Abstract: Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.

Abstract: The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.

Abstract: A drug-delivery system is provided including at least 100 ?g of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 ?g, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).

Abstract: A technique for controlling an irrigation system is disclosed. The technique comprises receiving landscape information, receiving environmental information, deriving an irrigation schedule based on the landscape information and the environmental information, and sending the irrigation schedule to an irrigation control unit.

Abstract: The present invention relates to implantable medical devices coated with the polymer containing at least an olimus and a corticosteroid for the treatment of vascular diseases.

Abstract: Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

Abstract: Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.

Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.

Abstract: Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.

Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.

Abstract: An implantable medical device including a polymer matrix containing everolimus and pimecrolimus, and methods of using the device for the treatment of vascular disease are disclosed.

Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.

Abstract: Processes and systems for providing analytical device analysis advisory information are provided. Aspects of the subject processes and systems include use of an advisory module that generates analytical device analysis advisory information based on a sample identifier and instrument parameter. Also provided are computer program products for use in executing the subject processes.

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.