Abstract: The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.

Abstract: Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

Abstract: A drug-delivery system is provided including at least 100 ?g of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 ?g, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).

Abstract: The system and method of the invention describes a unique approach to gathering patient treatment information in summary form from a universe of health care providers, each using any form of patient information management; converting that information to pointers that can be searched by a healthcare provider before or during treatment to determine if further information needs to be acquired from the original provider; and a variety of methods to provide access to detailed healthcare treatment and diagnosis information from the original healthcare provider through an access and display method provided by the healthcare provider housing the records, if available. The system and method envisages one or more providers of repository services, each offering various ways for healthcare providers to update and maintain summary information, and each providing for continual exchange of information among them to ensure complete access to all available information.

Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.

Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.

Abstract: Provided herein is a method of controlling release rate of a bioactive agent from an implantable medical device comprising a coating, a coating on the implantable device and a method of making the coating.

Abstract: A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

Abstract: Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

Abstract: A system and method for encoding data for transmission over a telecommunications network. The system and method involve embedding a control data block (Ik0) within a plurality of real data blocks (IN0). Preferably, real data in the real data blocks (INO) is convoluted with at least some of the control data in the control data block (Ik0) For example, each entry in each real data block (INO) may be phase convoluted with phase angle of the corresponding entry in the control block using an encoding module. Once this is done, the real data in the real data blocks and additionally the control data block in the control block is modulated with every sub carrier.

Abstract: Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.

Abstract: A technique for controlling an irrigation system is disclosed. The technique comprises receiving landscape information, receiving environmental information, deriving an irrigation schedule based on the landscape information and the environmental information, and sending the irrigation schedule to an irrigation control unit.

Abstract: A process and apparatus for detecting underwater objects comprises an elongate array of ultrasound transmitter elements mounted substantially vertically and forward facing on the bow of the ship from which is transmitted a sequence of ultrasound wave pulses, with each pulse having a frequency and vertical beam angle which are different to the frequency and vertical beam angle of the preceding pulse in the sequence, the frequency being characteristic of the vertical beam angle and the vertical beam angle being controlled by using time delays between different transmitter elements, and an elongate array of ultrasound receiver elements mounted substantially horizontally on the bow of said ship with the receiver elements forward facing which receive any ultrasound waves reflected from objects in front of the ship, the output from the receiver elements being steered horizontally using time delays between different receiver element outputs and for each horizontal position of the beam of outputs, the outputs from th

Abstract: A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.

Abstract: A technique for controlling an irrigation system is disclosed. The technique comprises receiving landscape information, receiving environmental information, deriving an irrigation schedule based on the landscape information and the environmental information, and sending the irrigation schedule to an irrigation control unit.

Abstract: Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.