Patents by Inventor Guo-Liang Yu

Guo-Liang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-VEGF antibody
    Patent number: 7803371
    Abstract: An antibody is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain that comprises CDR regions that are substantially identical to the heavy chain CDR regions of a selected antibody and b) a light chain variable domain that comprises CDR regions that are substantially identical to the light chain CDR regions of the selected antibody, where the antibody binds a selected target.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: September 28, 2010
    Assignee: Epitomics, Inc.
    Inventors: Yaohuang Ke, Weimin Zhu, Guo-Liang Yu
  • Death domain containing receptor 5
    Patent number: 7803615
    Abstract: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: September 28, 2010
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Guo-Liang Yu, Jeffrey Y. Su, Craig A. Rosen
  • NOVEL HUMAN GROWTH FACTORS
    Publication number: 20100239564
    Abstract: The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
    Type: Application
    Filed: September 25, 2009
    Publication date: September 23, 2010
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Patrick J. Dillon, Reinhard Ebner, Gregory A. Endress
  • Human tumor necrosis factor receptor TR9 antibody
    Patent number: 7776560
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: August 17, 2010
    Assignee: Human Genome Scienes, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • CDR-Anchored Amplification Method
    Publication number: 20100204059
    Abstract: A method of obtaining nucleic acid encoding a plurality of antibodies is provided. In certain embodiments, the method comprises obtaining from an immunized animal nucleic acid encoding the amino acid sequence of the heavy and light chains of a second antibody that binds to the antigen as a first antibody and differs in amino acid sequence to the first antibody, wherein the obtaining is done by amplification using: i. a first primer pair that includes oligonucleotides are complementary to CDR-encoding regions first antibody.
    Type: Application
    Filed: January 28, 2010
    Publication date: August 12, 2010
    Inventors: Yaohuang Ke, Guo-Liang Yu
  • NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT
    Publication number: 20100196360
    Abstract: The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
    Type: Application
    Filed: September 12, 2008
    Publication date: August 5, 2010
    Applicant: Human Genome Sciences, Inc.
    Inventors: GUO-LIANG YU, Reinhard Ebner, Jian Ni, Craig A. Rosen, Stephen Ullrich
  • DR3 antibodies
    Patent number: 7708996
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: May 4, 2010
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Reiner L. Gentz, Patrick J. Dillon
  • Tumor necrosis factor receptors 6? and 6?
    Patent number: 7709218
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6? & -6? proteins. TNFR-6? & -6? polypeptides and antibodies that bind TNFR-6? & -6? polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6? & -6? activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: May 4, 2010
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Jian Ni, Ping Feng
  • YIELD-RELATED POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS
    Publication number: 20100107279
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: December 15, 2009
    Publication date: April 29, 2010
    Applicant: Mendel Biotechnology, Inc.
    Inventors: Oliver J. Ratcliffe, Jose Luis Riechmann, Luc Adam, Jacqueline E. Heard, Marsha L. Pilgrim, Cai-Zhong Jiang, T. Lynne Reuber, Robert A. Creelman, Omaira Pineda, Guo-Liang Yu
  • STRESS-RELATED POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS
    Publication number: 20100083395
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: October 12, 2009
    Publication date: April 1, 2010
    Applicant: Mendel Biotechnology, Inc.
    Inventors: T. Lynne Reuber, Jose Luis Riechmann, Jacqueline E. Heard, Cai-Zhong Jiang, Luc Adam, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Neal I. Gutterson, Frederick D. Hempel, Roderick W. Kumimoto, James S. Keddie
  • Polynucleotides and polypeptides in plants
    Patent number: 7659446
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods is also disclosed.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: February 9, 2010
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Bradley K. Sherman, Jose Luis Riechmann, Oliver Ratcliffe, Cai-Zhong Jiang, Jacqueline Heard, Volker Haake, Robert A. Creelman, Luc J. Adam, Lynne Reuber, James S. Keddie, Arnold Dubell, Omaira Pineda, Peter P. Repetti, Karen S. Century, Neal Gutterson, Guo-Liang Yu, Pierre Broun, Roderick Kumimoto, Marsha L. Pilgrim
  • Polynucleotides and Polypeptides in Plants
    Publication number: 20090276912
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: December 18, 2008
    Publication date: November 5, 2009
    Applicant: Mendel Biotechnology, Inc.
    Inventors: BRADLEY K. SHERMAN, Jose Luis Riechmann, Cai-Zhong Jiang, Jacqueline E. Heard, Volker Haake, Robert A. Creelman, Oliver Ratcliffe, Luc J. Adam, T. Lynne Reuber, James Keddie, Pierre E. Broun, Marsha L. Pilgrim, Arnold N. DuBell, III, Omaira Pineda, Guo-Liang Yu
  • Diagnostic methods involving human growth factor huXAG-1
    Patent number: 7611846
    Abstract: The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1, huXAG-2 and huXAG-3.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: November 3, 2009
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Patrick J. Dillon, Reinhard Ebner, Gregory A. Endress
  • ANTI-TNFalpha ANTIBODY
    Publication number: 20090269357
    Abstract: An antibody that binds TNF ? and neutralizes its activity is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO. 1, and b) a light chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID No. 2.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 29, 2009
    Inventors: YAOHUANG KE, Guo-Liang Yu
  • Stress-related polynucleotides and polypeptides in plants
    Patent number: 7601893
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 13, 2009
    Assignee: Mendel Biotechnology, Inc.
    Inventors: T. Lynne Reuber, Jose Luis Riechmann, Jacqueline E. Heard, Cai-Zhong Jiang, Luc Adam, Arnold N. Dubell, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre Broun
  • Tumor necrosis factor-gamma
    Patent number: 7597886
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: October 6, 2009
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
  • ANTI-VEGF ANTIBODY
    Publication number: 20090246190
    Abstract: An antibody is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain that comprises CDR regions that are substantially identical to the heavy chain CDR regions of a selected antibody and b) a light chain variable domain that comprises CDR regions that are substantially identical to the light chain CDR regions of the selected antibody, where the antibody binds a selected target.
    Type: Application
    Filed: October 8, 2008
    Publication date: October 1, 2009
    Inventors: Yaohuang Ke, Weimin Zhu, Guo-Liang Yu
  • Human Endokine Alpha and Methods of Use
    Publication number: 20090246202
    Abstract: The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
    Type: Application
    Filed: February 13, 2009
    Publication date: October 1, 2009
    Applicant: HUMAN GENOME SCIENCES, INC.
    Inventors: GUO-LIANG YU, JIAN NI, CRAIG A. ROSEN
  • Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta
    Publication number: 20090226456
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6? & -6? proteins. TNFR-6? & -6? polypeptides and antibodies that bind TNFR-6? & -6? polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6? & -6? activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: May 8, 2009
    Publication date: September 10, 2009
    Applicant: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Jian Ni, Ping Feng
  • NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT
    Publication number: 20090221008
    Abstract: The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
    Type: Application
    Filed: March 30, 2007
    Publication date: September 3, 2009
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen, Stephen Ullrich, Marc Chevrier