Patents by Inventor Graham Holmwood
Graham Holmwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4960456Abstract: Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents a substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cyclo-alkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.Type: GrantFiled: May 19, 1989Date of Patent: October 2, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes, Volker Paul
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Patent number: 4960453Abstract: Fungicidal and plant growth-regulating hydroxyalkylazolyl derivatives of the formula ##STR1## in which Z represents halogen, alkyl with 1 to 4 carbon atoms, halogenoalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio with 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl or alkoximinomethyl with 1 to 4 carbon atoms in the alkoxy group,X represents oxygen, sulphur or a CH.sub.2 group andm represents the number 0, 1, 2 or 3,and addition products thereof with acids and metal salts. Intermediates of the formulas ##STR2## are also new.Type: GrantFiled: May 5, 1988Date of Patent: October 2, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Gerhard Jager, Karl H. Buchel, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler
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Patent number: 4960781Abstract: Fungicidal bisazolyl-hydroxyalkyl derivatives of the formula ##STR1## in which Ar stands for optionally substituted aryl,X stands for a grouping --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 -- or --SH.dbd.CH--,Y stands for a nitrogen atom or the grouping CR.sup.3,R.sup.1, R.sup.2 and R.sup.3 stand for hydrogen, halogen or methyl, andn stands for the numbers 0, 1 or 2,and acid addition salts and metal salt complexes thereof. Intermediates of the formulas ##STR2## are also new.Type: GrantFiled: February 16, 1990Date of Patent: October 2, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Wolfgang Kramer, Erik Regel, Hans L. Elbe, Karl H. Buchel, Stefan Dutzmann, Wilhelm Brandes, Paul Reinecke
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Patent number: 4952595Abstract: Novel heterocyclic amide derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, or represents alkenyl which has more than 2 carbon atoms and is optionally substituted by halogen, or represents alkinyl which has more than 2 carbon atoms and is optionally substituted by halogen, or represents alkoxyalkyl or alkylthioalkyl;R.sup.2 represents optionally substituted naphtyl, or represents optionally substituted tetrahydronaphthyl, or represents optionally substituted indanyl;A represents an alkylene bridge, or also an alkenylene bridge if X denotes a direct bond;X represents oxygen, sulphur or a direct bond;Y represents oxygen or sulphur;B represents imidazol-1-yl, pyridin-3-yl, pyrazin-2-yl, pyrimidin-5-yl, 1,2,4-triazol-1-yl or 1-methyl-imidazol-5-yl;and their acid addition salts and metal salt complexes, are outstandingly active as fungicides.Type: GrantFiled: September 26, 1988Date of Patent: August 28, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Joachim Weissmuller, Wilhelm Brandes, Paul Reinecke
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Patent number: 4933358Abstract: Synergistic fungicidal compositions comprising (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which R.sup.1, R.sup.2, X, Y and A have various meanings, or addition products thereof with acids or metal salts, and (ii) at least one of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a guanidine derivative,(D) an aromatic acid lactone,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclic compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxyether derivative,(N) a triazine derivative,(O) a copper-hydroxy quinoline complex,(P) an N-formul derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboxamide derivative.Type: GrantFiled: April 12, 1989Date of Patent: June 12, 1990Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
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Patent number: 4933337Abstract: A fungicidal composition comprising a fungicidally effective amount of (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in whichA is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,or an addition product thereof with an acid or metal salt, and (ii) at least one member selected from the group consisting of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a quanidine derivative,(D) an aromatic carboxylic acid derivative,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclene compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxy ether derivative,(N) a triazine derivative,(O) a copper complex salt,(P) an N-formyl derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboximide derivative.Type: GrantFiled: March 29, 1989Date of Patent: June 12, 1990Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
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Patent number: 4918093Abstract: Hydroxyethyl-azolyl oxime ethers of the formula ##STR1## in which R represents hydrogen, alkyl with 1 to 6 carbon atoms or alkenyl with 2 to 6 carbon atoms andR.sup.1 represents the radicals of the formula ##STR2## wherein R.sup.2 represents hydrogen, fluorine or chlorine,R.sup.3 represents hydrogen, fluorine or chlorine andX represents oxygen, sulphur or a CH.sub.2 group,and acid addition salts and metal salt complexes thereof. Such hydroxyethyl-azolyl oxime ethers are useful as fungicides.Type: GrantFiled: July 13, 1988Date of Patent: April 17, 1990Assignee: Bayer AktiengesellschaftInventors: Wolfgang Kramer, Karl H. Buchel, Graham Holmwood, Stefan Dutzmann, Paul Reinecke
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Patent number: 4911750Abstract: A plant growth-inhibiting composition comprising ##STR1## wherein the various radicals are as defined.Type: GrantFiled: February 8, 1984Date of Patent: March 27, 1990Assignee: Bayer AktiengesellschaftInventors: Klaus Lurssen, Graham Holmwood, Wolfgang Kramer, Erik Regel, Wolf Reiser, Rolf Schroder
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Patent number: 4911746Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3, a process for their preparation and their use as plant growth regulators and fungicides.Type: GrantFiled: May 8, 1985Date of Patent: March 27, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
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Patent number: 4904296Abstract: Compounds which are substituted 1-hydroxyalkylazolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group, Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.Type: GrantFiled: November 17, 1987Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes, Volker Paul
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Patent number: 4904298Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.Type: GrantFiled: June 5, 1987Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
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Patent number: 4904682Abstract: A method of combating mycoses in a patient in need thereof which comprises administering to such patient an antimycotically effective amount of a triazolylalkanol of the formula ##STR1## in which Ar stands for optionally substituted aryl andX stands for one of the groups --CH.sub.2 --; --O--CH.sub.2 --; --S--CH.sub.2 --; --CH.sub.2 --CH.sub.2 --; --CH.dbd.CH-- or --C.tbd.C--,or a physiologically tolerable acid addition salt thereof.Type: GrantFiled: October 19, 1988Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventors: Wolfgang Kramer, Graham Holmwood, Karl H. Buchel, Manfred Plempel
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Patent number: 4902703Abstract: A fungicidal composition comprising a fungicidally effective amount of(a) 3,3-dimethyl-2-(4-methoximinomethyl-phenoxymethyl)-1-(1,2,4-triazol-1-yl)- but an-2-ol of the formula ##STR1## and (b) N,N-dimethyl-N'-(fluorodichloromethylmercapto)-N'-(4-methyl-phenyl-sulpham ide of the formula ##STR2##Type: GrantFiled: January 6, 1988Date of Patent: February 20, 1990Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Helmut Kaspers, Hans Scheinpflug, Graham Holmwood
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Patent number: 4898875Abstract: Novel mercapto-substituted hydroxyethyl-(triazol-l-yl) derivatives of the formula ##STR1## in which Ar represents optionally substituted aryl,X represents oxygen, sulphur, a direct bond or the groupings --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --, --SCH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --, and --S--CH.sub.2 --CH.sub.2 --, the hetero atom being bonded to the aryl radical if X represents --OCH.sub.2 --, --SCH.sub.2 --, --O--CH.sub.2 --CH.sub.2 -- or --S--CH.sub.2 --CH.sub.2 -- andR represents hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl or optionally substituted phenyl, and their acid addition salts and metal salt complexes are very effective as fungicides and parasiticides.Type: GrantFiled: August 31, 1987Date of Patent: February 6, 1990Assignee: Bayer AktiengesellschaftInventors: Karl H. Buchel, Graham Holmwood, Udo Kraatz, Wolfgang Kramer, Paul Reinecke, Wilhelm Brandes, Wilhelm Stendel
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Patent number: 4897107Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.Type: GrantFiled: November 8, 1983Date of Patent: January 30, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
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Patent number: 4897410Abstract: Synergistic fungicidal compositions comprising(i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which R.sup.1, R.sup.2, X, Y and A have various meanings, or addition products thereof with acids or metal salts, and(ii) at least one of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a quanidine derivative,(D) an aromatic acid lactone,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S, N-heterocyclic compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxyether derivative,(N) a triazine derivative,(O) a copper-hydroxy quinoline complex,(P) an N-formula derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboxamide derivative.Type: GrantFiled: December 7, 1988Date of Patent: January 30, 1990Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
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Patent number: 4894383Abstract: Fungicidal hydroxyalkyl-triazolyl derivatives of the formula ##STR1## in which R represents a radical of the formula --CH.sub.2 --CH(CH.sub.3).sub.2, ##STR2## Z represents halogen, alkyl with 1 to 4 carbon atoms, halogenoalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio with 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl or alkoximinomethyl with 1 to 4 carbon atoms in the alkoxy group andm represents the numbers 0, 1, 2 or 3, and addition products thereof with acids and metal salts. Intermediates of the formulas ##STR3## are also new.Type: GrantFiled: May 5, 1988Date of Patent: January 16, 1990Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Udo Kraatz, Karl H. Buchel, Wilhelm Brandes, Stefan Dutzmann, Paul Reinecke
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Patent number: 4894382Abstract: The invention provides substituted 1,3-diazolyl-2-propanols defined herein generically by formula (I), useful as antimycotic agents. Also included in the invention are methods for the procurement of said substituted 1,3-diazolyl-2-propanols, compositions containing said antimycotic compounds and methods for the use of said compounds and compositions for treatment of mycoses.Type: GrantFiled: October 29, 1986Date of Patent: January 16, 1990Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Graham Holmwood, Erik Regel, Karl H. Buchel, Klaus Schaller, Manfred Plempel
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Patent number: 4871390Abstract: A 1-Hydroxyethyl-azole compound of the formula ##STR1## wherein R is an alkyl radical with 1 to 4 carbon atoms; a cycloalkyl radical which has 3 to 7 carbon atoms and is optionally substituted by alkyl with 1 or 2 carbon atoms or a phenyl radical which is optionally substituted by halogen, alkyl with 1 to 4 carbon atoms or haloalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms; or else is phenyl which is optionally mono- or di-substituted by identical or different substituents selected form fluorine, chlorine, methyl and trifluoromethylX is --CH--;Y is a grouping --OCH.sub.Type: GrantFiled: May 8, 1985Date of Patent: October 3, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
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Patent number: 4870092Abstract: A fungicidal composition comprising a fungicidally effective amount of a 1,3-diazolyl-2-propanol of the formula ##STR1## in which Alk.sup.1 is alkyl, andAlk.sup.2 is alkyl, orAlk.sup.1 and Alk.sup.2 together complete a cycloaliphatic ring,X is a nitrogen atom or the CH group,Y is a nitrogen atom or the CH group, andR is optionally substituted phenyl, phenylalkyl, phenoxy, phenylthio, phenoxyalkyl, phenylthioalkyl, benzyloxy or benzylthio,or a physiologically acceptable product thereof with an acid or metal salt in admixture with a diluent.Type: GrantFiled: February 8, 1984Date of Patent: September 26, 1989Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Graham Holmwood, Erick Regel, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes