Patents by Inventor Gordon Bruce Collier
Gordon Bruce Collier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150064707Abstract: The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: ApplicationFiled: August 28, 2014Publication date: March 5, 2015Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20150045239Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: ApplicationFiled: December 10, 2013Publication date: February 12, 2015Applicant: Ibis Biosciences, Inc.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8883487Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing.Type: GrantFiled: December 21, 2005Date of Patent: November 11, 2014Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20140238859Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode. Moreover, in some embodiments the device further comprises a reference electrode. Performing the sequencing reaction involves moving solutions and other fluids (e.g., samples, nucleotide solutions, wash solutions) into and out of the reaction vessel. Thus, in some embodiments, the device further comprises a tube or other transport mechanism or pathway attached to the reaction vessel.Type: ApplicationFiled: August 3, 2012Publication date: August 28, 2014Applicant: IBIS BIOSCIENCES, INC.Inventors: Jeffrey Huff, Graham Davis, Mark Hayden, David J. Ecker, Dan Wang, Gordon Bruce Collier
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Patent number: 8703445Abstract: The present invention relates to automated devices and methods for the amplification of segments of nucleic acid in a convenient and portable manner. A single-use nucleic acid amplification device for producing an amplicon includes a housing and an amplification chamber. The chamber includes an ingress with a first reversible seal, an egress with a second reversible seal, a sealable sample entry orifice, and a first wall forming a portion of the chamber. The first wall includes a thermally conductive material and includes an interior surface and an exterior surface. The exterior surface includes a heating circuit and a temperature sensor. The sample entry orifice permits a sample of nucleic acid to enter the amplification chamber. The ingress is connected to a first conduit along with a pneumatic pump and a fluid pouch. The egress is connected to a second conduit permitting egress of the amplicon from the amplification chamber.Type: GrantFiled: December 15, 2006Date of Patent: April 22, 2014Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew MacLeod, Attila Csaba Nemeth, William Charles Dicke
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Patent number: 8617826Abstract: Thyroid Stimulating Hormone (TSH) immunoassays are performed using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine glycoprotein hormone analogues such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: GrantFiled: November 29, 2011Date of Patent: December 31, 2013Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Emegbero Omakor
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Patent number: 8614087Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: GrantFiled: May 2, 2012Date of Patent: December 24, 2013Assignee: Ibis Biosciences, Inc.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8445199Abstract: A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.Type: GrantFiled: December 30, 2009Date of Patent: May 21, 2013Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Cary James Miller
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Patent number: 8389042Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: May 23, 2012Date of Patent: March 5, 2013Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20120301906Abstract: The invention relates to Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine glycoprotein hormone analogues such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: ApplicationFiled: November 29, 2011Publication date: November 29, 2012Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, John Emegbero Omakor
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Publication number: 20120301896Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).Type: ApplicationFiled: November 29, 2011Publication date: November 29, 2012Applicant: ABBOTT POINT OF CARE INC.Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
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Publication number: 20120282602Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: ApplicationFiled: May 2, 2012Publication date: November 8, 2012Applicant: IBIS BIOSCIENCES, INC.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Publication number: 20120270756Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: ApplicationFiled: May 23, 2012Publication date: October 25, 2012Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8268604Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: December 20, 2007Date of Patent: September 18, 2012Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8241697Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: December 20, 2007Date of Patent: August 14, 2012Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8048633Abstract: The invention relates to a method for the extraction of nucleic acid from cells, the amplification of segments of nucleic acid using modified primers, and the detection of nucleic acids.Type: GrantFiled: June 29, 2010Date of Patent: November 1, 2011Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Patent number: 8017340Abstract: The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: GrantFiled: July 29, 2010Date of Patent: September 13, 2011Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100330575Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: ApplicationFiled: June 29, 2010Publication date: December 30, 2010Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100297708Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: ApplicationFiled: July 29, 2010Publication date: November 25, 2010Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100291666Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing.Type: ApplicationFiled: December 21, 2005Publication date: November 18, 2010Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller