Abstract: Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in fruits and honey, is shown herein to potently inhibit neonatal epilepsy both in vitro and in vivo. Sodium gluconate is shown to inhibit epileptiform burst activity in cell cultures and protect neurons from kainic acid-induced cell death. Sodium gluconate also inhibited epileptiform burst activity in brain slices in a manner that was much more potent in neonatal animals than in older animals. Consistently, in vivo EEG recordings also revealed that sodium gluconate inhibited the epileptic seizure activity in a manner that was much more potent in neonates than in adult animals. Mechanistically, sodium gluconate inhibits voltage-dependent CLC-3 Cl? channels both in neuronal cultures and in hippocampal slices.

Abstract: The present invention discloses a method for integrating a vertical nanowire transistor and belongs to a field of field effect transistor logic device in a CMOS ultra-large scale integrated circuit (ULSI). The method realizes the integration of the vertical-nanowire transistor by combining selective epitaxy and replacement gate on sidewall. In comparison with an existing method for forming a vertical nanowire channel by etching, a size and shape of a cross section of a device channel can be accurately controlled, a consistency of device characteristic can be improved, and an etching damage during the forming of a channel in the existing method can be avoided, thereby the device performance can be improved.

Abstract: The disclosure relates to methods and compositions for reducing memory loss. Specifically, methods of using inhibitors of GAT-3 polypeptide activity to reduce memory loss in mammals suffering from Alzheimer's disease (AD) are provided. Further provided are methods for identifying a mammal as having AD by detecting the presence of an elevated level of gamma-aminobutyric acid (GABA) within a mammal's brain.

Abstract: A method for preparing selenium compounds, comprising following steps of: A. hydrolyzing lignin to obtain multiple-structural polyphenolic compounds; B. reacting the multiple-structural polyphenolic compounds with at least one kind of inorganic metal base to obtain multivalent phenolic hydroxyl carboxylate; and C. reacting the multivalent phenolic hydroxyl carboxylate with SeO2 to obtain multivalent phenolic hydroxyl carboxylic acid selenium complex salts, wherein the multivalent phenolic hydroxyl carboxylic acid selenium complex salts are organic selenium composition. The multivalent phenolic hydroxyl carboxylic acid selenium complex salts have characteristics of over 20% selenium content and no toxicity, and have revolutionary effects in killing bacteria, virus and cancer cell, enhancing human immunity, removing oxygen free radicals and etc.

Abstract: The invention provides a method, composition, and system for inhibiting the corrosion of metal that is exposed to aqueous acid, where the composition comprises a thietane compound, a thiirane compound, or a combination thereof.

Abstract: The invention provides a method, composition, and system for inhibiting sulfide stress cracking of metal that is exposed to aqueous sulfide and aqueous acid, and optionally brine, where the composition comprises a thietane compound, a thiirane compound, or a combination thereof.

Abstract: Improved techniques of implementing range lock involve granting a sleeping thread access to an address range when no conflicts exist with earlier pending requests as well as with already granted requests. Along these lines, a current child thread that has a conflict with a parent thread that currently holds a range lock on a range of bytes during a read/write operation will be awoken from waiting state when the parent thread has completed its access and releases its lock. In response, the processor compares the range to which the current child thread request access with the ranges to which other sleeping threads request access. However, the comparisons are only performed in connection with (i) requests that arrived prior to the current child thread and (ii) other granted requests.

Abstract: A compound medicine for treating acute and chronic hepatitis B, includes a polyphenolic selenium compound having a functional group of alkali metal ion and selenium coordination complex, which has functions of directly killing HBV and destroying replication template of HBV. Auxiliary formulas thereof include high-purity oxymatrine and glycyrrhizin sulfate. The oxymatrine has an effect of anti-HBV, and is capable of treating acute and chronic hepatitis B, regulating immune system and increasing leukocyte. Serving as a main hepatocyte membrane protective agent, the glycyrrhizin sulfate has not only an effect of anti-inflammation, but also it is capable of regulating immune system and protecting hepatocyte. The compound medicine has no toxicity or side effect.

Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

Abstract: The present disclosure directs to method, device, system for creating virtual credit card. The method may include: acquiring a subset of real-name information from a user interface of a terminal device; searching the real-name information stored in the first server with the subset of the real-name information; upon the real-name information is found in the first server, sending the real-name user information to a second server; finding whether the real-name information associates with a credit card account stored in the second server; after finding the credit card account is stored in the second server, creating, by the second server, a virtual credit card account; and storing the virtual credit card associated with the virtual credit card account in the data storage of the first server.

Abstract: A GaN-based LED with a current spreading structure, the LED including a substrate, a light-emitting epitaxial layer over the substrate, and a current spreading structure over the light-emitting epitaxial layer. The current spreading structure includes a transparent electrode spreading bar, and a metal electrode spreading bar attached to the side wall of the transparent electrode spreading bar. The current spreading structure can improve the current spreading effect, reducing or eliminating of electrode shading, improving luminous efficiency of the LED, and avoid or reduce high voltage (Vf).

Abstract: A trans-resveratrol selenide for treating cancer has such a structure as: wherein hydroxyls at position 3, 4 and 5 are replaceable, at least one hydroxyl at position 3, 4, 5 is replaced with R, R is alkali metal ion and selenium coordination complex, and The trans-resveratrol selenide preparation is able to treat various cancers, such as lung cancer, lymphoma, stomach cancer, liver cancer, small intestine cancer, colorectal cancer and gynecologic cancer, and has a good curative effect.

Abstract: A meltable smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material and a lipid having a melting point of about 36° C. to about 45° C. An associated process is also provided. The process includes melting a lipid having a melting point of about 36° C. to about 45° C. to form a molten lipid composition, mixing a tobacco material with the molten lipid composition to form a molten smokeless tobacco composition, and cooling the molten smokeless tobacco composition to form a solidified smokeless tobacco composition.

Abstract: A method for preparing selenium compounds, comprising following steps of: A. hydrolyzing lignin to obtain multiple-structural polyphenolic compounds; B. reacting the multiple-structural polyphenolic compounds with at least one kind of inorganic metal base to obtain multivalent phenolic hydroxyl carboxylate; and C. reacting the multivalent phenolic hydroxyl carboxylate with SeO2 to obtain multivalent phenolic hydroxyl carboxylic acid selenium complex salts, wherein the multivalent phenolic hydroxyl carboxylic acid selenium complex salts are organic selenium composition. The multivalent phenolic hydroxyl carboxylic acid selenium complex salts have characteristics of over 20% selenium content and no toxicity, and have revolutionary effects in killing bacteria, virus and cancer cell, enhancing human immunity, removing oxygen free radicals and etc.

Abstract: A compound medicine for treating acute and chronic hepatitis B, includes a polyphenolic selenium compound having a functional group of alkali metal ion and selenium coordination complex, which has functions of directly killing HBV and destroying replication template of HBV. Auxiliary formulas thereof include high-purity oxymatrine and glycyrrhizin sulfate. The oxymatrine has an effect of anti-HBV, and is capable of treating acute and chronic hepatitis B, regulating immune system and increasing leukocyte. Serving as a main hepatocyte membrane protective agent, the glycyrrhizin sulfate has not only an effect of anti-inflammation, but also it is capable of regulating immune system and protecting hepatocyte. The compound medicine has no toxicity or side effect.

Abstract: A display device includes a pixel array. The pixel array includes multiple pixel elements. At least one pixel element includes an OLED, a first transistor, a second transistor, a third transistor, a first capacitor and a second capacitor. The first transistor has a first terminal coupled to an anode of the OLED for driving the OLED. The second transistor is coupled between a second terminal of the first transistor and a reset voltage and has a control terminal receiving a reset signal. The third transistor is coupled between the anode of the OLED and a control terminal of the first transistor and has a control terminal receiving a compensation signal. The first capacitor is coupled between the control terminal of the first transistor and the anode of the OLED. The second capacitor is coupled to the first capacitor and the control terminal of the first transistor.

Abstract: An organic light emitting diode (OLED) based display device including a pixel circuit that includes: an OLED to be connected to a first power terminal, a transistor connected to the OLED, a first capacitor connected to the transistor, a second capacitor connected to the first capacitor and the transistor, a first switch receiving a data signal and a scanning signal and connected to the first capacitor, a second switch connected to the transistor and receiving an enable signal, a third switch connected to the transistor and receiving a compensation signal, and a switching unit configured to transmit one of the enable signal, voltage at a terminal of the first capacitor, a reference signal and the scanning signal to a terminal of the transistor when operated in a conductive state.

Abstract: A light emitting diode includes: a substrate; a light-emitting epitaxial layer, from bottom to up, laminated by semiconductor material layers of a first confinement layer, a light-emitting layer and a second confinement layer over the substrate; a current blocking layer over partial region of the light-emitting epitaxial layer; a transparent conducting structure over the current blocking layer that extends to the light-emitting epitaxial layer surface and is divided into a light-emitting region and a non-light-emitting region, in which, the non-light-emitting region corresponds to the current blocking layer with thickness larger than that of the light-emitting region, thus forming a good ohmic contact between this structure and the light-emitting epitaxial layer and reducing light absorption; and a P electrode over the non-light-emitting region of the transparent conducting structure, which guarantees current spreading performance and reduces working voltage and light absorption.

Abstract: A meltable smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material and a lipid having a melting point of about 36° C. to about 45° C. An associated process is also provided. The process includes melting a lipid having a melting point of about 36° C. to about 45° C. to form a molten lipid composition, mixing a tobacco material with the molten lipid composition to form a molten smokeless tobacco composition, and cooling the molten smokeless tobacco composition to form a solidified smokeless tobacco composition.

Abstract: A light emitting diode includes: a substrate; a light-emitting epitaxial layer, from bottom to up, laminated by semiconductor material layers of a first confinement layer, a light-emitting layer and a second confinement layer over the substrate; a current blocking layer over partial region of the light-emitting epitaxial layer; a transparent conducting structure over the current blocking layer that extends to the light-emitting epitaxial layer surface and is divided into a light-emitting region and a non-light-emitting region, in which, the non-light-emitting region corresponds to the current blocking layer with thickness larger than that of the light-emitting region, thus forming a good ohmic contact between this structure and the light-emitting epitaxial layer and reducing light absorption; and a P electrode over the non-light-emitting region of the transparent conducting structure, which guarantees current spreading performance and reduces working voltage and light absorption.