Patents by Inventor Gordana Vunjak-Novakovic

Gordana Vunjak-Novakovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9290579
    Abstract: The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: March 22, 2016
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: Charu Vepari, David L. Kaplan, Gordana Vunjak-Novakovic
  • Publication number: 20160053214
    Abstract: Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
    Type: Application
    Filed: November 2, 2015
    Publication date: February 25, 2016
    Inventors: Gordana VUNJAK-NOVAKOVIC, Warren GRAYSON, Qun WAN, Donald O. FREYTES, Amandine GODIER-FURNEMONT, Nina TANDON, Keith YEAGER, George ENG, Sarindr BHUMIRATANA, Robert MAIDHOF
  • Publication number: 20160040108
    Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.
    Type: Application
    Filed: April 17, 2014
    Publication date: February 11, 2016
    Inventors: Gordana Vunjak-Novakovic, Sarindr Bhumiratana, Keith Yeager
  • Patent number: 9206383
    Abstract: Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: December 8, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gordana Vunjak-Novakovic, Warren Grayson, Qun Wan, Donald O. Freytes, Amandine Godier-Furnémont, Nina Tandon, Keith Yeager, George Eng, Sarindr Bhumiratana, Robert Maidhof
  • Patent number: 9132197
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: September 15, 2015
    Assignees: Massachusetts Institute of Technology, Trustees of Tufts College
    Inventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Patent number: 9068282
    Abstract: A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: June 30, 2015
    Assignees: Trustees of Tufts College, The Trustees of Columbia University in the City of New York
    Inventors: Christopher Cannizzaro, Michael L. Lovett, Gordana Vunjak-Novakovic, David L. Kaplan
  • Publication number: 20150037434
    Abstract: Region-specific extracellular matrix (ECM) biomaterials are provided. Such materials include acellular scaffolds, sponges, solutions, and hydrogels suitable for stem cell culture.
    Type: Application
    Filed: August 1, 2014
    Publication date: February 5, 2015
    Inventors: Donald O. Freytes, Gordana Vunjak-Novakovic, John O'Neill
  • Publication number: 20150004643
    Abstract: Methods for determining cell chirality using micropatterned substrates are disclosed. Also provided are methods for diagnosing diseases such as genetic diseases or cancer by comparing the chirality of sample cells from a subject with normal cells, and determining a difference in chirality between the sample cells and normal cells.
    Type: Application
    Filed: June 15, 2012
    Publication date: January 1, 2015
    Applicant: The Trustees of Columbia University in the city of New york
    Inventors: Gordana Vunjak-Novakovic, Leo Qun Wan
  • Publication number: 20140322696
    Abstract: The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.
    Type: Application
    Filed: April 4, 2014
    Publication date: October 30, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: GORDANA VUNJAK-NOVAKOVIC, JOSHUA SONETT, JOHN O'NEILL, MATTHEW BACCHETTA, DONALD O. FREYTES, GOPAL SINGH, SCOTT A. KANNER
  • Publication number: 20140094410
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: November 19, 2012
    Publication date: April 3, 2014
    Inventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20130230491
    Abstract: The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
    Type: Application
    Filed: February 25, 2013
    Publication date: September 5, 2013
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, TRUSTEES OF TUFTS COLLEGE
    Inventors: Charu Vepari, David L. Kaplan, Gordana Vunjak-Novakovic
  • Patent number: 8367410
    Abstract: The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: February 5, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Milica Radisic, Hyoungshin Park, Robert Langer, Lisa Freed, Gordana Vunjak-Novakovic
  • Patent number: 8361617
    Abstract: The present application provides a composition comprising porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffold described herein can be adjusted to mimic the gradient of densities found in natural tissue.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: January 29, 2013
    Assignees: Trustees of Tufts College, Massachusetts Institue of Technology
    Inventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20120123519
    Abstract: Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
    Type: Application
    Filed: August 11, 2008
    Publication date: May 17, 2012
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, TRUSTEES OF TUFTS COLLEGE
    Inventors: Michael L. Lovett, Xianyan Wang, Christopher M. Cannizzaro, Gordana Vunjak-Novakovic, David L. Kaplan
  • Publication number: 20120035742
    Abstract: An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
    Type: Application
    Filed: March 3, 2010
    Publication date: February 9, 2012
    Inventors: Gordana Vunjak-Novakovic, Warren L. Grayson, Keith Yeager
  • Publication number: 20110136225
    Abstract: Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
    Type: Application
    Filed: December 6, 2010
    Publication date: June 9, 2011
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Warren Grayson, Qun Wan, Donald Freytes, Amandine Godier-Furnémont, Nina Tandon, Keith Yeager, George Eng, Sarindr Bhumiratana, Robert Maidhof
  • Publication number: 20110076384
    Abstract: A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
    Type: Application
    Filed: April 8, 2009
    Publication date: March 31, 2011
    Applicants: TRUSTEES OF TUFTS COLLEGE, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Christopher Cannizzaro, Michael L. Lovett, Gordana Vunjak-Novakovic, David L. Kaplan
  • Patent number: 7842780
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: November 30, 2010
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20100279112
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: July 15, 2010
    Publication date: November 4, 2010
    Applicants: TRUSTEES OF TUFTS COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20090043389
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.
    Type: Application
    Filed: August 14, 2008
    Publication date: February 12, 2009
    Inventors: GORDANA VUNJAK-NOVAKOVIC, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Katherine G. Truncale