Patents by Inventor Graham Holmwood

Graham Holmwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4960456
    Abstract: Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents a substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cyclo-alkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: October 2, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes, Volker Paul
  • Patent number: 4960453
    Abstract: Fungicidal and plant growth-regulating hydroxyalkylazolyl derivatives of the formula ##STR1## in which Z represents halogen, alkyl with 1 to 4 carbon atoms, halogenoalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio with 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl or alkoximinomethyl with 1 to 4 carbon atoms in the alkoxy group,X represents oxygen, sulphur or a CH.sub.2 group andm represents the number 0, 1, 2 or 3,and addition products thereof with acids and metal salts. Intermediates of the formulas ##STR2## are also new.
    Type: Grant
    Filed: May 5, 1988
    Date of Patent: October 2, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Gerhard Jager, Karl H. Buchel, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler
  • Patent number: 4960781
    Abstract: Fungicidal bisazolyl-hydroxyalkyl derivatives of the formula ##STR1## in which Ar stands for optionally substituted aryl,X stands for a grouping --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 -- or --SH.dbd.CH--,Y stands for a nitrogen atom or the grouping CR.sup.3,R.sup.1, R.sup.2 and R.sup.3 stand for hydrogen, halogen or methyl, andn stands for the numbers 0, 1 or 2,and acid addition salts and metal salt complexes thereof. Intermediates of the formulas ##STR2## are also new.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: October 2, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Wolfgang Kramer, Erik Regel, Hans L. Elbe, Karl H. Buchel, Stefan Dutzmann, Wilhelm Brandes, Paul Reinecke
  • Patent number: 4952595
    Abstract: Novel heterocyclic amide derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, or represents alkenyl which has more than 2 carbon atoms and is optionally substituted by halogen, or represents alkinyl which has more than 2 carbon atoms and is optionally substituted by halogen, or represents alkoxyalkyl or alkylthioalkyl;R.sup.2 represents optionally substituted naphtyl, or represents optionally substituted tetrahydronaphthyl, or represents optionally substituted indanyl;A represents an alkylene bridge, or also an alkenylene bridge if X denotes a direct bond;X represents oxygen, sulphur or a direct bond;Y represents oxygen or sulphur;B represents imidazol-1-yl, pyridin-3-yl, pyrazin-2-yl, pyrimidin-5-yl, 1,2,4-triazol-1-yl or 1-methyl-imidazol-5-yl;and their acid addition salts and metal salt complexes, are outstandingly active as fungicides.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: August 28, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Joachim Weissmuller, Wilhelm Brandes, Paul Reinecke
  • Patent number: 4933358
    Abstract: Synergistic fungicidal compositions comprising (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which R.sup.1, R.sup.2, X, Y and A have various meanings, or addition products thereof with acids or metal salts, and (ii) at least one of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a guanidine derivative,(D) an aromatic acid lactone,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclic compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxyether derivative,(N) a triazine derivative,(O) a copper-hydroxy quinoline complex,(P) an N-formul derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboxamide derivative.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: June 12, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
  • Patent number: 4933337
    Abstract: A fungicidal composition comprising a fungicidally effective amount of (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in whichA is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,or an addition product thereof with an acid or metal salt, and (ii) at least one member selected from the group consisting of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a quanidine derivative,(D) an aromatic carboxylic acid derivative,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclene compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxy ether derivative,(N) a triazine derivative,(O) a copper complex salt,(P) an N-formyl derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboximide derivative.
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: June 12, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
  • Patent number: 4918093
    Abstract: Hydroxyethyl-azolyl oxime ethers of the formula ##STR1## in which R represents hydrogen, alkyl with 1 to 6 carbon atoms or alkenyl with 2 to 6 carbon atoms andR.sup.1 represents the radicals of the formula ##STR2## wherein R.sup.2 represents hydrogen, fluorine or chlorine,R.sup.3 represents hydrogen, fluorine or chlorine andX represents oxygen, sulphur or a CH.sub.2 group,and acid addition salts and metal salt complexes thereof. Such hydroxyethyl-azolyl oxime ethers are useful as fungicides.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: April 17, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Graham Holmwood, Stefan Dutzmann, Paul Reinecke
  • Patent number: 4911750
    Abstract: A plant growth-inhibiting composition comprising ##STR1## wherein the various radicals are as defined.
    Type: Grant
    Filed: February 8, 1984
    Date of Patent: March 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Lurssen, Graham Holmwood, Wolfgang Kramer, Erik Regel, Wolf Reiser, Rolf Schroder
  • Patent number: 4911746
    Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3, a process for their preparation and their use as plant growth regulators and fungicides.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: March 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
  • Patent number: 4904296
    Abstract: Compounds which are substituted 1-hydroxyalkylazolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group, Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes, Volker Paul
  • Patent number: 4904298
    Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
  • Patent number: 4904682
    Abstract: A method of combating mycoses in a patient in need thereof which comprises administering to such patient an antimycotically effective amount of a triazolylalkanol of the formula ##STR1## in which Ar stands for optionally substituted aryl andX stands for one of the groups --CH.sub.2 --; --O--CH.sub.2 --; --S--CH.sub.2 --; --CH.sub.2 --CH.sub.2 --; --CH.dbd.CH-- or --C.tbd.C--,or a physiologically tolerable acid addition salt thereof.
    Type: Grant
    Filed: October 19, 1988
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Graham Holmwood, Karl H. Buchel, Manfred Plempel
  • Patent number: 4902703
    Abstract: A fungicidal composition comprising a fungicidally effective amount of(a) 3,3-dimethyl-2-(4-methoximinomethyl-phenoxymethyl)-1-(1,2,4-triazol-1-yl)- but an-2-ol of the formula ##STR1## and (b) N,N-dimethyl-N'-(fluorodichloromethylmercapto)-N'-(4-methyl-phenyl-sulpham ide of the formula ##STR2##
    Type: Grant
    Filed: January 6, 1988
    Date of Patent: February 20, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Brandes, Helmut Kaspers, Hans Scheinpflug, Graham Holmwood
  • Patent number: 4898875
    Abstract: Novel mercapto-substituted hydroxyethyl-(triazol-l-yl) derivatives of the formula ##STR1## in which Ar represents optionally substituted aryl,X represents oxygen, sulphur, a direct bond or the groupings --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --, --SCH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --, and --S--CH.sub.2 --CH.sub.2 --, the hetero atom being bonded to the aryl radical if X represents --OCH.sub.2 --, --SCH.sub.2 --, --O--CH.sub.2 --CH.sub.2 -- or --S--CH.sub.2 --CH.sub.2 -- andR represents hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl or optionally substituted phenyl, and their acid addition salts and metal salt complexes are very effective as fungicides and parasiticides.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: February 6, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl H. Buchel, Graham Holmwood, Udo Kraatz, Wolfgang Kramer, Paul Reinecke, Wilhelm Brandes, Wilhelm Stendel
  • Patent number: 4897107
    Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.
    Type: Grant
    Filed: November 8, 1983
    Date of Patent: January 30, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
  • Patent number: 4897410
    Abstract: Synergistic fungicidal compositions comprising(i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which R.sup.1, R.sup.2, X, Y and A have various meanings, or addition products thereof with acids or metal salts, and(ii) at least one of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a quanidine derivative,(D) an aromatic acid lactone,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S, N-heterocyclic compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxyether derivative,(N) a triazine derivative,(O) a copper-hydroxy quinoline complex,(P) an N-formula derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboxamide derivative.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: January 30, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
  • Patent number: 4894383
    Abstract: Fungicidal hydroxyalkyl-triazolyl derivatives of the formula ##STR1## in which R represents a radical of the formula --CH.sub.2 --CH(CH.sub.3).sub.2, ##STR2## Z represents halogen, alkyl with 1 to 4 carbon atoms, halogenoalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio with 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl or alkoximinomethyl with 1 to 4 carbon atoms in the alkoxy group andm represents the numbers 0, 1, 2 or 3, and addition products thereof with acids and metal salts. Intermediates of the formulas ##STR3## are also new.
    Type: Grant
    Filed: May 5, 1988
    Date of Patent: January 16, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Udo Kraatz, Karl H. Buchel, Wilhelm Brandes, Stefan Dutzmann, Paul Reinecke
  • Patent number: 4894382
    Abstract: The invention provides substituted 1,3-diazolyl-2-propanols defined herein generically by formula (I), useful as antimycotic agents. Also included in the invention are methods for the procurement of said substituted 1,3-diazolyl-2-propanols, compositions containing said antimycotic compounds and methods for the use of said compounds and compositions for treatment of mycoses.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: January 16, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Graham Holmwood, Erik Regel, Karl H. Buchel, Klaus Schaller, Manfred Plempel
  • Patent number: 4871390
    Abstract: A 1-Hydroxyethyl-azole compound of the formula ##STR1## wherein R is an alkyl radical with 1 to 4 carbon atoms; a cycloalkyl radical which has 3 to 7 carbon atoms and is optionally substituted by alkyl with 1 or 2 carbon atoms or a phenyl radical which is optionally substituted by halogen, alkyl with 1 to 4 carbon atoms or haloalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms; or else is phenyl which is optionally mono- or di-substituted by identical or different substituents selected form fluorine, chlorine, methyl and trifluoromethylX is --CH--;Y is a grouping --OCH.sub.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: October 3, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
  • Patent number: 4870092
    Abstract: A fungicidal composition comprising a fungicidally effective amount of a 1,3-diazolyl-2-propanol of the formula ##STR1## in which Alk.sup.1 is alkyl, andAlk.sup.2 is alkyl, orAlk.sup.1 and Alk.sup.2 together complete a cycloaliphatic ring,X is a nitrogen atom or the CH group,Y is a nitrogen atom or the CH group, andR is optionally substituted phenyl, phenylalkyl, phenoxy, phenylthio, phenoxyalkyl, phenylthioalkyl, benzyloxy or benzylthio,or a physiologically acceptable product thereof with an acid or metal salt in admixture with a diluent.
    Type: Grant
    Filed: February 8, 1984
    Date of Patent: September 26, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Graham Holmwood, Erick Regel, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes