Abstract: The present disclosure discloses a light source circuit and a lighting device. The light source circuit includes: a substrate, a light source mounted on a surface of the substrate, and an optical element assembled on the substrate; the substrate is provided with a first light source connection region and a second light source connection region; the optical element is provided with a first lens corresponding to the first light source connection region and is provided with a plurality of second lenses corresponding to the second light source connection region; and the light source at least includes a first light source arranged on the first light source connection region.

Abstract: A heteroaryl-pyrazole derivative, and a preparation method therefor and a medical application thereof are described. Specifically, a new heteroaryl-pyrazole derivative as shown in formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, and a use of the derivative as a therapeutic agent, in particular as a TLR7 agonist, are described. The substituents in formula (I) have the same definitions as in the description.

Abstract: The invention disclosed herein relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl compounds and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridinyl compounds of Formula (A), pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of autoimmune diseases.

Abstract: The lighting device includes a cover with a receiving chamber defined between a top wall and a side wall extending downwards from the top wall; an insulation component located on an inner surface of the side wall and having a receiving groove; a light source assembly located in the receiving groove; a light guide assembly received in the receiving chamber with an end received in the receiving groove; and a metal frame fixed at a periphery of the cover.

Abstract: The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), wherein A1, Y and Z all represent rings.

Abstract: The present disclosure discloses a light source circuit and a lighting device. The light source circuit includes: a substrate, a light source mounted on a surface of the substrate, and an optical element assembled on the substrate; the substrate is provided with a first light source connection region and a second light source connection region; the optical element is provided with a first lens corresponding to the first light source connection region and is provided with a plurality of second lenses corresponding to the second light source connection region; and the light source at least includes a first light source arranged on the first light source connection region.

Abstract: The present disclosure discloses a lighting device. The lighting device includes: a cover including a top wall and a side wall extending downwards from the top wall, a receiving chamber that is delimited by the top wall and the side wall; an insulation component located on an inner surface of the side wall of the cover and provided with a receiving groove; a light source assembly located on a surface of an inner wall of the receiving groove of the insulation component; a light guide assembly received in the receiving chamber of the cover, where the light guide assembly includes an end received in the receiving groove of the insulation component; and a metal frame fixed at a periphery of the cover.

Abstract: The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), wherein A1, Y and Z all represent rings.

Abstract: The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), wherein A1, Y and Z all represent rings.

Abstract: The present invention relates to compositions and methods for modulating the Wnt signaling pathway.

Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Abstract: The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.

Abstract: The present invention relates to compositions and methods for modulating the Wnt signaling pathway.

Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.

Abstract: The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings.

Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Abstract: The invention provides a novel class of compounds having Formula Ia, wherein each variable is as defined; and pharmaceutical compositions comprising such compounds and methods of using such compounds for inhibiting c-Src, FGFR3, KDR and/or Lck.

Abstract: The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.

Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.