Patents by Inventor Handong Li

Handong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190144482
    Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
    Type: Application
    Filed: April 21, 2017
    Publication date: May 16, 2019
    Inventors: Handong Li, Snezana Drmanac, Radoje Drmanac, Xun Xu, Lingling Peng, Scott Gablenz
  • Patent number: 10190162
    Abstract: Novel fluorescent nucleotide analogs are provided herein. Also provided herein are methods of using the nucleotide analogs in sequencing-by-synthesis and signal confinement methods.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: January 29, 2019
    Assignee: Complete Genomics, Inc.
    Inventors: Snezana Drmanac, Handong Li, Radoje Drmanac, Eric Harness, Chongjun Xu
  • Patent number: 10175190
    Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: January 8, 2019
    Assignee: INTEL CORPORATION
    Inventors: Noureddine Tayebi, Xing Su, Handong Li
  • Publication number: 20180282800
    Abstract: Improved single molecule sequencing methods, compositions, and devices, are provided. In a first aspect, the present invention provides a multi-pass method of sequencing a target sequence using nanopore sequencing, the method comprising: i) providing a non-naturally occurring concatemer nucleic acid molecule comprising a plurality of copies of the target sequence; ii) nanopore sequencing at least three copies of the target sequence in the concatemer, thereby obtaining a multi-pass sequence dataset, wherein the multi-pass sequence dataset comprises target sequence datasets for the at least three copies of the target sequence; and iii) using the multi-pass sequence dataset to determine the target sequence.
    Type: Application
    Filed: November 10, 2015
    Publication date: October 4, 2018
    Applicant: BGI Shenzhen Co., Ltd.
    Inventors: Handong LI, Y. Tom TANG, Jing YU, Hui JIANG, Wenwei ZHANG, Guangyi FAN, He ZHANG, Kailong MA, Chunyu GENG
  • Publication number: 20180223358
    Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
    Type: Application
    Filed: January 4, 2018
    Publication date: August 9, 2018
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu, Matthew J. Callow, Leon Eckhardt, Naibo Yang, Quan Ding
  • Publication number: 20180180567
    Abstract: Provided is a microwell electrode, comprising one or more first electrodes (301); one or more second electrodes (303) each arranged opposite to one first electrode (301), wherein a channel (601) is provided between each first electrode and the second electrode opposite thereto, and the channel (601) has at least one end in communication with a chamber; and one or more guiding electrodes (501) located in the chamber (401). The microwell electrode electrode can sensitively detect a signal and improve the read length of a sequencer greatly. The invention further relates to a method for manufacturing the micro-porous electrode, a microwell electrode array, a sensor chip, a sequencing system, and a method for analysis of a chemical substance and a nucleic acid molecule based on the microwell electrode.
    Type: Application
    Filed: June 23, 2016
    Publication date: June 28, 2018
    Inventors: Handong LI, Jianxun LIN, Quanxin YUN, Shaohua XIANG, Radoje DRMANAC, Snezana DRMANAC, Yongwei ZHANG
  • Publication number: 20170240961
    Abstract: Nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
    Type: Application
    Filed: February 23, 2017
    Publication date: August 24, 2017
    Applicant: Complete Genomics, Inc.
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu
  • Publication number: 20170234825
    Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detections using transducer arrays. In one embodiment, a transducer array made up of a plurality of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can have a single molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap suitable for conducting redox cycling reactions. In embodiments, by flowing chamber contents, from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule, in the reaction chamber of the at least one transducer element through the fingerprinting region, the redox cycling reactions can be detected to identify the redox-tagged biomolecules.
    Type: Application
    Filed: December 13, 2016
    Publication date: August 17, 2017
    Inventors: Oguz H. ELIBOL, Grace M. CREDO, Xing SU, Madoo VARMA, Jonathan S. DANIELS, Drew HALL, Handong LI, Noureddine TAYEBI, Kai WU
  • Patent number: 9634163
    Abstract: A nanostructured or microstructured array of elements on a conductor layer together form a device electrode of a photovoltaic or detector structure. The array on the conductor layer has a high surface area to volume ratio configuration defining a void matrix between elements. An active layer or active layer precursors is disposed into the void matrix as a liquid to form a thickness coverage giving an interface on which a counter-electrode is positioned parallel to the conduction layer or as a vapor to form a conformal thickness coverage of the array and conduction layer. The thickness coverage is controlled to enhance collection of at least one of electrons and holes arising from photogeneration, or excitons arising from photogeneration, to the device electrode or a device counter-electrode as well as light absorption in said active layer via reflection and light trapping of said device electrode.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: April 25, 2017
    Assignee: LCCM Solar, LLC
    Inventors: Stephen J. Fonash, Handong Li, David Stone
  • Patent number: 9551682
    Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 24, 2017
    Assignee: INTEL CORPORATION
    Inventors: Oguz H. Elibol, Grace M. Credo, Xing Su, Madoo Varma, Jonathan S. Daniels, Drew Hall, Handong Li, Noureddine Tayebi, Kai Wu
  • Patent number: 9464109
    Abstract: A method for the introduction of a labeling structure such as fluorescent molecules or a Raman tag to a compound is described. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups is described. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: October 11, 2016
    Assignee: INTEL CORPORATION
    Inventors: Handong Li, Narayan Sundararajan
  • Publication number: 20160245774
    Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 25, 2016
    Inventors: Noureddine Tayebi, Xing Su, Handong Li
  • Patent number: 9417233
    Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: August 16, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Aldrich Lau, Robert Eason, Maxim Brevnov, Handong Li, Kevin Hacker
  • Patent number: 9354195
    Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: May 31, 2016
    Assignee: Intel Corporation
    Inventors: Noureddine Tayebi, Xing Su, Handong Li
  • Publication number: 20160130647
    Abstract: Novel fluorescent nucleotide analogues are provided herein. Also provided herein are methods of using the nucleotide analogues in sequencing-by-synthesis and signal confinement methods.
    Type: Application
    Filed: October 23, 2015
    Publication date: May 12, 2016
    Inventors: Snezana Drmanac, Handong Li, Radoje Drmanac, Eric Harness, Chongjun Xu
  • Patent number: 9318627
    Abstract: A semiconductor radiation detector having a semiconductor substrate and first and second metal layers. The semiconductor substrate has substantially planar upper and lower opposing surfaces which have respective first and second surface areas. The first and second surface areas are defined by prospective dice lines. The first metal layer is on the substantially planar upper surface such that the first metal layer will have a surface area less than the first surface area of the substantially planar upper surface as defined by spaces on the substantially planar upper surface between the first metal layer and the prospective dice lines which define the first surface area. The second metal layer is on the substantially planar lower opposing surface.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: April 19, 2016
    Assignee: eV Products, Inc.
    Inventors: Handong Li, Michael Prokesch, John F. Eger
  • Publication number: 20150197743
    Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 16, 2015
    Inventors: Aldrich Lau, Robert Eason, Maxim Brevnov, Handong Li, Kevin Hacker
  • Publication number: 20150168341
    Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 18, 2015
    Inventors: Noureddine Tayebi, Xing Su, Handong Li
  • Patent number: 8945509
    Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: February 3, 2015
    Assignee: Life Technologies Corporation
    Inventors: Aldrich Lau, Robert Eason, Maxim Brevnov, Handong Li, Kevin Hacker
  • Publication number: 20150031853
    Abstract: The embodiments of the invention relate to a method for the introduction of a labeling structure such as a fluorescent molecules or a Raman tags to a compound. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 29, 2015
    Inventors: Handong LI, Narayan SUNDARARAJAN