Abstract: A multiprocessor system comprises at least one processing module, at least one I/O module, and an interconnect network to connect the at least one processing module with the at least one input/output module. In an example embodiment, the interconnect network comprises at least two bridges to send and receive transactions between the input/output modules and the processing module The interconnect network further comprises at least two crossbar switches to route the transactions over a high bandwidth switch connection. Using embodiments of the interconnect network allows high bandwidth communication between processing modules and I/O modules Standard processing module hardware can be used with the interconnect network without modifying the BIOS or the operating system. Furthermore, using the interconnect network of embodiments of the present invention is non-invasive to the processor motherboard. The processor memory bus, clock, and reset logic all remain intact.

Abstract: A sterilization system includes a sterilization chamber, a vacuum pump associated with the sterilization chamber, a vaporizer in association with the sterilization chamber, a sterilant distillation system associated with the chamber, a source of sterilant solution associated with the vaporizer and with the sterilant distillation system, and a control system which has programmed therein a first cycle in which the sterilant is admitted to the sterilization chamber at a first concentration, and a second cycle in which sterilant is concentrated in the sterilant distillation system to a second concentration, higher than the first concentration and from there admitted into the sterilization chamber and wherein the first and second cycles are selectable.

Abstract: A method for monitoring a cleaning process for a medical instrument, includes the steps of placing the instrument in a cleaning chamber; placing a soil standard in the cleaning chamber; cleaning the instrument and the soil standard with a cleaning solution; and detecting whether soil remains on said soil standard. The soil standard includes two substantially parallel substrates separated with two substantially equal thickness spacers, wherein a gap is formed between the two substrates with soil in the gap.

Abstract: The invention provides a cache management system comprising in various embodiments pre-load and pre-own functionality to enhance cache efficiency in shared memory distributed cache multiprocessor computer systems. Some embodiments of the invention comprise an invalidation history table to record the line addresses of cache lines invalidated through dirty or clean invalidation, and which is used such that invalidated cache lines recorded in an invalidation history table are reloaded into cache by monitoring the bus for cache line addresses of cache lines recorded in the invalidation history table. In some further embodiments, a write-back bit associated with each L2 cache entry records when either a hit to the same line in another processor is detected or when the same line is invalidated in another processor's cache, and the system broadcasts write-backs from the selected local cache only when the line being written back has a write-back bit that has been set.

Abstract: A multiprocessor system comprises at least one processing module, at least one I/O module, and an interconnect network to connect the at least one processing module with the at least one input/output module. In an example embodiment, the interconnect network comprises at least two bridges to send and receive transactions between the input/output modules and the processing module The interconnect network further comprises at least two crossbar switches to route the transactions over a high bandwidth switch connection. Using embodiments of the interconnect network allows high bandwidth communication between processing modules and I/O modules Standard processing module hardware can be used with the interconnect network without modifying the BIOS or the operating system. Furthermore, using the interconnect network of embodiments of the present invention is non-invasive to the processor motherboard. The processor memory bus, clock, and reset logic all remain intact.

Abstract: The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

Abstract: A method of sterilizing an article includes placing the article into a chamber containing an inner atmosphere and exhausting the inner atmosphere to lower pressure in the chamber. Hydrogen peroxide vapor is present in the chamber during at least a portion of the step of exhausting the inner atmosphere. Exhaustion of the inner atmosphere is terminated and additional hydrogen peroxide is admitted into the chamber. Hydrogen peroxide vapor contacts the article for a sufficient period to effect sterilization of the article.

Abstract: The invention provides a cache management system comprising in various embodiments pre-load and pre-own functionality to enhance cache efficiency in shared memory distributed cache multiprocessor computer systems. Some embodiments of the invention comprise an invalidation history table to record the line addresses of cache lines invalidated through dirty or clean invalidation, and which is used such that invalidated cache lines recorded in an invalidation history table are reloaded into cache by monitoring the bus for cache line addresses of cache lines recorded in the invalidation history table. In some further embodiments, a write-back bit associated with each L2 cache entry records when either a hit to the same line in another processor is detected or when the same line is invalidated in another processor's cache, and the system broadcasts write-backs from the selected local cache only when the line being written back has a write-back bit that has been set.

Abstract: Disclosed is a method for microelectrogravimetrically depositing an electroactive species onto an electrode or a plurality of electrodes comprising dispensing a solution containing the electroactive species from a microdispenser to form a hanging drop of the solution and contacting the electrode with the hanging drop of the solution, wherein the electrode is electrically coupled with the microdispenser to form an electrochemical cell, and applying a potential to the electrochemical cell. The application of the potential effects deposition of the electroactive species onto the electrode. The method of the invention eliminates the need for immersion of the electrode in a bath, reduces the volume of solution required by a factor of at least 10-100, and avoids uneven depletion of various components of the solution over successive applications.

Abstract: A method for sterilizing a device, includes the following steps: placing the article into a chamber containing an inner atmosphere; placing a solution comprising hydrogen peroxide and water into fluid communication with the chamber, the solution having a ratio of hydrogen peroxide to water; vaporizing the solution in the inner atmosphere to form water vapor and hydrogen peroxide vapor; selectively drawing water vapor from the chamber to increase a ratio of hydrogen peroxide to water in the chamber; and contacting the article with the hydrogen peroxide vapor.

Abstract: The invention provides a cache management system comprising in various embodiments pre-load and pre-own functionality to enhance cache efficiency in shared memory distributed cache multiprocessor computer systems. Some embodiments of the invention comprise an invalidation history table to record the line addresses of cache lines invalidated through dirty or clean invalidation, and which is used such that invalidated cache lines recorded in an invalidation history table are reloaded into cache by monitoring the bus for cache line addresses of cache lines recorded in the invalidation history table. In some further embodiments, a write-back bit associated with each L2 cache entry records when either a hit to the same line in another processor is detected or when the same line is invalidated in another processor's cache, and the system broadcasts write-backs from the selected local cache only when the line being written back has a write-back bit that has been set.

Abstract: A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.

Abstract: A chemical vapor sterilization process is enhanced by concentrating a germicide via exploitation of the difference between the vapor pressures of the germicide and its solvent. A diffusion restriction can be placed into the diffusion path to assist this process and the path then opened to provide rapid diffusion of the thus concentrated germicide.

Abstract: The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide inside of a sterilization chamber and sterilizing articles therewith. The sterilant is concentrated by removing more water from the sterilization chamber than peroxide.

Abstract: The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide inside of a sterilizer and sterilizing articles therewith. This concentrating process is monitored by determining the concentrations of water and peroxide in the chamber.

Abstract: An apparatus for monitoring a cleaning process for a medical device includes a cleaning chamber for receiving and cleaning the instrument with a cleaning liquid, a receiving well within the cleaning chamber, a removable soil standard receivable within the receiving well whereby to be exposed to the cleaning process within the cleaning chamber; and a soil detector coupled to the cleaning chamber and adapted to provide an indication of the amount of the soil on the soil standard while the soil standard is received within the receiving well.

Abstract: A method for determining and sterilizing a load in a sterilization chamber. A small amount of sterilant is introduced into the sterilization chamber and the concentration of sterilant is measured. The load of equipment to be sterilized is determined from the concentration of sterilant, and more sterilant is added, if necessary, based on the load. The process is repeated, if necessary, until the load is sterilized. The sterilant is preferably hydrogen peroxide, and the concentration of hydrogen peroxide is preferably determined by a spectrophotometric method in the infrared or ultraviolet regions. By monitoring the sterilant concentration and adding more as needed, the equipment in the chamber can be sterilized efficiently without exposing it to high concentrations of sterilant which could damage the equipment or leave too much residual on the equipment.

Abstract: Various forms of apparatus and methods for pretreating and sterilizing a lumen with a peroxide solution prior to sterilization of the interior of the lumen by exposing the lumen to reduced pressure and, optionally, plasma in a sterilization chamber. The pretreatment is preferably done before placing the lumen in the sterilization chamber. The method also includes exposure of the exterior of the lumen to peroxide vapor to sterilize the exterior of the lumen. Pretreatment of the interior of the lumen with liquid peroxide greatly improves the efficiency of sterilization of the interior. Exposure of the lumen to plasma reduces the time required for sterilization.

Abstract: A device, and its production method, the device has a substrate and a coating composition, the coating composition being formed by the gas phase or plasma polymerization of a gas comprising at least one organic compound or monomer. The polymerization is carried out using a pulsed discharge having a duty cycle of less than about ⅕, in which the pulse-on time is less than about 100 msec and the pulse-off time is less than about 2000 msec. The duty cycle can also be varied, thus the coating composition can be gradient layered accordingly. The device has a coating composition which is uniform in thickness, pin-hole free, optically transparent in the visible region of the magnetic spectrum, permeable to oxygen, abrasive resistant, wettable and biologically non-fouling.

Abstract: A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.