Patents by Inventor Gordana Vunjak-Novakovic

Gordana Vunjak-Novakovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190276785
    Abstract: A bioreactor is provided that permits engineering of multiple different tissues. The bioreactor has a series of flow paths that permit application of tissue-specific media while simultaneously innervating the various different tissues with a common media. The flow paths for the various medias are designed to prevent mixing of the various media as they simultaneously innervate the tissue.
    Type: Application
    Filed: January 11, 2019
    Publication date: September 12, 2019
    Inventors: Gordana Vunjak-Novakovic, Keith Yeager, Kacey Ronaldson, Stephen Ma, Timothy Chen
  • Publication number: 20190225925
    Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Sarindr Bhumiratana, Keith Yeager
  • Publication number: 20190224364
    Abstract: Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.
    Type: Application
    Filed: April 1, 2019
    Publication date: July 25, 2019
    Inventors: Matthew Bacchetta, Brandon Guenthart, Jinho Kim, John O'Neill, Gordana Vunjak-Novakovic
  • Patent number: 10301584
    Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: May 28, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gordana Vunjak-Novakovic, Sarindr Bhumiratana, Keith Yeager
  • Publication number: 20190141985
    Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.
    Type: Application
    Filed: January 10, 2019
    Publication date: May 16, 2019
    Inventors: Matthew Bacchetta, Scott Chicotka, Kenmond Fung, Brandon Guenthart, John O'Neill, Gordana Vunjak-Novakovic
  • Publication number: 20190031991
    Abstract: The present disclosure relates to a pneumatic microfluidic platform for high-throughput studies of cardiac hypertrophy that enables repetitive (hundreds of thousands of times) and robust (over several weeks) manipulation of cardiac ?tissues. The platform is reusable for stable and reproducible mechanical stimulation of cardiac ?tissues (each containing only 500 cells). Heterotypic and homotypic ?tissues produced in the device were pneumatically loaded in a range of regimes, with real-time on-chip analysis of tissue phenotypes. Concentrated loading of the three-dimensional cardiac tissue faithfully recapitulated the pathology of volume overload seen in native heart tissue. Sustained volume overload of ?tissues was sufficient to induce pathological cardiac remodeling associated with upregulation of the fetal gene program, in a dose-dependent manner.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 31, 2019
    Inventors: Gordana Vunjak-Novakovic, Hesam Parsa
  • Publication number: 20190008923
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: May 17, 2018
    Publication date: January 10, 2019
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20180371415
    Abstract: A 3D decellularized bone scaffold seeded with cancer cells, such as prostate cancer cells or Ewing's sarcoma is provided. The three-dimensional includes Ewing's sarcoma (ES) tumor cells; and an engineered human bone scaffold. The engineered human bone scaffold further includes osteoblasts that secrete substance of the human bone, and osteoclasts that absorb bone tissue during growth and healing. The engineered human bone scaffold includes the tissue engineered three-dimensional model which recapitulates the osteolytic process. The engineered human bone scaffold is engineered by co-culturing of osteoblasts and osteoclasts. The osteoblast is produced by cell differentiation process from mesenchymal stem cells. The osteoclast is produced by cell differentiation from human monocytes, wherein the human monocytes are isolated from buffy coats.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Inventors: Gordana Vunjak-Novakovic, Aranzazu Villasante
  • Publication number: 20180256642
    Abstract: Region-specific extracellular matrix (ECM) biomaterials are provided. Such materials include acellular scaffolds, sponges, solutions, and hydrogels suitable for stem cell culture.
    Type: Application
    Filed: March 6, 2018
    Publication date: September 13, 2018
    Inventors: Donald O. Freytes, Gordana Vunjak-Novakovic, John O'Neill
  • Patent number: 9993527
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: June 12, 2018
    Assignees: TRUSTEES OF TUFTS COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Patent number: 9958436
    Abstract: Methods for determining cell chirality using micropatterned substrates are disclosed. Also provided are methods for diagnosing diseases such as genetic diseases or cancer by comparing the chirality of sample cells from a subject with normal cells, and determining a difference in chirality between the sample cells and normal cells.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: May 1, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gordana Vunjak-Novakovic, Leo Qun Wan
  • Patent number: 9888680
    Abstract: The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: February 13, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Joshua Sonett, John O'Neill, Matthew Bacchetta, Donald O. Freytes, Gopal Singh, Scott A. Kanner
  • Publication number: 20170333597
    Abstract: Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.
    Type: Application
    Filed: July 21, 2017
    Publication date: November 23, 2017
    Inventors: Sarindr Bhumiratana, Gordana Vunjak-Novakovic
  • Patent number: 9808557
    Abstract: Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: November 7, 2017
    Assignees: Trustees of Tufts College, The Trustees of Columbia University in the City of New York, Massachussets Institute of Technology
    Inventors: Michael L. Lovett, Xianyan Wang, Christopher M. Cannizzaro, Gordana Vunjak-Novakovic, David L. Kaplan
  • Publication number: 20170290665
    Abstract: An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 12, 2017
    Inventors: Gordana Vunjak-Novakovic, Warren Grayson, Keith Yeager
  • Patent number: 9687348
    Abstract: An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: June 27, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gordana Vunjak-Novakovic, Warren L. Grayson, Keith Yeager
  • Publication number: 20170002330
    Abstract: A cardiac organoid containing 3-D matter of adult human heart tissue.
    Type: Application
    Filed: May 11, 2016
    Publication date: January 5, 2017
    Inventors: Gordana Vunjak-Novakovic, Keith Yeager, Kacey Ronaldson, Stephen Ma, Timothy Chen
  • Publication number: 20160199450
    Abstract: The present disclosure provides biocompatible scaffold that promotes M1 or M2 macrophage phenotypes so as to increase vascularization or healing. Also provided are methods of treating a subject in need with the scaffolds described here.
    Type: Application
    Filed: August 26, 2014
    Publication date: July 14, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Kara Lorraine Spiller
  • Publication number: 20160168542
    Abstract: A 3D decellularized bone scaffold seeded with cancer cells, such as prostate cancer cells or Ewing's sarcoma is provided. It provides platform technology for controllable, quantitative, long-term studies of tissue-engineered tumors, including prostate cancer and Ewing's sarcoma. The scaffold can be used with cancer cell lines to identify therapeutic targets to slow, stop, and reverse tumor growth and progression as well as to predict the efficacy of potential therapeutics.
    Type: Application
    Filed: August 1, 2014
    Publication date: June 16, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNICERSITY IN THE CITY OF NEW YORK
    Inventors: Aranzazu Villasante, Gordana Vunjak-Novakovic
  • Publication number: 20160131636
    Abstract: An integrated system for detecting safety and/or efficacy issues related to potential drug compounds by combining tissue maturation, imaging and electrophysiology measurements, at high throughput, with high signal to noise ratio. Testing includes cardiotoxicity screening, drug screening, and screening for cardiogenic factors via on-line physiological measurements.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 12, 2016
    Inventors: Nina TANDON, Elisa CIMETTA, Kacey RONALDSON, Gordana VUNJAK-NOVAKOVIC