Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.

Abstract: A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.

Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.

Abstract: The present invention relates to automated devices and methods for the amplification of segments of nucleic acid in a convenient and portable manner. A single-use nucleic acid amplification device for producing an amplicon includes a housing and an amplification chamber. The chamber includes an ingress with a first reversible seal, an egress with a second reversible seal, a sealable sample entry orifice, and a first wall forming a portion of the chamber. The first wall includes a thermally conductive material and includes an interior surface and an exterior surface. The exterior surface includes a heating circuit and a temperature sensor. The sample entry orifice permits a sample of nucleic acid to enter the amplification chamber. The ingress is connected to a first conduit along with a pneumatic pump and a fluid pouch. The egress is connected to a second conduit permitting egress of the amplicon from the amplification chamber.

Abstract: The present invention describes a novel business model for performing Research and Development Information Technology Application Software Hosting using remote computing resources. A client computer user is provided access to a state-of-the-art remote computing facility and applications running on servers at this remote computing facility, which are secure, environmentally stabilized and properly managed. The computer user's application is available via a secure data line either through a private Intranet link or using encrypted data over the Internet, using a thin-client type environment. This environment can be expanded wherein access to extremely fast processors can be managed by porting the user environment to a fast processor system employing a means that is essentially transparent to the user. The model provides hardware, software and data product installation, maintenance, support, backup and other services for the client.

Abstract: A new method for staining biomolecules is described wherein a prepared gelled matrix containing the desired stain is applied onto the biomolecules such that the stain is transferred from the gelled matrix to the biomolecules. This method eliminates the potential hazard of exposing the technician or researcher to the staining solution itself and avoids environmental contamination resulting from the disposal of the staining solution in the water supply.