Abstract: A purification device is provided. The purification device includes: an injection channel having an inlet provided on one end thereof; a purification channel and a discharge channel which branch off from the other end of the injection channel via a mesh part, and the remaining substance to be purified is discharged through the discharge channel; an ion-selective membrane contacting at least one side of the mesh part; and a buffer part arranged on the other side of the ion-selective membrane which is in contact with the mesh part, wherein the mesh part has an ion-selective coating layer formed on the surface thereof, and when an electric field is applied, an ion concentration polarization phenomenon occurs to the other end of the injection channel and to the adjacent portion of the mesh part, whereby an ion depletion zone is formed.

Abstract: A purification device is provided. The purification device includes: an injection channel having an inlet provided on one end thereof; a purification channel and a discharge channel which branch off from the other end of the injection channel via a mesh part, and the remaining substance to be purified is discharged through the discharge channel; an ion-selective membrane contacting at least one side of the mesh part; and a buffer part arranged on the other side of the ion-selective membrane which is in contact with the mesh part, wherein the mesh part has an ion-selective coating layer formed on the surface thereof, and when an electric field is applied, an ion concentration polarization phenomenon occurs to the other end of the injection channel and to the adjacent portion of the mesh part, whereby an ion depletion zone is formed.

Abstract: Disclosed is a skin-on-a-chip, which more closely resembles real skin by simulating the repetition of contraction and relaxation due to stretching of skin cells, by embedding a permanent magnet in the skin-on-a-chip. The skin-on-a-chip includes a connector that causes a linear motion in the skin cells of the chip when driven by a linear drive device outside the chip, which provides forward and backward movement, to thereby simulate contraction and relaxation of skin.

Abstract: The present invention relates to a small urea sensor module, configured such that a urease-immobilized insoluble porous support, in which urease is immobilized on a porous support made of a natural polymer such as silk fibroin, etc. or a synthetic polymer, is mounted in a fluidic chamber and also such that the electrode surface of a three-electrode strip is exposed to the bottom surface of the chamber. This urea sensor is essential for the evaluation of the regenerated solution from a portable peritoneal dialysis fluid regeneration system and has advantages such as portability, reproducibility, mass productivity and simplicity, which will greatly contribute to disease management of patients with chronic renal disease.

Abstract: Provided is a portable urea sensor which can be used under a flow condition by using a porous polytetrafluoroethylene (PTFE) membrane coated with parylene-A, which is parylene functionalized with an amine by vacuum deposition. To produce a specific electrochemical sensor signal from urea, urease, which is an enzyme hydrolyzing urea, is immobilized to a parylene-A-coated PTFE membrane by chemical crosslinking using glutaraldehyde. The urea-immobilized membranes are assembled in a polydimethylsiloxane (PDMS) fluid chamber, and a screen-printed carbon 3-electrode system is used. The success of the urease immobilization process is confirmed using scanning electronmicroscopy (SEM) and Fourier-transform infrared (FTIR) spectroscopy. The optimal concentration of urease to be immobilized to the parylene-A-coated PTFE membrane is determined to be 48 mg/mL, and the optimal number of the membranes in the PDMS chamber is determined to be 8.

Abstract: Provided is a microanalysis method and system using a Field Effect Transistor (FET). The microanalysis method includes a channel region having a receptor molecule fixed; forming a nano-particle conjugate in the channel region by supplying a sample for test and the nano-particle conjugate to the FET; growing a probe material on the channel region; and measuring a current flowing through the channel region, wherein the receptor molecule is a material that is selectively bonded to a target molecule in the sample for test.

Abstract: Provided is a microanalysis method and system using a Field Effect Transistor (FET). The microanalysis method includes a channel region having a receptor molecule fixed; forming a nano-particle conjugate in the channel region by supplying a sample for test and the nano-particle conjugate to the FET; growing a probe material on the channel region; and measuring a current flowing through the channel region, wherein the receptor molecule is a material that is selectively bonded to a target molecule in the sample for test.

Abstract: Provided are a device for storing a reagent capable of being adhered to a biochip and supplying the stored reagent to the biochip, and a method of discharging a reagent thereof. The device for storing a reagent includes an elastic film pressurizing part configured to pressurize an elastic film by magnetic force, and a reagent discharging part configured to store the reagent and discharge the reagent through an outlet by using the deformation in the elastic film due to the pressurization. According to the present invention, a magnetic force controlling device can be small-sized and the reagent can be automatically, high-precisely, and reproducibly supplied through the magnetic force control.

Abstract: Disclosed are a method and an apparatus for filtering plasma using magnetic force. The apparatus for filtering plasma using magnetic force includes: an inlet into which blood is injected; a filter unit filtering plasma in the blood passing through the inlet by capillary force; a magnetic force receiving part made of magnetizable materials and assisting plasma filtering by applying pressure to the filter unit by movement due to magnetic force generated from the outside; an outlet discharging plasma filtered from blood; and a filter outer body surrounding the inlet, the filter unit, the magnetic receiving part, and the outlet.

Abstract: A bio cartridge includes a reaction chamber disposed within a housing and containing a reagent, a specimen transfer channel providing a transfer path through which a specimen supplied to the housing is transferred into the reaction chamber, a mixing unit mixing the specimen with the reagent, and an air pressure unit providing air pressure to the specimen.

Abstract: Provided are a method and apparatus for measuring an isoelectric point using a field effect transistor. The method includes providing a field effect transistor including a substrate, source and drain electrodes disposed on the substrate and spaced apart from each other, and a channel region between the source and drain electrodes, providing a first electrolyte solution having a first concentration to the channel region of the field effect transistor and measuring a first current value of the channel region between the source and drain electrodes, providing a second electrolyte solution having a second concentration greater than the first concentration and measuring a second current value of the channel region between the source and drain electrodes, and determining the isoelectric point of the field effect transistor or a material disposed on the field effect transistor using a difference between the first and second current values.

Abstract: Provided is a biosensor chip. The biosensor chip includes a plurality of biosensor cells that are arranged in a matrix and selectively generate and output a sensed signal by addressing of external light, at least one sensing line that is simultaneously connected with the plurality of biosensor cells and transmits the sensed signal from one selected from the biosensor cells, and an output terminal that receives the sensed signal from the sensing line and outputs the sensed signal to an external reader. Thus, the biosensor cells are set in array in the biosensor chip without a separate driving unit, so that a process of manufacturing the biosensor chip is simplified. The biosensor cell to be sensed is selectively addressed through the external light, so that it is possible to reduce a price of the biosensor chip used as a disposable chip.

Abstract: Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the substrate, a microfluid supplier selectively supplying one of a reference buffer solution of low ionic concentration and a reaction solution of high ionic concentration containing target molecules, to the channel region of the FET to which the probe molecules are fixed, and a biomolecule detector detecting the target molecules by measuring a first current value of the channel region of the FET, and a second current value of the channel region of the FET to which the target molecules and the probe molecules that bind to each other in the reaction solution of high ionic concentration are fixed.

Abstract: There is provided an apparatus for irradiating a beam at a user's eye gaze point and an operation method thereof. The apparatus includes an eye gaze point detecting part analyzing a movement of a user's pupils and detecting the user's eye gaze point, and a beam irradiation part irradiating a beam at the user's eye gaze point detected by the eye gaze point detecting part. The apparatus detects the user's current eye gaze point and irradiates the beam at the user's detected eye gaze point, thereby allowing for the performance of desired control with greater accuracy.

Abstract: Provided is a microfluidic injection device and a method for injecting microfluidic. The microfluidic injection device includes a fluid injection chamber, a gas generation chamber applying pressure to the fluid injection chamber, and a channel connecting the fluid injection chamber to the gas generation chamber.

Abstract: Provided are a device for storing a reagent capable of being adhered to a biochip and supplying the stored reagent to the biochip, and a method of discharging a reagent thereof. The device for storing a reagent includes an elastic film pressurizing part configured to pressurize an elastic film by magnetic force, and a reagent discharging part configured to store the reagent and discharge the reagent through an outlet by using the deformation in the elastic film due to the pressurization. According to the present invention, a magnetic force controlling device can be small-sized and the reagent can be automatically, high-precisely, and reproducibly supplied through the magnetic force control.

Abstract: Provided is a blood pre-treating apparatus including an injecting part for injecting a blood sample, an albumin-removing part including albumin adsorption beads for removing albumins from the blood sample, and an agglutination part including an agglutination reactant, by which blood corpuscles in the blood sample may be agglutinated to form a hemagglutination reactant.

Abstract: Provided are a biosensor, an apparatus and a method for detecting a biomolecule using the biosensor. The biosensor may include a supporting substrate, a semiconductor layer spaced apart from a top surface of the supporting substrate by supporting patterns, and a nano-motor array formed on a top surface of the semiconductor layer. The nano-motor array may include a plurality of nano-metal rods configured to exhibit an autonomous propulsion in a fluid.

Abstract: Provided is a sensing device, which includes a reactive material layer (260) responding to a specific functional group in a fluid, a sensing capacitor (B) including first and second electrodes disposed on and under an insulating layer (230), the first electrode being disposed under the reactive material layer (260), and a field effect transistor including a gate electrode connected with the first electrode of the sensing capacitor. Here, the reactive material layer (260) is formed in a conductive three-dimensional structure to widen a surface area. Thus, the sensing device may have high sensitivity by maximizing a capacitor sharing effect and a change in voltage amount applied to a gate, which may be caused by widening a surface area of the conductive three-dimensional structure with respect to the fluid flow.

Abstract: Provided are an optical cavity enhanced turbidimeter and a turbidity measure method. After casting a pulse beam or a beam having a steep intensity gradient into an optical cavity, the turbidity of the inside region of the optical cavity can be calculated using an attenuation rate of an output beam from the optical cavity.