Patents by Inventor Handong Li

Handong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8859734
    Abstract: The embodiments of the invention relate to a method for the introduction of a labeling structure such as a fluorescent molecules or a Raman tags to a compound. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: October 14, 2014
    Assignee: Intel Corporation
    Inventors: Handong Li, Narayan Sundararajan
  • Publication number: 20140203392
    Abstract: A semiconductor radiation detector having a semiconductor substrate and first and second metal layers. The semiconductor substrate has substantially planar upper and lower opposing surfaces which have respective first and second surface areas. The first and second surface areas are defined by prospective dice lines. The first metal layer is on the substantially planar upper surface such that the first metal layer will have a surface area less than the first surface area of the substantially planar upper surface as defined by spaces on the substantially planar upper surface between the first metal layer and the prospective dice lines which define the first surface area. The second metal layer is on the substantially planar lower opposing surface.
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Inventors: Handong Li, Michael Prokesch, John F. Eger
  • Publication number: 20140178862
    Abstract: Photoinduced redox current (PIRC) detection for DNA sequencing using integrated transducer arrays is described. For example, a method of determining DNA sequencing using photoinduced redox current (PIRC) includes providing a template having a primer region and a second region of one or more unknown bases. The template is coupled to a transducer array. The method also includes incorporating a tagged nucleotide at the second region of the template. The method also includes exposing the template to a light source. The method also includes electrically detecting, by the transducer, a state of the template. The method also includes removing a photosensitizer tag of the tagged nucleotide.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 26, 2014
    Inventors: Xing Su, Handong Li
  • Patent number: 8742522
    Abstract: A method of making a semiconductor radiation detector wherein the metal layers which serve as the cathode and anode electrodes are recessed from the designated prospective dice lines which define the total upper and lower surface areas for each detector such that the dicing blade will not directly engage the metal during dicing and therefore prevent metal from intruding upon (smearing) the vertical side walls of the detector substrate.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: June 3, 2014
    Assignee: eV Products, Inc.
    Inventors: Handong Li, Michael Prokesch, John F. Eger
  • Patent number: 8658093
    Abstract: System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: February 25, 2014
    Assignee: Applied Biosystems, LLC
    Inventors: Aldrich N. K. Lau, Robert G. Eason, Kristian M. Scaboo, Handong Li
  • Patent number: 8647821
    Abstract: Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
    Type: Grant
    Filed: December 22, 2012
    Date of Patent: February 11, 2014
    Assignee: Intel Corporation
    Inventors: Hernan A. Castro, Gordon D. Holt, Brandon C. Barnett, Handong Li, Narayanan Sundararajan, Wei Wang
  • Publication number: 20140001055
    Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 2, 2014
    Inventors: Oguz H. Elibol, Grace M. Credo, Xing Su, Madoo Varma, Jonathan S. Daniels, Drew Hall, Handong Li, Noureddine Tayebi, Kai Wu
  • Publication number: 20130264669
    Abstract: A method of making a semiconductor radiation detector wherein the metal layers which serve as the cathode and anode electrodes are recessed from the designated prospective dice lines which define the total upper and lower surface areas for each detector such that the dicing blade will not directly engage the metal during dicing and therefore prevent metal from intruding upon (smearing) the vertical side walls of the detector substrate.
    Type: Application
    Filed: April 10, 2012
    Publication date: October 10, 2013
    Applicant: Endicott Interconnect Technologies, Inc.
    Inventors: Handong Li, Michael Prokesch, John Francis Eger
  • Publication number: 20130186767
    Abstract: Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
    Type: Application
    Filed: December 22, 2012
    Publication date: July 25, 2013
    Inventors: Hernan Adolfo CASTRO, Gordon Holt, Brandon Barnett, Handong Li, Narayan Sundararajan, Wei Wang
  • Patent number: 8338097
    Abstract: Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: December 25, 2012
    Assignee: Intel Corporation
    Inventors: Hernan Castro, Gordon Holt, Brandon Barnett, Handong Li, Narayan Sundararajan, Wei Wang
  • Patent number: 8294025
    Abstract: Lateral collection photovoltaic (LCP) structures based on micro- and nano-collecting elements are used to collect photogenerated carriers. In one set of embodiments, the collecting elements are arrayed on a conducting substrate. In certain versions, the collecting elements are substantially perpendicular to the conductor. In another set of embodiments, the micro- or nano-scale collecting elements do not have direct physical and electrical contact to any conducting substrate. In one version, both anode and cathode electrodes are laterally arrayed. In another version, the collecting elements of one electrode are a composite wherein a conductor is separated by an insulator, which is part of each collector element, from the opposing electrode residing on the substrate. In still another version, the collection of one electrode structure is a composite containing both the anode and the cathode collecting elements for collection. An active material is positioned among the collector elements.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: October 23, 2012
    Assignee: Solarity, LLC
    Inventors: Stephen J. Fonash, Handong Li, David Stone
  • Publication number: 20120045767
    Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
    Type: Application
    Filed: August 22, 2011
    Publication date: February 23, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Aldrich LAU, Robert Eason, Maxim Brevnov, Handong Li, Kevin Hacker
  • Publication number: 20110224092
    Abstract: Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
    Type: Application
    Filed: March 14, 2011
    Publication date: September 15, 2011
    Applicant: INTEL CORPORATION
    Inventors: Hernan Adolfo CASTRO, Gordon Holt, Brandon Barnett, Handong Li, Narayan Sundararajan, Wei Wang
  • Patent number: 8003408
    Abstract: A SERS active particle having a metal-containing particle and a cationic coating on the metal-containing particle, wherein the SERS active particle carries a positive charge is disclosed. Also, a SERS active particle having a metal-containing particle and a non-metallic molecule, wherein the metal-containing particle is derivatized with the non-metallic molecule is disclosed. In addition, several methods of modifying the nanoparticles surfaces of a SERS active particle and of improving the interaction between the SERS active particle and an analyte are disclosed.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: August 23, 2011
    Assignee: Intel Corporation
    Inventors: Jingwu Zhang, Narayan Sundararajan, Sarah M. Ngola, Handong Li
  • Publication number: 20110159305
    Abstract: Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.
    Type: Application
    Filed: March 10, 2011
    Publication date: June 30, 2011
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Steven M. MENCHEN, Christina E. Inman, Meng Taing, Khai Luong, Handong Li
  • Patent number: 7928038
    Abstract: Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: April 19, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Steven M. Menchen, Christina E. Inman, Meng Taing, Khai Luong, Handong Li
  • Patent number: 7923237
    Abstract: Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: April 12, 2011
    Assignee: Intel Corporation
    Inventors: Hernan Adolfo Castro, Gordon Holt, Brandon Barnett, Handong Li, Narayan Sundararajan, Wei Wang
  • Patent number: 7753987
    Abstract: The present invention concerns a high vacuum in-situ refining method for high-purity and superhigh-purity materials and the apparatus thereof, characterized in heating the upper part and lower part of crucible separately using double-heating-wires diffusion furnace under vacuum, thereby forming the temperature profile which is high at upper part and low at lower part of crucible, or in reverse during different stages; then heating the crucible in two steps to remove impurities with high saturation vapor pressure and low saturation vapor pressure respectively in efficiency; and obtaining high-purity materials eventually. The whole procedure is isolated from atmosphere, reducing contamination upon stuff remarkably. The present invention could provide products with high-quality and high production capacity, which are stable in performance, therefore is reliable and free from contamination.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: July 13, 2010
    Assignee: The Chinese Academy of Sciences Institute of Physics
    Inventors: Xiaolong Du, Zhaoquan Zeng, Hongtao Yuan, Handong Li, Qikun Xue, Jinfeng Jia
  • Patent number: 7709612
    Abstract: A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(?O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP(J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: May 4, 2010
    Assignee: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Vankatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Publication number: 20090142772
    Abstract: System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
    Type: Application
    Filed: July 3, 2008
    Publication date: June 4, 2009
    Applicant: Applied Biosystems Inc.
    Inventors: Aldrich N.K. Lau, Robert G. Eason, Kristian M. Scaboo, Handong Li