Patents by Inventor Gregory M. Lanza

Gregory M. Lanza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acoustically reflective liposomes and methods to make and use the same
    Patent number: 5858399
    Abstract: This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: January 12, 1999
    Assignee: Northwestern University
    Inventors: Gregory M. Lanza, M. Hayat Alkan-Onyuksel, Melvin E. Klegerman, David D. McPherson, Bonnie J. Kane, Sasha E. Murer
  • Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
    Patent number: 5780010
    Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: July 14, 1998
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Avidin-biotin conjugated emulsions as a site specific binding system
    Patent number: 5690907
    Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
    Type: Grant
    Filed: June 8, 1995
    Date of Patent: November 25, 1997
    Assignee: The Jewish Hospital of St. Louis
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Acoustically reflective liposomes and methods to make and use same
    Patent number: 5612057
    Abstract: This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: March 18, 1997
    Assignee: Northwestern University
    Inventors: Gregory M. Lanza, M. Hayat Onyuksel, Melvin E. Klegerman, Michael J. Vonesh, David L. McPherson
  • Composition and method for improving feed utilization or tissue production in animals
    Patent number: 4618604
    Abstract: A composition and method for improving feed utilization or tissue production in animals are disclosed. At least one substituted phenylphosphinic acid derivative or pharmaceutically acceptable salts thereof is administered as a feed supplement at a daily dosage between about 0.005 and 350 mg/animal. The specific daily dosage depends on the specie, weight of the animal and the desired production trait to be improved.
    Type: Grant
    Filed: June 14, 1984
    Date of Patent: October 21, 1986
    Assignee: Monsanto Company
    Inventors: Melvin J. DeGeeter, Gregory M. Lanza, Billy D. Vineyard