Patents by Inventor Gordana Vunjak-Novakovic

Gordana Vunjak-Novakovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080274157
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.
    Type: Application
    Filed: March 26, 2008
    Publication date: November 6, 2008
    Inventors: Gordana Vunjak-Novakovic, Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman
  • Publication number: 20070212730
    Abstract: The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/ or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
    Type: Application
    Filed: April 19, 2006
    Publication date: September 13, 2007
    Applicants: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: Charu Vepari, David Kaplan, Gordana Vunjak-Novakovic
  • Patent number: 7252982
    Abstract: Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissue site. If the matrix is biodegradable, the metabolic result may include resorption of the matrix and replacement with tissue synthesized at least in part by the transfected cells.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: August 7, 2007
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Henning Madry, Gordana Vunjak-Novakovic, Stephen B. Trippel, Lisa E. Freed, Robert Langer
  • Publication number: 20070122392
    Abstract: Embryonic stem cells are propagated in a hyaluronic acid.
    Type: Application
    Filed: June 22, 2006
    Publication date: May 31, 2007
    Inventors: Sharon Gerecht-Nir, Jason Burdick, Gordana Vunjak-Novakovic, Robert Langer
  • Publication number: 20060273279
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: January 7, 2004
    Publication date: December 7, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: David Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20050222687
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.
    Type: Application
    Filed: April 2, 2004
    Publication date: October 6, 2005
    Inventors: Gordana Vunjak-Novakovic, Katherine Truncale, Moon Hae Sunwoo, Arthur Gertzman, William Tomford
  • Publication number: 20050112759
    Abstract: The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.
    Type: Application
    Filed: June 21, 2004
    Publication date: May 26, 2005
    Inventors: Milica Radisic, Hyoungshin Park, Robert Langer, Lisa Freed, Gordana Vunjak-Novakovic
  • Publication number: 20050074477
    Abstract: The invention relates to a tissue replacement structure comprising (a) a preformed three-dimensional tissue which can be produced by obtaining cells from a human or animal organism and culturing them in a stationary fashion as a suspension culture in cell culture vessels with hydrophobic surface and tapering bottom until a cell aggregate is formed which has differentiated cells embedded therein and has an outer region wherein cells capable of proliferation and migration are present; (b) (i) an autologous cell suspension which can be produced from endogenous cells, with endogenous serum being added, with no addition of growth-promoting compounds, (ii) implants or support materials and/or (iii) growth factors; and/or (c) can be obtained by exposure of the tissue according to (a) to electromagnetic fields, mechanical stimulation and/or ultrasound.
    Type: Application
    Filed: November 7, 2003
    Publication date: April 7, 2005
    Inventors: Olivera Josimovic-Alasevic, Jeannette Libera, Hans-Peter Wiesmann, Ulrich Joos, Gordana Vunjak-Novakovic
  • Publication number: 20050064042
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.
    Type: Application
    Filed: October 12, 2004
    Publication date: March 24, 2005
    Inventors: Gordana Vunjak-Novakovic, Katherine Ann Truncale, Moon Sunwoo, Arthur Gertzman
  • Publication number: 20050037952
    Abstract: Compositions and methods comprising at least one active agent chosen from TGF-P superfamily proteins, including BMPs, and GDFs for increasing the growth rate or modulating the development of engineered cartilage are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects, and in related tissue repair.
    Type: Application
    Filed: June 9, 2003
    Publication date: February 17, 2005
    Inventors: Lisa Freed, Keith Gooch, Donald Courter, Torsten Blunk, Alisha Sieminski, Gordana Vunjak-Novakovic
  • Publication number: 20040219659
    Abstract: The invention features a bioreactor system. The system includes components, which exert physiologically relevant translational and rotational strains on a growing bioengineered tissue.
    Type: Application
    Filed: April 22, 2003
    Publication date: November 4, 2004
    Inventors: Gregory H. Altman, Gordana Vunjak-Novakovic, Peter R. H. Stark
  • Patent number: 6582960
    Abstract: The present invention provides an improved method for expanding cells for use in tissue engineering. In particular the method provides specific biochemical factors to supplement cell culture medium during the expansion process in order to reproduce events occurring during embryonic development with the goal of regenerating tissue equivalents that resemble natural tissues both structurally and functionally. These specific biochemical factors improve proliferation of the cells and are capable of de-differentiation mature cells isolated from tissue so that the differentiation potential of the cells is preserved. The bioactive molecules also maintain the responsiveness of the cells to other bioactive molecules. Specifically, the invention provides methods for expanding chondrocytes in the presence of fibroblast growth factor 2 for use in regeneration of cartilage tissue.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: June 24, 2003
    Assignee: Massachusetts Institute of Technology
    Inventors: Ivan Martin, Lisa E. Freed, Robert Langer, Gordana Vunjak-Novakovic
  • Publication number: 20020177224
    Abstract: Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissue site.
    Type: Application
    Filed: March 15, 2001
    Publication date: November 28, 2002
    Inventors: Henning Madry, Gordana Vunjak-Novakovic, Stephen B. Trippel, Lisa E. Freed, Robert Langer
  • Publication number: 20020062151
    Abstract: The present invention provides a method for producing an anterior cruciate ligament ex vivo. The method comprises seeding pluripotent stem cells in a three dimensional matrix, anchoring the seeded matrix by attachment to two anchors, and culturing the cells within the matrix under conditions appropriate for cell growth and regeneration, while subjecting the matrix to one or more mechanical forces via movement of one or both of the attached anchors. Bone marrow stromal cells are preferably used as the pluripotent cells in the method. Suitable matrix materials are materials to which cells can adhere, such as a gel made from collagen type I. Suitable anchor materials are materials to which the matrix can attach, such as Goinopra coral and also demineralized bone. Some examples of tissue which can be produced include other ligaments in the body (hand, wrist, elbow, knee), tendon, cartilage, bone, muscle, and blood vessels.
    Type: Application
    Filed: September 10, 2001
    Publication date: May 23, 2002
    Inventors: Gregory Altman, David Kaplan, Gordana Vunjak-Novakovic, Ivan Martin
  • Patent number: 6287340
    Abstract: The present invention provides a method for producing an anterior cruciate ligament ex vivo. The method comprises seeding pluripotent stem cells in a three dimensional matrix, anchoring the seeded matrix by attachment to two anchors, and culturing the cells within the matrix under conditions appropriate for cell growth and regeneration, while subjecting the matrix to one or more mechanical forces via movement of one or both of the attached anchors. Bone marrow stromal cells are preferably used as the pluripotent cells in the method. Suitable matrix materials are materials to which cells can adhere, such as a gel made from collagen type I. Suitable anchor materials are materials to which the matrix can attach, such as Goinopra coral and also demineralized bone. Optimally, the mechanical forces to which the matrix is subjected mimic mechanical stimuli experienced by an anterior cruciate ligament in vivo.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: September 11, 2001
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: Gregory Altman, David Kaplan, Gordana Vunjak-Novakovic, Ivan Martin