Patents by Inventor Guobao Zhang

Guobao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions as protein kinase inhibitors
    Patent number: 7371750
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: May 13, 2008
    Assignee: IRM LLC
    Inventors: Taebo Sim, Hyun Soo Lee, Pingda Ren, Qiang Ding, Guobao Zhang, Yi Liu, Xia Wang, Tetsuo Uno, Bing Li, Lintong Li, Nathanael Schiander Gray, Shuli You
  • Compounds and Compositions as Protein Kinase Inhibitors
    Publication number: 20070225286
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ??K, Tt?2, ???, ?NK2?2, MKK4, c-RAF, MKK6, SAPK2? and SAPK2? kinases.
    Type: Application
    Filed: June 9, 2005
    Publication date: September 27, 2007
    Inventors: Pingda Ren, Xia Wang, Guobao Zhang, Qiang Ding, Shull You, Qiong Zhang, Greg Chopiuk, Pamela Albaugh, Taebo Sim, Nathanael Gray
  • Borellia burgdorferi epitope peptides
    Patent number: 7045134
    Abstract: Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: May 16, 2006
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Bo Qiu, Guobao Zhang, Stanley Stein, Leonard Sigal, Michael Brunner, Michael Katz
  • Compounds and compositions as protein kinase inhibitors
    Publication number: 20050222177
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
    Type: Application
    Filed: July 29, 2004
    Publication date: October 6, 2005
    Applicant: IRM LLC
    Inventors: Taebo Sim, Hyun Lee, Pingda Ren, Qiang Ding, Yi Liu, Bing Li, Lintong Li, Xia Wang, Tetsuo Uno, Guobao Zhang, Nathanael Gray, Shuli You
  • Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances
    Patent number: 6913936
    Abstract: A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of kits for immunological assays.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: July 5, 2005
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Bo Qiu, Guobao Zhang, Stanley Stein, Leonard H Sigal, Michael Brunner, Michael Katz
  • Compounds and compositions as inhibitors of receptor tyrosine kinase activity
    Publication number: 20050124637
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFR? kinase activity.
    Type: Application
    Filed: August 13, 2004
    Publication date: June 9, 2005
    Applicant: IRM LLC
    Inventors: Dai Cheng, Qiang Ding, Dong Han, Nathanael Gray, Guobao Zhang
  • Novel compounds and compositions as protein kinase inhibitors
    Publication number: 20050014753
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl.
    Type: Application
    Filed: April 1, 2004
    Publication date: January 20, 2005
    Applicant: IRM LLC
    Inventors: Qiang Ding, Taebo Sim, Guobao Zhang, Francisco Adrian, Nathanael Gray
  • Multiple epitopes connected by a carrier
    Publication number: 20030040127
    Abstract: Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay
    Type: Application
    Filed: October 17, 2001
    Publication date: February 27, 2003
    Inventors: Bo Qiu, Stanley Stein, Guobao Zhang, Leonard Sigal, Michael Brunner, Michael Katz
  • Immunological test kit with immunologically invisible carrier
    Publication number: 20030040126
    Abstract: Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
    Type: Application
    Filed: October 17, 2001
    Publication date: February 27, 2003
    Inventors: Bo Qiu, Guobao Zhang, Stanley Stein, Leonard H. Sigal, Michael Brunner, Michael Katz
  • Poly (ethylene glycol) copolymers
    Publication number: 20030031674
    Abstract: Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
    Type: Application
    Filed: October 17, 2001
    Publication date: February 13, 2003
    Inventors: Bo Qiu, Guobao Zhang, Stanley Stein, Leonard Sigal, Michael Brunner, Michael Katz
  • Borellia burgdorferi epitope peptides
    Publication number: 20020197271
    Abstract: Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
    Type: Application
    Filed: October 17, 2001
    Publication date: December 26, 2002
    Inventors: Bo Qiu, Guobao Zhang, Stanely Stein, Leonard Sigal, Michael Brunner, Michael Katz
  • Controlled release of thioamide moiety-containing therapeutic agents
    Patent number: 6468522
    Abstract: This invention pertains to disulfide-linked conjugates of therapeutic agents containing at least one thioamide group with polymer comprising at least one thiol group, so as to provide a controlled release pharmaceutical composition for administration to animals for the prophylaxis or treatment of various conditions or diseases. The therapeutic agent conjugate may comprise an inactive or weakly active prodrug form which may be converted into the original therapeutic compound by the natural action of reducing agents in vivo. The composition may comprise a mixture of polymers each with a different thioamide-containing agent attached, or a polymer conjugated with a mixture of thioamide-containing agents.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 22, 2002
    Assignees: University of Medicine and Dentistry of New Jersey, Rutgers, the State University of New Jersey
    Inventors: Stanley Stein, Guobao Zhang, Bo Qiu
  • Materials and processes for controlled release of thioamide moiety-containing therapeutic agents by linking to thiol-containing polymers
    Publication number: 20020122785
    Abstract: This invention pertains to disulfide-linked conjugates of therapeutic agents containing at least one thioamide group with polymer comprising at least one thiol group, so as to provide a controlled release pharmaceutical composition for administration to animals for the prophylaxis or treatment of various conditions or diseases. The therapeutic agent conjugate may comprise an inactive or weakly active prodrug form which may be converted into the original therapeutic compound by the natural action of reducing agents in vivo. The composition may comprise a mixture of polymers each with a different thioamide-containing agent attached, or a polymer conjugated with a mixture of thioamide-containing agents.
    Type: Application
    Filed: May 1, 2002
    Publication date: September 5, 2002
    Inventors: Stanley Stein, Guobao Zhang, Bo Qiu
  • Immunological test kit with borellia burgdorferi epitope
    Publication number: 20020106706
    Abstract: Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
    Type: Application
    Filed: October 17, 2001
    Publication date: August 8, 2002
    Inventors: Bo Qiu, Stanley Stein, Guobao Zhang, Leonard Sigal, Michael Brunner, Michael Katz