Patents by Inventor Gordon Bruce Collier
Gordon Bruce Collier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10746749Abstract: The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.Type: GrantFiled: March 6, 2018Date of Patent: August 18, 2020Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Paul Willis Johns, Smitha R K Sutrala, Dan Wang, Katrina Petronilla Di Tullio
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Publication number: 20180196072Abstract: The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.Type: ApplicationFiled: March 6, 2018Publication date: July 12, 2018Applicant: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Paul Willis Johns, Smitha RK Sutrala, Dan Wang, Katrina Petronilla Di Tullio
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Patent number: 9921232Abstract: The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.Type: GrantFiled: September 25, 2015Date of Patent: March 20, 2018Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Paul Willis Johns, Jr., Smitha R K Sutrala, Dan Wang, Katrina Petronilla Di Tullio
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Patent number: 9835620Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: GrantFiled: August 4, 2015Date of Patent: December 5, 2017Assignee: IBIS BIOSCIENCES, INC.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Publication number: 20170275687Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition.Type: ApplicationFiled: June 5, 2017Publication date: September 28, 2017Inventors: Jeffrey Huff, Graham Davis, Mark Hayden, David J. Ecker, Dan Wang, Gordon Bruce Collier
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Patent number: 9752182Abstract: The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: GrantFiled: August 28, 2014Date of Patent: September 5, 2017Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Patent number: 9670538Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode. Moreover, in some embodiments the device further comprises a reference electrode. Performing the sequencing reaction involves moving solutions and other fluids (e.g., samples, nucleotide solutions, wash solutions) into and out of the reaction vessel. Thus, in some embodiments, the device further comprises a tube or other transport mechanism or pathway attached to the reaction vessel.Type: GrantFiled: August 3, 2012Date of Patent: June 6, 2017Assignee: IBIS BIOSCIENCES, INC.Inventors: Jeffrey Huff, Graham Davis, Mark Hayden, David J. Ecker, Dan Wang, Gordon Bruce Collier
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Patent number: 9575076Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: GrantFiled: October 29, 2015Date of Patent: February 21, 2017Assignee: Abbott Point of Care Inc.Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Patent number: 9575077Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: GrantFiled: October 30, 2015Date of Patent: February 21, 2017Assignee: Abbott Point of Care Inc.Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Patent number: 9441259Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: November 21, 2014Date of Patent: September 13, 2016Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20160109465Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: ApplicationFiled: October 29, 2015Publication date: April 21, 2016Applicant: Abbott Point of Care Inc.Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Publication number: 20160109466Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: ApplicationFiled: October 30, 2015Publication date: April 21, 2016Applicant: Abbott Point of Care Inc.Inventors: Dan WANG, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Publication number: 20160091512Abstract: The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.Type: ApplicationFiled: September 25, 2015Publication date: March 31, 2016Inventors: Gordon Bruce Collier, Paul Willis Johns, JR., Smitha RK Sutrala, Dan Wang, Katrina Petronilla Di Tullio
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Publication number: 20160077085Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: ApplicationFiled: August 4, 2015Publication date: March 17, 2016Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Publication number: 20160047800Abstract: A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.Type: ApplicationFiled: October 30, 2015Publication date: February 18, 2016Inventors: Gordon Bruce Collier, Cary James Miller
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Patent number: 9199234Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: GrantFiled: November 29, 2011Date of Patent: December 1, 2015Assignee: Abbott Point of Care Inc.Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Patent number: 9201078Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: GrantFiled: November 29, 2011Date of Patent: December 1, 2015Assignee: Abbott Point of Care Inc.Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Publication number: 20150275261Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: ApplicationFiled: November 21, 2014Publication date: October 1, 2015Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 9097711Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to methods for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to methods employing an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: GrantFiled: December 10, 2013Date of Patent: August 4, 2015Assignee: IBIS BIOSCIENCES, INC.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8986526Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: December 12, 2012Date of Patent: March 24, 2015Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth