Patents by Inventor Handong Li

Handong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7033520
    Abstract: A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(?O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP(J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: April 25, 2006
    Assignee: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Venkatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Publication number: 20050123968
    Abstract: A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 ?g/cm2.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 9, 2005
    Applicant: Sigma-Aldrich Co.,
    Inventors: John Dapron, William Kappel, Handong Li
  • Publication number: 20050119415
    Abstract: A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 ?g/cm2.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 2, 2005
    Applicant: Sigma-Aldrich Co.
    Inventors: John Dapron, William Kappel, Handong Li
  • Publication number: 20050118709
    Abstract: A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 ?g/cm2.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 2, 2005
    Applicant: Sigma-Aldrich Co.
    Inventors: John Dapron, William Kappel, Handong Li
  • Publication number: 20050003496
    Abstract: Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. Methods for making such heterocyclic compounds are also disclosed. The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
    Type: Application
    Filed: December 23, 2003
    Publication date: January 6, 2005
    Applicant: Affymetrix, INC.
    Inventors: Glenn McGall, Anthony Barone, Handong Li
  • Patent number: 6825032
    Abstract: A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 &mgr;g/cm2.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: November 30, 2004
    Assignee: Sigma-Aldrich Co.
    Inventors: John Dapron, William Karl Kappel, Handong Li
  • Publication number: 20040234788
    Abstract: In one aspect of the invention, photoactivatable silane compounds and methods for their synthesis and use are provided. In one embodiment, the photoactivatable silane compounds synthesized are represented by a formula: PG-LS-SN, wherein PG is a photoactivatable group, LS is a linkage and spacer group, and SN is a silane group. The silanes allow the photoactivatable silane compounds to be covalently bound to the surface of a substrate such as silica. The photoactivatable group forms a hydrophobic layer that can be photochemically cross-linked with a layer of hydrophilic functional polymers. In another embodiment, a method is disclosed to synthesize a substrate of hydrophobic layers and hydrophilic functional polymer layers thereafter onto glass surfaces. An array of biopolymers such as nucleic acids and peptides may then be covalently attached to the substrate using photolithography and biopolymer synthesis.
    Type: Application
    Filed: June 28, 2004
    Publication date: November 25, 2004
    Applicant: Affymetrix, INC.
    Inventors: Handong Li, Glenn McGall
  • Patent number: 6773888
    Abstract: In one aspect of the invention, photoactivatable silane compounds and methods for their synthesis and use are provided. In one embodiment, the photoactivatable silane compounds synthesized are represented by a formula: PG-LS-SN, wherein PG is a photoactivatable group, LS is a linkage and spacer group, and SN is a silane group. The silanes allow the photoactivatable silane compounds to be covalently bound to the surface of a substrate such as silica. The photoactivatable group forms a hydrophobic layer that can be photochemically cross-linked with a layer of hydrophilic functional polymers. In another embodiment, a method is disclosed to synthesize a substrate of hydrophobic layers and hydrophilic functional polymer layers thereafter onto glass surfaces. An array of biopolymers such as nucleic acids and peptides may then be covalently attached to the substrate using photolithography and biopolymer synthesis.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: August 10, 2004
    Assignee: Affymetrix, Inc.
    Inventors: Handong Li, Glenn McGall
  • Publication number: 20040092031
    Abstract: A metal chelating composition having the formula: 1
    Type: Application
    Filed: September 22, 2003
    Publication date: May 13, 2004
    Applicant: Sigma - Aldrich Co.
    Inventors: William K. Kappel, Venkatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Publication number: 20030194715
    Abstract: In one aspect of the invention, photoactivatable silane compounds and methods for their synthesis and use are provided. In one embodiment, the photoactivatable silane compounds synthesized are represented by a formula: PG-LS—SN, wherein PG is a photoactivatable group, LS is a linkage and spacer group, and SN is a silane group. The silanes allow the photoactivatable silane compounds to be covalently bound to the surface of a substrate such as silica. The photoactivatable group forms a hydrophobic layer that can be photochemically cross-linked with a layer of hydrophilic functional polymers. In another embodiment, a method is disclosed to synthesize a substrate of hydrophobic layers and hydrophilic functional polymer layers thereafter onto glass surfaces. An array of biopolymers such as nucleic acids and peptides may then be covalently attached to the substrate using photolithography and biopolymer synthesis.
    Type: Application
    Filed: July 9, 2002
    Publication date: October 16, 2003
    Applicant: Affymetrix, INC.
    Inventors: Handong Li, Glenn H. McGall
  • Patent number: 6623655
    Abstract: A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is —A—T—CH(X)— or —C(═O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP (J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: September 23, 2003
    Assignee: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Venkatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Publication number: 20030157783
    Abstract: The invention relates to methods for preparing a removable system on a mother substrate. The method deposits a high surface to volume sacrificial layer on a mother substrate and stabilizes the sacrificial layer by a) removing volatile chemical species in and on the sacrificial layer and/or b) modifying the surface of the layer. The method coats over the sacrificial layer with a capping medium. A system is the fabricated on the capping medium. The method provides through holes to access the sacrificial layer. The method may also apply a top layer onto the system to form a covered system. The invention also includes the step of removing the sacrificial layer to release the system from the mother substrate. Methods of the invention also include selectively removing a portion of the system and capping layers to form void regions defining an array of islands composed of device, structure, or system and capping layer regions, and optionally filling the island-defining void region with a sacrificial material.
    Type: Application
    Filed: January 13, 2003
    Publication date: August 21, 2003
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Stephen J. Fonash, Handong Li, Youngchul Lee, Joseph D. Cuiffi, Daniel J. Hayes
  • Publication number: 20030032013
    Abstract: A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 &mgr;g/cm2.
    Type: Application
    Filed: May 14, 2001
    Publication date: February 13, 2003
    Inventors: John Dapron, William Karl Kappel, Handong Li