate the information to a client terminal. The information allocation data includes data associated with a process of allocating the information. Data of actual effect and estimated effect of allocating the information is calculated according to the information allocation data. An allocation instruction is generated according to a comparison between the actual effect data and the corresponding estimated effect data. The allocation instruction is provided to the allocator terminal.

Abstract: A light-emitting diode includes a first semiconductor layer, a light-emitting layer and a second semiconductor layer, having an upper surface providing a first electrode area containing a pad area and an extended area; a transparent conductive layer over the first semiconductor layer having a first opening to expose a portion of a surface of the first semiconductor layer corresponding to the pad area; a protective layer over the transparent conductive layer having a second opening and a third opening respectively at positions corresponding to the pad area and the extended area, while exposing a portion of the surface of the first semiconductor layer corresponding to the pad area and a portion of a surface of the transparent conductive layer corresponding to the extended area; and a first electrode over the protective layer directly contacting the first semiconductor layer corresponding to the pad area via the first and second openings.

Abstract: Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.

Abstract: A method of compressing a texture image for use in generating a 360 degree panoramic video is provided. The method including the steps of: receiving an original texture image for a sphere model, wherein the original texture image is an image with a rectangular shape and includes a plurality of pixel lines and each of the pixels lines has a corresponding spherical position on the sphere model; determining a compression ratio of each of the pixel lines according to the corresponding spherical position of each of the pixel lines; and compressing the pixel lines with the compression ratios corresponding thereto to generate a compressed texture image with a non-rectangular shape, wherein the compressed texture image is further being mapped to the sphere model to generate the 360 degree panoramic video.