Patents by Inventor Guo-Liang Yu

Guo-Liang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides and polypeptides in plants
    Patent number: 7345217
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: March 18, 2008
    Assignee: Mendel Biotechnology, Inc.
    Inventors: James Zhang, Michael E. Fromm, Jacqueline E. Heard, Jose Luis Riechmann, Luc Adam, Pierre E. Broun, Omaira Pineda, T. Lynne Reuber, James Keddie, Guo-Liang Yu, Cai-Zhong Jiang, Raymond Samaha, Marsha L. Pilgrim, Robert A. Creelman, Arnold N. DuBell, Oliver Ratcliffe, Roderick Kumimoto, Bradley K. Sherman
  • Cytostatin II antibodies and methods
    Patent number: 7314722
    Abstract: The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: January 1, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz
  • Human Tumor Necrosis Factor Receptor TR9
    Publication number: 20070298459
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Application
    Filed: July 20, 2007
    Publication date: December 27, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner Gentz
  • Tumor Necrosis Factor-Gamma
    Publication number: 20070297977
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Application
    Filed: August 10, 2007
    Publication date: December 27, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig Rosen, Jun Zhang
  • Antibodies to natural killer cell activating factor II
    Patent number: 7309780
    Abstract: The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: December 18, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Haodong Li, Guo-Liang Yu, Reiner L. Gentz
  • 32 Human Secreted Proteins
    Publication number: 20070248593
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: June 25, 2007
    Publication date: October 25, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Kenneth Carter, Patrick Dillon, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • Tumor necrosis factor receptors 6? & 6?
    Patent number: 7285267
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6? & -6? proteins. TNFR-6? & -6? polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6? & -6? activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: October 23, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Jian Ni, Ping Feng
  • 70 Human Secreted Proteins
    Publication number: 20070238664
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: May 22, 2007
    Publication date: October 11, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Carrie Fischer, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Yanggu Shi
  • Colon Specific Genes and Proteins
    Publication number: 20070212369
    Abstract: Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are disclosed.
    Type: Application
    Filed: May 14, 2007
    Publication date: September 13, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Craig Rosen
  • Yield-related polynucleotides and polypeptides in plants
    Publication number: 20070209086
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: March 26, 2007
    Publication date: September 6, 2007
    Applicant: Mendel Biotechnology
    Inventors: Oliver Ratcliffe, Jose Riechmann, Luc Adam, Arnold Dubell, Jacqueline Heard, Marsha Pilgrim, Cai-Zhong Jiang, T. Reuber, Robert Creelman, Omaira Pineda, Guo-Liang Yu, Pierre Broun
  • Stress-related polynucleotides and polypeptides in plants
    Publication number: 20070186308
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: March 16, 2007
    Publication date: August 9, 2007
    Applicant: Mendel Biotechnology
    Inventors: T. Reuber, Jose Riechmann, Jacqueline Heard, Cai-Zhong Jiang, Luc Adam, Arnold Dubell, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre Broun
  • Yield-related polynucleotides and polypeptides in plants
    Patent number: 7238860
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: July 3, 2007
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Oliver Ratcliffe, Jose Luis Riechmann, Luc J. Adam, Arnold N. DuBell, Jacqueline E. Heard, Marsha L. Pilgrim, Cai-Zhong Jiang, T. Lynne Reuber, Robert A. Creelman, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Human tumor necrosis factor delta polypeptides
    Patent number: 7217788
    Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: May 15, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Reiner L. Gentz
  • Stress-related polynucleotides and polypeptides in plants
    Patent number: 7193129
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: March 20, 2007
    Assignee: Mendel Biotechnology, Inc.
    Inventors: T. Lynne Reuber, Jose Luis Riechmann, Jacqueline E. Heard, Cai-Zhong Jiang, Luc J. Adam, Arnold N. DuBell, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Polynucleotides and polypeptides in plants
    Publication number: 20070061911
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: April 10, 2003
    Publication date: March 15, 2007
    Inventors: James Zhang, Michael Fromm, Jacqueline Heard, Jose Riechmann, Luc Adam, Pierre Broun, Omaira Pineda, T. Reuber, James Keddie, Guo-Liang Yu, Cai-Zhong Jiang, Raymond Samaha, Marsha Pilgrim, Robert Creelman, Arnold DuBell, Oliver Ratcliffe, Roderick Kumimoto, Bradley Sherman
  • Tumor necrosis factor 6? and 6?
    Patent number: 7186800
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6? & -6? proteins. TNFR-6? & -6? polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6? & -6? activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: March 6, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Jian Ni, Ping Feng
  • Methods of identifying plant disease-resistance genes
    Patent number: 7179601
    Abstract: The invention relates to a method of identifying a plant disease-resistance gene that includes the steps of (a) providing a plant tissue sample; (b)introducing by biolistic transformation into the plant tissue sample a candidate plant disease-resistance gene; (c) expressing the candidate plant disease-resistance gene within the plant tissue sample; and (d) determining whether the plant tissue sample exhibits a disease-resistance response, whereby a response identifies a plant disease-resistance gene.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: February 20, 2007
    Inventors: Frederick M. Ausubel, Brian J. Staskawicz, Andrew F. Bent, Douglas Dahlbeck, Fumiaki Katagiri, Barbara N. Kunkel, Michael Nicholas Mindrinos, Guo-Liang Yu, Barbara Baker, Jeffrey Ellis, John Salmeron
  • Human Endokine Alpha and Methods of Use
    Publication number: 20070009525
    Abstract: The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
    Type: Application
    Filed: June 30, 2006
    Publication date: January 11, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig Rosen
  • Biochemistry-related polynucleotides and polypeptides in plants
    Patent number: 7135616
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: November 14, 2006
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Robert A. Creelman, James Keddie, Marsha L. Pilgrim, Arnold N. DuBell, Cai-Zhong Jiang, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Polynucleotides and polypeptides in plants
    Publication number: 20060242738
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods is also disclosed.
    Type: Application
    Filed: February 25, 2004
    Publication date: October 26, 2006
    Applicant: Mendel Biotechnology
    Inventors: Bradley Sherman, Jose Riechmann, Oliver Ratcliffe, Cai-Zhong Jiang, Jacqueline Heard, Volker Haake, Robert Creelman, Luc Adam, Lynne Reuber, James Keddie, Omaira Pineda, Peter Repetti, Karen Century, Neal Gutterson, Guo-Liang Yu, Pierre Broun, Roderick Kumimoto, Marsha Pilgrim