Patents by Inventor Han-Cheng Zhang

Han-Cheng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrroline kinase inhibitors
    Patent number: 7524858
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: April 28, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20090093515
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: September 22, 2008
    Publication date: April 9, 2009
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
  • Substituted pyrroline kinase inhibitors
    Publication number: 20090093634
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: September 22, 2008
    Publication date: April 9, 2009
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
  • Substituted pyrroline kinase inhibitors
    Patent number: 7488826
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: February 10, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
  • Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists
    Publication number: 20080312257
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein X1, X2, R1, R2, R3 and R4 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 18, 2008
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Cailin Chen
  • SPIROBENZOAZEPANES AS VASOPRESSIN ANTAGONISTS
    Publication number: 20080306044
    Abstract: The present invention is directed to a compound of Formula (I) or a form thereof: wherein U, V, W and Ring A are as defined herein, useful as vasopressin receptor antagonists.
    Type: Application
    Filed: June 6, 2008
    Publication date: December 11, 2008
    Inventors: MICHAEL J. COSTANZO, David F. McComsey, Stephen C. Yabut, Han-Cheng Zhang
  • Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors
    Patent number: 7439363
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): R2 is selected from the group consisting of —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z; wherein the —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z and Z is a 5 to 6 member aromatic monocyclic heteroaryl ring having from 2 to 4 heteroatoms. These compounds are useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: October 21, 2008
    Assignee: Janssen Parmaceutica N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
  • Indazole peptidomimetics as thrombin receptor antagonists
    Patent number: 7417030
    Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: August 26, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Anjali Pandey, Robert M. Scarborough
  • Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists
    Publication number: 20080108635
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein R1 and R2 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Hong Ye, Cailin Chen
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20080096949
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: December 13, 2007
    Publication date: April 24, 2008
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Hecker, David McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 7329657
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: February 12, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 7304060
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: December 4, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Pyridine-containing macroheterococylic compounds as kinase inhibitors
    Publication number: 20070213352
    Abstract: This invention is directed to pyridine-containing macroheterocyclic compounds useful as kinase inhibitors, methods for producing such compounds and methods for treating or preventing a kinase mediated disorder.
    Type: Application
    Filed: March 9, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Llorente Vicente R. Bonaga, Claudia K. Derian, Bruce E. Maryanoff, Hong Ye
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213387
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213386
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7232906
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 19, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Macroheterocyclic compounds as kinase inhibitors
    Publication number: 20070088019
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disease, condition or disorder.
    Type: Application
    Filed: September 27, 2006
    Publication date: April 19, 2007
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye
  • Indole peptidomimetics as thrombin receptor antagonists
    Patent number: 7183252
    Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: February 27, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Patent number: 7125878
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: October 24, 2006
    Assignee: Janssen Pharmaceutica
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205763
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey