Patents by Inventor Graham Holmwood
Graham Holmwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4870093Abstract: The invention relates to 1-hydroxylethyl-azole derivatives of formula (I) in composition form and includes the use of such compositions as antimicrobial agents.Type: GrantFiled: October 26, 1984Date of Patent: September 26, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Manfred Plempel, Ingo Haller
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Patent number: 4868196Abstract: Compounds which are ether derivatives of substituted 1-hydroxyalkyl-azoles, of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R.sup.1 represents a substituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl radical or, if either A represents a nitrogen atom, or if A represents the CH group and at the same B represents oxygen or sulphur, R.sup.1 also represents an unsubstituted alkyl radical,R.sup.Type: GrantFiled: May 2, 1986Date of Patent: September 19, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Paul-Ernst Frohberger, Wilhelm Brandes, Klaus Lurssen
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Patent number: 4855438Abstract: A new process for the preparation of an optically active 2-hydroxyethyl-azole derivative of the formula ##STR1##Type: GrantFiled: July 30, 1987Date of Patent: August 8, 1989Assignee: Bayer AktiengesellschaftInventors: Johannes Kaulen, Dieter Arlt, Graham Holmwood, Wolfgang Kramer
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Patent number: 4849440Abstract: Synergistic fundicidal compositions comprising (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which R.sup.1, R.sup.2, X, Y and A have various meanings, or addition products thereof with acids or metal salts, and (ii) at least one of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a quanidine derivative,(D) an aromatic acid lactone,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosporic acid ester,(I) a tetrahydroquinoline derivative,(J) an S, N-heterocyclic compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxyether derivative,(N) a triazine derivative,(O) a copper-hydroxy quinoline complex,(P) an N-formul derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboxamide derivative.Type: GrantFiled: February 29, 1988Date of Patent: July 18, 1989Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
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Patent number: 4845112Abstract: A fungicidal composition comprising a fungicidally effective amount of (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which A is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--, or an addition product thereof with an acid or metal salt, and (ii) at least one member selected from the group consisting of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a quanidine derivative,(D) an aromatic carboxylic acid derivative,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclene compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxy ether derivative,(N) a triazine derivative,(O) a copper complex salt,(P) an N-formyl derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboximide derivative.Type: GrantFiled: August 26, 1987Date of Patent: July 4, 1989Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
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Patent number: 4845111Abstract: A fungicidal composition comprising a fungicidally effective amount of (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which A is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--or an addition product thereof with an acid or metal salt, and (ii) at least one member selected from the group consisting of(A) wettable sulphur(B) a polyhalogenoalkylthio derivative,(C) a guanidine derivative,(D) an aromatic carboxylic acid derivative,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclene compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxy ether derivative,(N) a triazine derivative,(O) a copper complex salt,(P) an N-formyl derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboximide derivative.Type: GrantFiled: May 12, 1988Date of Patent: July 4, 1989Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
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Patent number: 4843088Abstract: Hydroxyethyl-azole derivatives of the formula ##STR1## in which R.sup.1 represents alkyl or the grouping Ar--Y--,Ar represents optionally substituted aryl,X represents a nitrogen atom or the CH group,Y represents a direct bond or the grouping --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--,Z represents oxygen or the NOR.sup.2 group andR.sup.2 represents hydrogen, alkyl, alkenyl, alkynyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl,or addition products thereof with acids or metal salts, which possess fungicidal activity.Type: GrantFiled: May 29, 1986Date of Patent: June 27, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Wolfgang Kramer, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes
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Patent number: 4843089Abstract: A method of combating mycoses which comprises administering to a patient an antimycotically effective amount of a hydroxyethyl-azole of the formula ##STR1## in which R.sup.1 represents alkyl or the grouping Ar--Y--,Ar represents optionally substituted aryl,Y represents a direct bond or the groupings --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --, --CH.dbd.CH-- or --C.dbd.C--,X represents a nitrogen atom or the CH group,Z represents oxygen or the NOR.sup.2 group andR.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl, or an acid addition salt thereof.Type: GrantFiled: May 29, 1987Date of Patent: June 27, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Wolfgang Kramer, Karl H. Buchel, Manfred Plempel
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Patent number: 4840961Abstract: Novel heterocyclic amide derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, or represents alkenyl which has more than 2 carbon atoms and is optionally substituted by halogen, or represents alkinyl which has more than 2 carbon atoms and is optionally substituted by halogen, or represents alkoxyalkyl or alkylthioalkyl;R.sup.2 represents optionally substituted naphthyl, or represents optionally substituted tetrahydronaphthyl, or represents optionally substituted indanyl;A represents an alkylene bridge, or also an alkenylene bridge if X denotes a direct bond;X represents oxygen, sulphur or a direct bond;Y represents oxygen or sulphur;B represents imidazol-1-yl, pyridin-3-yl, pyrazin-2-yl, pyrimidin-5-yl, 1,2,4-triazol-1-yl or 1-methyl-imidazol-5-yl-;and their acid addition salts and metal salt complexes, are outstandingly active as fungicides.Type: GrantFiled: April 11, 1986Date of Patent: June 20, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Joachim Weissmuller, Wilhelm Brandes, Paul Reinecke
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Patent number: 4831048Abstract: A fungicidal composition comprising a fungicidally effective amount of(a) 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-pentan-3-ol of the formula ##STR1## and (b) N,N-dimethyl-N'-(fluorodichloromethylmercapto)-N'-(4-methyl-phenyl)-sulpha mide of the formula ##STR2##Type: GrantFiled: January 6, 1988Date of Patent: May 16, 1989Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Helmut Kaspers, Hans Scheinpflug, Graham Holmwood
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Patent number: 4806644Abstract: A process for the preparation of a 5-acylpyrimidine of the formula ##STR1## in which R is an organic radical comprising reacting a methyl ketone of the formulaR--CO--Ch.sub.3in a first stage with a formylating reagent in the presence of a base to form an enolketone of the formulaR--CO--CH.dbd.CH--OR.sup.10in whichR.sup.10 represents hydrogen or a base radical, thereafter reacting the enolketone in 2nd and 3rd stages with formamidine or a formamidine salt, and with an amino-formylating agent, and, in a 4th stage heating to cyclize the compound formed.The end products, some of which are new, are intermediates for making herbicides.Type: GrantFiled: April 1, 1987Date of Patent: February 21, 1989Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Graham Holmwood
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Patent number: 4797499Abstract: Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.Type: GrantFiled: August 11, 1986Date of Patent: January 10, 1989Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes, Volker Paul
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Patent number: 4789672Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.Type: GrantFiled: May 8, 1985Date of Patent: December 6, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
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Patent number: 4783538Abstract: A process for the preparation of optically active azolylcarbinol derivatives having antimycotic fungicidal and plant growth regulating properties from racemic mixtures thereof. The (-)-enantiomer of 2-(4-chloro-phenoxymethyl)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol of the formula ##STR1## is prepared.Type: GrantFiled: October 25, 1985Date of Patent: November 8, 1988Assignee: Bayer AktiengesellschaftInventors: Udo Kraatz, Graham Holmwood, Dieter Berg, Manfred Plempel
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Patent number: 4744817Abstract: Novel triazole of the formula ##STR1## in which R represents alkyl, cycloalkyl or the groupings ##STR2## wherein X.sup.1 represents hydrogen or halogen,X.sup.2 represents halogen,Y represents alkoxy, alkylthio, halogenoalkoxy, halogenoalkylthio, alkenyl, alkoxycarbonyl, cyano, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylthio, optionally substituted phenylalkoxy or optionally substituted phenylalkylthio andn represents the number 0, 1 or 2,Z represents halogen, alkyl, halogenoalkyl, halogenoalkoxy, halogenoalkylthio or phenyl andm represents the number 0, 1, 2, or 3,or addition products thereof with acids and metal salts, which exhibit fungicidal and plant growth-regulating activity.Type: GrantFiled: March 3, 1986Date of Patent: May 17, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes, Gerd Hanssler
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Patent number: 4738962Abstract: Fungicidally active novel piperazinylmethyl-1,2,4-triazolylmethyl-carbinols of the formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkinyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aryloxyalkyl or optionally substituted arylthioalkyl,R.sup.1 represents hydrogen or alkyl,R.sup.2 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl,Z represents the ##STR2## group and p represents the number 0 or 1,or addition products thereof with acids and metal salts.Type: GrantFiled: February 21, 1986Date of Patent: April 19, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke
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Patent number: 4734126Abstract: Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.Type: GrantFiled: December 20, 1984Date of Patent: March 29, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Erik Regel, Gerhard Jager, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes, Volker Paul
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Patent number: 4723984Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, -- CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.Type: GrantFiled: June 18, 1984Date of Patent: February 9, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Klaus Lurssen, Paul-Ernst Frohberger, Wilhelm Brandes
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Patent number: 4713456Abstract: A process for the preparation of a 5-acylpyrimidine of the formula ##STR1## in which R is an organic radical comprising reacting a methyl ketone of the formulaR--CO--CH.sub.3in a first stage with a formylating reagent in the presence of a base to form an enolketone of the formulaR--CO--CH.dbd.CH--OR.sup.10in which R.sup.10 represents hydrogen or a base radical, thereafter reacting the enolketone in 2nd and 3rd stages with formamidine or a formamidine salt, and with an amino-formylating agent, and, in a 4th stage heating to cyclize the compound formed.The end products, some of which are new, are intermediates for making herbicides.Type: GrantFiled: August 26, 1985Date of Patent: December 15, 1987Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Graham Holmwood
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Patent number: RE32796Abstract: A benzyl-pyrimidinylalkyl-ether of the formula ##STR1## in which R is alkyl, optionally substituted cycloalkyl or optionally substituted phenyl, andX.sup.1, X.sup.2 and X.sup.3 each independently is hydrogen, halogen, alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, cyano, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy,or an acid addition salt or metal salt complex thereof, which possesses fungicidal and plant growth-regulating properties. The corresponding pyrimidinyl-carbinols are also new.Type: GrantFiled: August 1, 1984Date of Patent: December 6, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Klaus Lurssen, Paul-Ernst Frohberger