Patents by Inventor Gregory M. Lanza

Gregory M. Lanza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BLOOD SUBSTITUTE COMPOSITION AND METHOD OF USE
    Publication number: 20160051635
    Abstract: The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.
    Type: Application
    Filed: November 2, 2015
    Publication date: February 25, 2016
    Inventors: Gregory M. Lanza, Dipanjan Pan, Allan Doctor, Philip C. Spinella
  • METHODS FOR IMPROVING MUSCLE STRENGTH
    Publication number: 20150335623
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Application
    Filed: August 3, 2015
    Publication date: November 26, 2015
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Methods for improving muscle strength
    Patent number: 9095521
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: August 4, 2015
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • HOMING AGENTS
    Publication number: 20150023872
    Abstract: The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest, such as a biomarker of a disease or disorder.
    Type: Application
    Filed: May 5, 2014
    Publication date: January 22, 2015
    Inventors: Gregory M. Lanza, Samuel A. Achilefu, Grace Hu
  • METHODS FOR IMPROVING MUSCLE STRENGTH
    Publication number: 20150011578
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 8, 2015
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Universal anchor peptide for nanoparticles
    Patent number: 8617516
    Abstract: The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: December 31, 2013
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Hua Pan, Neelesh R. Soman, Gregory M. Lanza, Paul H. Schlesinger
  • PRODRUG COMPOSITIONS, PRODRUG NANOPARTICLES, AND METHODS OF USE THEREOF
    Publication number: 20130122100
    Abstract: Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents.
    Type: Application
    Filed: April 15, 2011
    Publication date: May 16, 2013
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Gregory M. Lanza, Dipanjan Pan
  • Targeted MR imaging agents
    Patent number: 8003078
    Abstract: MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: August 23, 2011
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Garry E. Kiefer, Phillip S. Athey
  • UNIVERSAL ANCHOR PEPTIDE FOR NANOPARTICLES
    Publication number: 20110123438
    Abstract: The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.
    Type: Application
    Filed: October 22, 2010
    Publication date: May 26, 2011
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Samuel A. Wickline, Hua Pan, Neelesh R. Soman, Gregory M. Lanza, Paul H. Schlesinger
  • TARGETED ATHEROSCLEROSIS TREATMENT
    Publication number: 20110014124
    Abstract: This invention relates generally to methods for ameliorating at least one symptom or aspect of atherosclerosis. The methods include administration of targeted carrier compositions comprising a therapeutic agent effective in ameliorating at least one aspect of atherosclerosis coupled to a targeting ligand effective is targeting the therapeutic agent to tissue associated with atherosclerotic plaque.
    Type: Application
    Filed: September 24, 2010
    Publication date: January 20, 2011
    Inventors: Gregory M. LANZA, Samuel A. WICKLINE
  • PARTICLES FOR IMAGING
    Publication number: 20100297019
    Abstract: The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.
    Type: Application
    Filed: October 9, 2008
    Publication date: November 25, 2010
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Dipanjan Pan, Angana Senpan
  • LIGAND DIRECTED TOROIDAL NANOPARTICLES FOR THERAPY AND DIAGNOSTIC IMAGING
    Publication number: 20100297007
    Abstract: The present invention provides nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to deliver therapeutic agents and/or imaging agents.
    Type: Application
    Filed: October 9, 2008
    Publication date: November 25, 2010
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Dipanjan Pan
  • Targeted atherosclerosis treatment
    Patent number: 7803374
    Abstract: This invention relates generally to methods for ameliorating at least one symptom or aspect of atherosclerosis. The methods include administration of targeted carrier compositions comprising a therapeutic agent effective in ameliorating at least one aspect of atherosclerosis coupled to a targeting ligand effective is targeting the therapeutic agent to tissue associated with atherosclerotic plaque.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: September 28, 2010
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Chelating agents with lipophilic carriers
    Patent number: 7727512
    Abstract: Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: June 1, 2010
    Assignees: Barnes-Jewish Hospital, The Dow Chemical Company
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Phillip S. Athey, Gyongyi Gulyas, Garry E. Kiefer
  • CELL LABELING WITH PERFLUOROCARBON NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
    Publication number: 20090263329
    Abstract: Methods of obtaining cells internally labeled with perfluorocarbon nanoparticles suitable for magnetic resonance imaging and spectroscopy are disclosed. Also disclosed are methods for obtaining magnetic resonance imaging data from labeled under clinically relevant scan times and field strengths. Finally, the application further discloses methods of specifically detecting and distinguishing magnetic resonance imaging and spectroscopy data from two distinct sets of cells labeled with distinct types of perfluorocarbon nanoparticles.
    Type: Application
    Filed: February 23, 2007
    Publication date: October 22, 2009
    Applicant: Washington University
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Integrin targeted imaging agents
    Patent number: 7566442
    Abstract: Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for ?v?3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: July 28, 2009
    Assignees: Barnes-Jewish Hospital, Bristol Myers Squibb Medical Imaging, Inc.
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Tom Harris
  • METHODS OF IMAGING EMPLOYING CHELATING AGENTS
    Publication number: 20080241061
    Abstract: Methods to image neovasculature associated with tumors using emulsions of targeted lipid/surfactant coated nanoparticles coupled to chelating agents containing radioisotopes are described.
    Type: Application
    Filed: November 21, 2007
    Publication date: October 2, 2008
    Inventors: Gregory M. LANZA, Samuel A. Wickline
  • Efficacy and Safety of Targeted Particulate Agents with Decoy Systems
    Publication number: 20080193372
    Abstract: A decoy inactive carrier composition is administered simultaneously with a targeted composition containing vehicles for delivering a desired agent to a biological target. This simultaneous administration enhances the delivery of the targeted composition to the desired location in a subject.
    Type: Application
    Filed: February 10, 2005
    Publication date: August 14, 2008
    Applicant: BARNES-JEWISH HOSPITAL
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • INTEGRIN TARGETED IMAGING AGENTS
    Publication number: 20080175792
    Abstract: Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for ?v?3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
    Type: Application
    Filed: January 9, 2008
    Publication date: July 24, 2008
    Applicants: Barnes-Jewish Hospital, Bristol Myers Squibb Medical Imaging, Inc.
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Tom Harris
  • CHELATING AGENTS WITH LIPOPHILIC CARRIERS
    Publication number: 20080145311
    Abstract: Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
    Type: Application
    Filed: October 9, 2007
    Publication date: June 19, 2008
    Inventors: Gregory M. LANZA, Samuel A. Wickline, Phillip S. Athey, Gyongyi Gulyas, Garry E. Kiefer