Patents by Inventor Guo-Liang Yu

Guo-Liang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NATURAL KILLER CELL ACTIVATING FACTOR II
    Publication number: 20060068463
    Abstract: The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Application
    Filed: July 11, 2002
    Publication date: March 30, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Haodong Li, Guo-Liang Yu, Reiner Gentz
  • 32 human secreted proteins
    Publication number: 20060025574
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 15, 2005
    Publication date: February 2, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Kenneth Carter, Patrick Dillon, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • 90 human secreted proteins
    Publication number: 20050244845
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: November 12, 2004
    Publication date: November 3, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Daniel Soppet, Reinhard Ebner, Henrik Olsen, Paul Young, John Greene, Ann Ferrie, Guo-Liang Yu, Jian Ni, Craig Rosen, Laurie Brewer, Fouad Janat, Charles Birse
  • Human tumor necrosis receptor TR9
    Publication number: 20050239123
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Application
    Filed: June 9, 2005
    Publication date: October 27, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner Gentz
  • 67 human secreted proteins
    Publication number: 20050239059
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 12, 2001
    Publication date: October 27, 2005
    Inventors: Steven Ruben, Ann Ferrie, Craig Rosen, Kimberly Florence, Kenneth Carter, Daniel Soppet, Guo-Liang Yu, Charles Florence, Paul Young, Jian Ni, Gregory Endress, Ping Feng, Fouad Janat, Charles Birse
  • Death domain containing receptor 5
    Publication number: 20050233958
    Abstract: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.
    Type: Application
    Filed: November 3, 2004
    Publication date: October 20, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner Gentz, Guo-Liang Yu, Craig Rosen
  • Death domain containing receptors
    Patent number: 6951735
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: October 4, 2005
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Guo-Liang Yu, Jian Ni, Vishva Dixit, Reiner L. Gentz, Patrick J. Dillon
  • 86 human secreted proteins
    Publication number: 20050214844
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: April 22, 2005
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Moore, Yanggu Shi, Craig Rosen, Steven Ruben, David Lafleur, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Paul Young, John Greene, Ann Ferrie, Guo-Liang Yu, Jian Ni, Ping Feng
  • VEGI, an inhibitor of angiogenesis and tumor growth
    Publication number: 20050214305
    Abstract: The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
    Type: Application
    Filed: December 14, 2004
    Publication date: September 29, 2005
    Applicants: Human Genome Sciences, Inc., Georgetown University Medical Center
    Inventors: Lu-Yuan Li, Yifan Zhai, Guo-Liang Yu, Jian Ni, Marc Lippman, Craig Rosen
  • 70 human secreted proteins
    Publication number: 20050215775
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: November 2, 2004
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Carrie Fischer, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Yanggu Shi
  • Human tumor necrosis factor receptor TR9
    Patent number: 6949358
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: September 27, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • Neutrokine-alpha and neutrokine-alpha splice variant
    Publication number: 20050186637
    Abstract: The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
    Type: Application
    Filed: February 10, 2005
    Publication date: August 25, 2005
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig Rosen, Stephen Ullrich
  • Human cystatin F
    Publication number: 20050186616
    Abstract: The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Application
    Filed: March 24, 2005
    Publication date: August 25, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Guo-Liang Yu, Reiner Gentz, Jian Ni
  • Yield-related polynucleotides and polypeptides in plants
    Publication number: 20050160493
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: August 9, 2002
    Publication date: July 21, 2005
    Inventors: Oliver Ratcliffe, Jose Riechmann, Luc Adam, Arnold Dubell, Jacqueline Heard, Marsha Pilgrim, Cai-Zhong Jiang, T. Reuber, Robert Creelman, Omaira Pineda, Guo-Liang Yu, Pierre Broun
  • Antibodies to human tumor necrosis factor receptor TR9
    Patent number: 6919078
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are antibodies, vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: July 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • Stress-related polynucleotides and polypeptides in plants
    Publication number: 20050120408
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: August 9, 2002
    Publication date: June 2, 2005
    Inventors: T. Reuber, Jose Riechmann, Jacqueline Heard, Cai-Zhong Jiang, Luc Adam, Arnold DuBell, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre Broun
  • Methods of treatment of immune system related disorders using Neutrokine-alpha
    Patent number: 6881401
    Abstract: The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: April 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen
  • Human chemotactic cytokine I polypeptides
    Publication number: 20050069945
    Abstract: Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
    Type: Application
    Filed: November 23, 2004
    Publication date: March 31, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Pedro Alfonso, Reiner Gentz, Jeffrey Su
  • 101 human secreted proteins
    Publication number: 20050069943
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: November 3, 2004
    Publication date: March 31, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Roxanne Duan, Steven Ruben, Kimberly Florence, John Greene, Craig Rosen, Paul Young, Ann Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni, Kenneth Carter, Gregory Endress, Ping Feng, David LaFleur, Yanggu Shi
  • Death domain containing receptor 5 antibodies
    Patent number: 6872568
    Abstract: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: March 29, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Guo-Liang Yu, Craig A. Rosen