Patents by Inventor Han-Cheng Zhang

Han-Cheng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel indole peptidomimetics as thrombin receptor antagonists
    Publication number: 20030224999
    Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 31, 2003
    Publication date: December 4, 2003
    Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
  • Novel indazole peptidomimetics as thrombin receptor antagonists
    Publication number: 20030199455
    Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 31, 2003
    Publication date: October 23, 2003
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Anjali Pandey, Robert M. Scarborough
  • Benzimidazolone peptidometics as thrombin receptor antagonist
    Patent number: 6630451
    Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: October 7, 2003
    Assignee: OrthoMcNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly B. White
  • Macroheterocylic compounds useful as kinase inhibitors
    Publication number: 20030078280
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: December 6, 2001
    Publication date: April 24, 2003
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20030055097
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): 1
    Type: Application
    Filed: December 6, 2001
    Publication date: March 20, 2003
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists
    Publication number: 20020160963
    Abstract: The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.
    Type: Application
    Filed: January 29, 2002
    Publication date: October 31, 2002
    Inventors: Bruce E. Maryanoff, Han-Cheng Zhang, David F. McComsey
  • Indole and indazole urea-peptoids as thrombin receptor antagonists
    Patent number: 6365617
    Abstract: The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: April 2, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: David F. McComsey, William J. Hoekstra, Bruce E. Maryanoff, Han-Cheng Zhang