Abstract: Methods, systems, and computer programs are presented for adjusting bonus winning odds while playing an online slots game. One method includes an operation for receiving user input during a session of an online slots game, where the user input is defined to spin wheels of the online slots game. In addition, the method includes an operation for defining an initial tier and one or more additional tiers for play of the online slots game during the session, each tier being assigned an odds value that changes with each assigned tier, and each tier being defined to have a set of spins. Further, the method includes operations for assigning tiers with changed odds when an option to play a bonus game is not presented during the predefined set of spins for each tier, and for assigning the initial tier upon determining that the bonus game was played during the session.

Abstract: This invention discloses 3-aminobenzamide derivatives as ?-lactam antibiotic adjuvants of chemical formula (I), processes for preparing them and their use. The derivatives can act as ?-lactam antibiotic adjuvants for the treatment of methicillin-resistant staphylococcal infections.

Abstract: Filamenting temperature-sensitive mutant Z (FtsZ) protein plays a crucial role in the bacterial cell division machinery and is a validated drug target for antibacterial agents. The present invention relates to FtsZ-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine scaffold. Some of these compounds possess potent anti-staphylococcal properties and potent antibacterial activities against clinically isolated MRSA strains. Compounds have been identified to exhibit low spontaneous frequency of resistance, low toxicity as well as the ability to rescue G. mellonella larvae infected with lethal dose of the MRSA ATCC 43300 strain. Characterization by saturation transfer difference NMR, light scattering assay and GTPase hydrolysis assay with purified S. aureus FtsZ protein verified the interaction of 2,4,6-trisubstituted pyrimidine with the FtsZ protein, further confirmed by observations of iconic filamentous cell phenotype and mislocalization of the Z-ring formation.

Abstract: Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(?)-EGCG]. Use of Pro-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.

Abstract: Methods, systems, and computer programs are presented for adjusting bonus winning odds while playing an online slots game. One method includes an operation for receiving user input during a session of an online slots game, where the user input is defined to spin wheels of the online slots game. In addition, the method includes an operation for defining an initial tier and one or more additional tiers for play of the online slots game during the session, each tier being assigned an odds value that changes with each assigned tier, and each tier being defined to have a set of spins. Further, the method includes operations for assigning tiers with changed odds when an option to play a bonus game is not presented during the predefined set of spins for each tier, and for assigning the initial tier upon determining that the bonus game was played during the session.

Abstract: Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(?)-EGCG]. Use of Pro-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.

Abstract: Methods, systems, and computer programs are presented for adjusting bonus winning odds while playing an online slots game. One method includes an operation for receiving user input during a session of an online slots game, where the user input is defined to spin wheels of the online slots game. In addition, the method includes an operation for defining an initial tier and one or more additional tiers for play of the online slots game during the session, each tier being assigned an odds value that changes with each assigned tier, and each tier being defined to have a set of spins. Further, the method includes operations for assigning tiers with changed odds when an option to play a bonus game is not presented during the predefined set of spins for each tier, and for assigning the initial tier upon determining that the bonus game was played during the session.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

Abstract: Facilitation of monitoring and analysis of user motion is performed to facilitate detecting when a user has fallen. A device can comprise a housing configured to attach to a body part of a human, a sensor module configured to capture motion data corresponding to motion of an object to which the device is attached, and a communication module configured to communicatively couple the sensor module to another device and transmit the motion data to the other device, wherein the motion data is configured to be analyzed by the other device to determine a type of the motion of the object, and in response to a determination that the type of motion is a falling motion, the other device is configured to activate a notification mechanism to notify an entity that the human has fallen.

Abstract: Provided are a method and system for implementing alarms for a medical device through a mobile device. The method includes: storing details of examination of a specimen (hereinafter, referred to as examination details) in the medical device, wherein the storing is performed by the medical device; accessing the medical device and establishing a connection with the medical device, wherein the accessing and the establishing of the connection is performed by the mobile device; reading the examination details stored in the medical device, wherein the reading is performed by the mobile device; analyzing the read examination details, wherein the analyzing is performed by the mobile device; and implementing an alarm if the result of analysis satisfies a predetermined criterion, wherein the implementing is performed by the mobile device.

Abstract: An ultrasound diagnosis apparatus which is connectable to a wireless probe that acquires first data by scanning an object is provided. The ultrasound diagnosis apparatus includes a controller which is configured to recognize an occurrence of a first event, to automatically terminate a first communication connection to the wireless probe via a first communication network, and to control an automatic start of a second communication connection to an external apparatus via the first communication network; and a communicator which is configured to exchange data with the wireless probe and/or with the external apparatus by using the first communication network under the control of the controller.

Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

Abstract: Methods, systems, and computer programs are presented for adjusting bonus winning odds while playing an online slots game. One method includes an operation for receiving user input during a session of an online slots game, where the user input is defined to spin wheels of the online slots game. In addition, the method includes an operation for defining an initial tier and one or more additional tiers for play of the online slots game during the session, each tier being assigned an odds value that changes with each assigned tier, and each tier being defined to have a set of spins. Further, the method includes operations for assigning tiers with changed odds when an option to play a bonus game is not presented during the predefined set of spins for each tier, and for assigning the initial tier upon determining that the bonus game was played during the session.

Abstract: Provided are a method and system for implementing alarms for a medical device through a mobile device. The method includes: storing details of examination of a specimen (hereinafter, referred to as examination details) in the medical device, wherein the storing is performed by the medical device; accessing the medical device and establishing a connection with the medical device, wherein the accessing and the establishing of the connection is performed by the mobile device; reading the examination details stored in the medical device, wherein the reading is performed by the mobile device; analyzing the read examination details, wherein the analyzing is performed by the mobile device; and implementing an alarm if the result of analysis satisfies a predetermined criterion, wherein the implementing is performed by the mobile device.

Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

Abstract: Methods, systems, and computer programs are presented for adjusting bonus winning odds while playing an online slots game. One method includes an operation for receiving user input during a session of an online slots game, where the user input is defined to spin wheels of the online slots game. In addition, the method includes an operation for defining an initial tier and one or more additional tiers for play of the online slots game during the session, each tier being assigned an odds value that changes with each assigned tier, and each tier being defined to have a set of spins. Further, the method includes operations for assigning tiers with changed odds when an option to play a bonus game is not presented during the predefined set of spins for each tier, and for assigning the initial tier upon determining that the bonus game was played during the session.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.