Abstract: Techniques for determining predictions on a top-down representation of an environment based on vehicle action(s) are discussed herein. Sensors of a first vehicle (such as an autonomous vehicle) can capture sensor data of an environment, which may include object(s) separate from the first vehicle (e.g., a vehicle or a pedestrian). A multi-channel image representing a top-down view of the object(s) and the environment can be generated based on the sensor data, map data, and/or action data. Environmental data (object extents, velocities, lane positions, crosswalks, etc.) can be encoded in the image. Action data can represent a target lane, trajectory, etc. of the first vehicle. Multiple images can be generated representing the environment over time and input into a prediction system configured to output prediction probabilities associated with possible locations of the object(s) in the future, which may be based on the actions of the autonomous vehicle.

Abstract: A method of assessing the impact of a certain treatment strategy for a patient on a digital twin or virtual model of that patient. It is recognized that the impact on a virtual twin could determine whether or not a treatment strategy is selected, as clinicians are becoming increasingly reliant on virtual twins to perform long-term monitoring of a patient's condition.

Abstract: Techniques for determining predictions on a top-down representation of an environment based on object movement are discussed herein. Sensors of a first vehicle (such as an autonomous vehicle) may capture sensor data of an environment, which may include object(s) separate from the first vehicle (e.g., a vehicle, a pedestrian, a bicycle). A multi-channel image representing a top-down view of the object(s) and the environment may be generated based in part on the sensor data. Environmental data (object extents, velocities, lane positions, crosswalks, etc.) may also be encoded in the image. Multiple images may be generated representing the environment over time and input into a prediction system configured to output a trajectory template (e.g., general intent for future movement) and a predicted trajectory (e.g., more accurate predicted movement) associated with each object. The prediction system may include a machine learned model configured to output the trajectory template(s) and the predicted trajector(ies).

Abstract: Techniques for determining predictions on a top-down representation of an environment based on vehicle action(s) are discussed herein. Sensors of a first vehicle (such as an autonomous vehicle) can capture sensor data of an environment, which may include object(s) separate from the first vehicle (e.g., a vehicle or a pedestrian). A multi-channel image representing a top-down view of the object(s) and the environment can be generated based on the sensor data, map data, and/or action data. Environmental data (object extents, velocities, lane positions, crosswalks, etc.) can be encoded in the image. Action data can represent a target lane, trajectory, etc. of the first vehicle. Multiple images can be generated representing the environment over time and input into a prediction system configured to output prediction probabilities associated with possible locations of the object(s) in the future, which may be based on the actions of the autonomous vehicle.

Abstract: The present disclosure relates to a system for patient-specific intervention planning, the system comprising a physical model of an anatomical structure, wherein the physical model is a patient-specific model based on medical image data; a virtual model of the anatomical structure, wherein the virtual model is a patient-specific model based on medical image data; a tracking device configured to track a position of a physical representation of an interventional tool with respect to the physical model of the anatomical structure; a processor configured to perform the step of: registering the physical model of the anatomical structure with the virtual model of the anatomical structure and registering the physical representation of the interventional tool with a virtual representation of the interventional tool based on the position of the physical representation of the interventional tool and the physical model of the anatomical structure.

Abstract: Techniques for determining predictions on a top-down representation of an environment based on vehicle action(s) are discussed herein. Sensors of a first vehicle (such as an autonomous vehicle) can capture sensor data of an environment, which may include object(s) separate from the first vehicle (e.g., a vehicle or a pedestrian). A multi-channel image representing a top-down view of the object(s) and the environment can be generated based on the sensor data, map data, and/or action data. Environmental data (object extents, velocities, lane positions, crosswalks, etc.) can be encoded in the image. Action data can represent a target lane, trajectory, etc. of the first vehicle. Multiple images can be generated representing the environment over time and input into a prediction system configured to output prediction probabilities associated with possible locations of the object(s) in the future, which may be based on the actions of the autonomous vehicle.

Abstract: The present disclosure relates generally to protective devices and cover members. In some embodiments, cover members are provided that are operable to protect covered components and to allow heat dissipation from the components. Cover members of the present disclosure are suitable for use with heat exchangers including, for example, those provided with hot water pressure washers.

Abstract: Techniques are disclosed for re-executing a data processing pipeline following a failure of at least one of its components. The techniques may include a syntax for defining a compute graph associated with the data processing pipeline and receiving such a compute graph in association with a specific data processing pipeline. The technique may include executing the data processing pipeline, determining that a component of the data processing pipeline failed, and determining a portion of the data processing pipeline to execute/re-execute based at least in part on dependencies defined by the data processing pipeline in association with the failed component. Re-executing the one or more components may comprise retrieving an output saved in association with a component upon which the failed component depends.

Abstract: The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral, bacterial or fungal infection, atherosclerosis, Type 1 or 2 diabetes, obesity, inflammatory disease, and/or SYK-associated disorder including by modulating biological processes through the inhibition of SYK alone, or in combination with inhibition of one or more of PI3 kinase including PI3K-gamma isoform, BET bromodomain proteins, CDK 4/6, and checkpoint proteins, comprising the administration of a compound(s) of Formula I-V (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: The present invention relates to a device for predicting an unfolded state of a foldable implant in biological tissue, the device comprising: a receiving unit configured to receive pre -treatment 3D planning image data and treatment image data, the treatment image data comprising catheter image data, the catheter image data comprising landmark image data; a segmentation module configured to segment the pre-treatment 3D planning image data resulting in segmented 3D planning image data; a search unit configured to locate the landmark image data within the treatment image data resulting in a known landmark position and a known landmark orientation; a registration module configured to register the segmented 3D planning image data to the treatment image data resulting in registered treatment image data; and a simulation unit configured to simulate an unfolded state of a foldable implant in biological tissue based on the known landmark position and the known landmark orientation in the biological tissue resulting i

Abstract: A computer system is disclosed comprising a processor arrangement communicatively coupled to a data storage arrangement storing a digital model of a section of a lumen system of a patient; and a communication module communicatively coupled to said processor arrangement and arranged to receive sensor data pertaining to an internal parameter of said lumen system from a sensor within said section of the lumen system. The processor arrangement is arranged to receive said sensor data from the communication module; retrieve said digital model from the data storage arrangement; simulate an actual physical condition of said lumen system by developing said digital model based on the received sensor data; and generate an output relating to said simulated actual physical condition for updating an electronic device. Also disclosed is a method of monitoring a patient with such a computer system, a computer program product for implementing such a method and a patient monitoring system.

Abstract: The invention relates to compounds and methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infaction, atheroscleosis. Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder including by modulating biological processes by the inhibition of cell cycle checkpoint targets CDKs, and/or PI3 kinase, and/or bromodomain protein binding to substrates, comprising the administration of a compound(s) of Formula 1-VI (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which provides a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium to a value between 15% by weight and 50% by weight.

Abstract: The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infaction, atheroscleosis, Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder including by modulating biological processes by the inhibition of PI3 kinase and/or bromodomain protein binding to substrates comprising the administration of a compound(s) of Formula I-IX (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which provides a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium to a value between 15% by weight and 60% by weight.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which includes a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium so that a second lubrication oil enriched operating medium is provided by the oil separator, the provided second operating medium having at least in a second operating state a viscosity ratio of ?>1.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which provides a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium to a value between 25% by weight and 80% by weight.

Abstract: The invention relates to compounds of Formulas I-VII (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating cellular signaling pathways and biological processes associated therewith including inhibition of kinase activity such as PI-3 kinase or inhibition of bromodomain proteins or both at the same time as well as to therapeutic methods for treating a disease associated with aberrant PI3K and/or bromodomain proteins.

Abstract: The invention relates to a navigation assistance system for assisting in navigating an interventional instrument (10) within a subject during an interventional procedure. Based on a provided current position and shape of the interventional instrument, a provided target position defining the position of a target (45) to which the interventional instrument is to be moved and provided configuration information being indicative of possible configurations of the interventional instrument a possible path (50) is determined, which allows the interventional instrument to reach the target. The determined possible path and preferentially also the current position and shape of the interventional instrument and the target position can be shown on a display in realtime, while a physician moves the interventional instrument, thereby assisting the physician in navigating the interventional instrument.

Abstract: The success of the positioning of devices for deployment inside an aneurysm, for example, is reliant on processes, which take place within an intervention procedure. For example, the position, orientation, or trajectory of the intervention device can affect the final position of a device for deployment deployed on the intervention device. Therefore, it is useful to predict the deployment position of a device for deployment based on a current localization of only the intervention device within an object of interest.