Abstract: The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including inhibition of kinase activity such as PI-3 kinase.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which provides a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium to a value between 15% by weight and 60% by weight.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which provides a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium to a value between 15% by weight and 50% by weight.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which includes a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium so that a second lubrication oil enriched operating medium is provided by the oil separator, the provided second operating medium having at least in a second operating state a viscosity ratio of K>1.

Abstract: A cooling system includes a refrigerant compressor and a first operating medium, which provides a mixture of refrigerant and lubrication oil. An oil separator reduces the percentage of the refrigerant in the operating medium to a value between 25% by weight and 80% by weight.

Abstract: A computing device executes one or more trusted execution environment (TEE) processes in a TEE of a processor. The one or more TEE processes cryptographically protect a secret and a policy. The policy specifies a plurality of conditions on usage of the secret. A particular non-TEE process generates a request whose fulfillment involves an action requiring use of the secret. Responsive to the request, one or more non-TEE processes determine whether a first subset of the plurality of conditions is satisfied. Responsive to the first subset of the plurality of conditions being satisfied, the one or more TEE processes determine that a second, different subset of the plurality of conditions is satisfied. Responsive to determining the second subset of the plurality of conditions is satisfied, the one or more TEE processes use the secret to perform the action.

Abstract: A computing device executes one or more trusted execution environment (TEE) processes in a TEE of a processor. The one or more TEE processes cryptographically protect a secret and a policy. The policy specifies a plurality of conditions on usage of the secret. A particular non-TEE process generates a request whose fulfillment involves an action requiring use of the secret. Responsive to the request, one or more non-TEE processes determine whether a first subset of the plurality of conditions is satisfied. Responsive to the first subset of the plurality of conditions being satisfied, the one or more TEE processes determine that a second, different subset of the plurality of conditions is satisfied. Responsive to determining the second subset of the plurality of conditions is satisfied, the one or more TEE processes use the secret to perform the action.

Abstract: The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infaction, atheroscleosis, Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder including by modulating biological processes by the inhibition of PI3 kinase and/or bromodomain protein binding to substrates comprising the administration of a compound(s) of Formula I-IX (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: A bearing comprising a plurality of rolling elements arranged between an inner and outer raceway thereof. A rolling contact interface is between a first rolling contact surface on at least one rolling element and a second rolling contact surface formed by one of the inner and outer raceways. The first rolling contact surface has a first RMS roughness Rq1 and a first roughness pattern ?1, expressed in terms of the Peklenik number ?. The second rolling contact surface has a second RMS roughness Rq2 and a second roughness pattern ?2. To minimize micropitting in the bearing, the rolling contact interface has a surface topography wherein (a) the roughness pattern of the first and second rolling contact surfaces are oriented in the direction of rolling, whereby ?1?3.0 and ?2?10.0; and (b) the first and of the second rolling contact surfaces have substantially equal roughness heights, whereby 0.8?Rq1/Rq2?1.25.

Abstract: The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atheroscleosis, Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder including by modulating biological processes by the inhibition of PI3 kinase and/or bromodomain protein binding to substrates comprising the administration of a compound(s) of Formula I-IX (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including inhibition of kinase activity such as PI-3 kinase.

Abstract: The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including inhibition of kinase activity such as PI-3 kinase.

Abstract: A computing device executes one or more trusted execution environment (TEE) processes in a TEE of a processor. The one or more TEE processes cryptographically protect a secret and a policy. The policy specifies a plurality of conditions on usage of the secret. A particular non-TEE process generates a request whose fulfillment involves an action requiring use of the secret. Responsive to the request, one or more non-TEE processes determine whether a first subset of the plurality of conditions is satisfied. Responsive to the first subset of the plurality of conditions being satisfied, the one or more TEE processes determine that a second, different subset of the plurality of conditions is satisfied. Responsive to determining the second subset of the plurality of conditions is satisfied, the one or more TEE processes use the secret to perform the action.

Abstract: The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infaction, atheroscleosis, Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder including by modulating biological processes by the inhibition of PI3 kinase and/or bromodomain protein binding to substrates composing the administration of a compound(s) of Formula I-IX (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: The success of the positioning of devices for deployment inside an aneurysm, for example, is reliant on processes,which take place within an intervention procedure. For example, the position, orientation, or trajectory of the intervention device can affect the final position of a device for deployment deployed on the intervention device. Therefore, it is useful to predict the deployment position of a device for deployment based on a current localization of only the intervention device within an object of interest.

Abstract: A bearing comprising a plurality of rolling elements arranged between an inner and outer raceway thereof. A rolling contact interface is between a first rolling contact surface on at least one rolling element and a second rolling contact surface formed by one of the inner and outer raceways. The first rolling contact surface has a first RMS roughness Rq1 and a first roughness pattern ?1, expressed in terms of the Peklenik number ?. The second rolling contact surface has a second RMS roughness Rq2 and a second roughness pattern ?2. To minimise micropitting in the bearing, the rolling contact interface has a surface topography wherein (a) the roughness pattern of the first and second rolling contact surfaces are oriented in the direction of rolling, whereby ?1?3.0 and ?2?10.0; and (b) the first and of the second rolling contact surfaces have substantially equal roughness heights, whereby 0.8?Rq1/Rq2?1.25.

Abstract: The invention relates to methods of treating diseases including but not limited to, cancer non-cancer proliferative disease, sepsis, autoimmune disease, viral infaction, atheroscleosis, Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder including by modulating biological processes by the inhibition of PI3 kinase and/or bromodomain protein binding to substrates composing the administration of a compound(s) of Formula I-IX (or pharmaceutically acceptable salts thereof) as defined herein.

Abstract: The invention relates to compounds of Formulas I-VII (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating cellular signaling pathways and biological processes associated therewith including inhibition of kinase activity such as PI-3 kinase or inhibition of bromodomain proteins or both at the same time as well as to therapeutic methods for treating a disease associated with aberrant PI3K and/or bromodomain proteins.

Abstract: A device and method of use for a towed portable cleaning facility is disclosed. The device employs storage tanks for both the storage and transport of cleaning fluids. The tanks serve the additional function of surrounding and enclosing the cleaning area an area that may be used for cleaning or storage. By utilizing the tanks as walls, the present invention provides a portable cleaning station. The device may further include the ability to treat and clean used fluids in order to either reuse or safely dispose of the used fluids as well as the ability to recover heat energy from an engine compartment to heat cleaning fluids.