Abstract: Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(?)-EGCG]. Use of Pro-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.

Abstract: This invention relates to bis-flavonoid compounds, their synthesis and use for inhibiting multidrug resistance in chemotherapy and protozoan infection, wherein the bis-flavonoids compounds have the formula:

Abstract: Methods, systems, and computer programs are presented for adjusting bonus winning odds while playing an online slots game. One method includes an operation for receiving user input during a session of an online slots game, where the user input is defined to spin wheels of the online slots game. In addition, the method includes an operation for defining an initial tier and one or more additional tiers for play of the online slots game during the session, each tier being assigned an odds value that changes with each assigned tier, and each tier being defined to have a set of spins. Further, the method includes operations for assigning tiers with changed odds when an option to play a bonus game is not presented during the predefined set of spins for each tier, and for assigning the initial tier upon determining that the bonus game was played during the session.

Abstract: A sampling front-end for analog to digital converter is presented that shares a high speed N-bit ADC at front-end and interleaves the pipelined residue amplification with shared amplifier, which achieves high speed, low power and compact area with high density capacitive DAC structure.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: A method for building an application installation repository is disclosed herein. In one embodiment a build directory comprising a plurality of application objects is evaluated. Artifact generation rules may also be evaluated with respect to the application objects and the build directory. Object groupings, each comprising one or more application objects of the plurality of application objects, are defined according to the evaluations of the artifact generation rules and the hierarchical directory structure and artifacts are generated according to the object groupings. An installable application is generated that includes the generated artifacts. Artifacts may be further grouped into sharable units and assemblies according to rules and organization of application objects in the build directory. A delta build including only artifacts corresponding to modified files and correspondingly modified metadata may also be generated according to methods disclosed herein.

Abstract: A method for building an application installation repository is disclosed herein. In one embodiment a build directory comprising a plurality of application objects is evaluated. Artifact generation rules may also be evaluated with respect to the application objects and the build directory. Object groupings, each comprising one or more application objects of the plurality of application objects, are defined according to the evaluations of the artifact generation rules and the hierarchical directory structure and artifacts are generated according to the object groupings. An installable application is generated that includes the generated artifacts. Artifacts may be further grouped into sharable units and assemblies according to rules and organization of application objects in the build directory. A delta build including only artifacts corresponding to modified files and correspondingly modified metadata may also be generated according to methods disclosed herein.

Abstract: Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.

Abstract: A sampling front-end for analog to digital converter is presented that shares a high speed N-bit ADC at front-end and interleaves the pipelined residue amplification with shared amplifier, which achieves high speed, low power and compact area with high density capacitive DAC structure.

Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

Abstract: A comparator is provided and the comparator includes a comparing input unit and a latching unit. Wherein, the comparing input unit has a first input receiving a first comparing signal and has a second input receiving a second comparing signal. The comparing input unit drives a first intermediate node signal at a first intermediate node depending on the first comparing signal according to a first strobe signal, and the comparing input unit drives a second intermediate node signal at a second intermediate node depending on the second comparing signal according to the first strobe signal. The latching unit determines a comparing result according to at least one of the first intermediate node signal and the second intermediate node signal. In addition, the latching unit latches the comparing result according to a second strobe signal.

Abstract: Provided are a method and system for implementing alarms for a medical device through a mobile device. The method includes: storing details of examination of a specimen (hereinafter, referred to as examination details) in the medical device, wherein the storing is performed by the medical device; accessing the medical device and establishing a connection with the medical device, wherein the accessing and the establishing of the connection is performed by the mobile device; reading the examination details stored in the medical device, wherein the reading is performed by the mobile device; analyzing the read examination details, wherein the analyzing is performed by the mobile device; and implementing an alarm if the result of analysis satisfies a predetermined criterion, wherein the implementing is performed by the mobile device.

Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

Abstract: A comparator is provided and the comparator includes a comparing input unit and a latching unit. Wherein, the comparing input unit has a first input receiving a first comparing signal and has a second input receiving a second comparing signal. The comparing input unit drives a first intermediate node signal at a first intermediate node depending on the first comparing signal according to a first strobe signal, and the comparing input unit drives a second intermediate node signal at a second intermediate node depending on the second comparing signal according to the first strobe signal. The latching unit determines a comparing result according to at least one of the first intermediate node signal and the second intermediate node signal. In addition, the latching unit latches the comparing result according to a second strobe signal.

Abstract: Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.

Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

Abstract: The present invention provides a pipelined-successive approximation register (SAR) analog-to-digital converter (ADC) circuit with decoupled flip-around MDAC, capacitive attenuation solution and self-embedded offset cancellation. The flip-around MDAC architecture is built for low inter-stage gain implementation. A capacitive attenuation solution is provided for minimizing the power dissipation and optimizing conversion speed. The design reuses SAR ADC to perform offset cancellation, which significantly saves calibration area, power and time.

Abstract: A method for building an application installation repository is disclosed herein. In one embodiment a build directory comprising a plurality of application objects is evaluated. Artifact generation rules may also be evaluated with respect to the application objects and the build directory. Object groupings, each comprising one or more application objects of the plurality of application objects, are defined according to the evaluations of the artifact generation rules and the hierarchical directory structure and artifacts are generated according to the object groupings. An installable application is generated that includes the generated artifacts. Artifacts may be further grouped into sharable units and assemblies according to rules and organization of application objects in the build directory. A delta build including only artifacts corresponding to modified files and correspondingly modified metadata may also be generated according to methods disclosed herein.

Abstract: A method for building an application installation repository is disclosed herein. In one embodiment a build directory comprising a plurality of application objects is evaluated. Artifact generation rules may also be evaluated with respect to the application objects and the build directory. Object groupings, each comprising one or more application objects of the plurality of application objects, are defined according to the evaluations of the artifact generation rules and the hierarchical directory structure and artifacts are generated according to the object groupings. An installable application is generated that includes the generated artifacts. Artifacts may be further grouped into sharable units and assemblies according to rules and organization of application objects in the build directory. A delta build including only artifacts corresponding to modified files and correspondingly modified metadata may also be generated according to methods disclosed herein.

Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.