Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

Abstract: A telescopic strut, in particular for a device for lifting loads, in particular for a hanger for vehicles or vehicle parts, wherein the telescopic strut consists of an outer tube and an inner tube guided therein, wherein the inner tube is movable longitudinal direction in the outer tube, where a number of sliding shoes are attached to the outer tube to guide the inner tube, where the sliding shoes have each been introduced from the outside into an opening in the wall of the outer tube and protrude inwardly to guide the inner tube such that the telescopic strut, which is structurally simple and therefore inexpensive to produce, has good sliding properties, has little guide play and is easy to maintain.

Abstract: The invention provides a drug mixing and injection system, in particular an adapter for said system enabling the preparation of drug formulations. In a first aspect, the invention relates to an adapter for a drug mixing and injection system comprising a first subunit (110) adapted to hold a vial (113) and a reservoir (115) with injectable liquid, a second subunit (120) comprising a valve (115) and an outlet port (122), at least one internal adapter channel (131), a first cannula (134) between the vial (113) and the internal adapter channel (131), wherein the adapter (100) has a resting position and an activated position. In another aspect, the invention relates to a drug mixing and injection system (200) comprising the adapter of the first aspect of the invention, a vial and a reservoir with injectable liquid.

Abstract: It is provided a method, comprising determining, for plural data pairs each comprising a respective one of a downlink traffic volume of a cell and a downlink traffic bitrate of the cell and a related downlink utilization of the cell, a correlation between the one of the downlink traffic volumes and the downlink traffic bitrates and the downlink utilizations; checking if the correlation is smaller than a predetermined correlation threshold; deciding that the cell is a problematic cell if the correlation is smaller than the correlation threshold.

Abstract: Various embodiments disclosed relate to economic thermally conductive coatings. The present invention includes metal coatings suitable for use with luminaires that facilitate heat dissipation.

Abstract: It is provided a method, comprising determining, for plural data pairs each comprising a respective one of a downlink traffic volume of a cell and a downlink traffic bitrate of the cell and a related downlink utilization of the cell, a correlation between the one of the downlink traffic volumes and the downlink traffic bitrates and the downlink utilizations; checking if the correlation is smaller than a predetermined correlation threshold; deciding that the cell is a problematic cell if the correlation is smaller than the correlation threshold.

Abstract: A system and a method for monitoring at least one blood parameter of blood of different patients, comprising a plurality of access devices for establishing at least one access to the blood of each patient through skin, a plurality of removal devices for removing a quantity of the blood from each patient in order to obtain at least one blood sample, at least one blood analysis device for analyzing the at least one blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of the different patients for calculating data sets of drug parameters of drugs to be administered to a respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying a respective drug having the calculated data sets of the drug parameters.

Abstract: A belt-stripper module for a conveyor belt includes a stripping body. The stripping body includes a cutter carrier, a stripping blade attached thereto and a stripping edge unit attached to the stripping blade. The cutter carrier is rotatable about a stripping-body axis of rotation. The stripping edge unit is positionable so as to form an obtuse angle ? relative to the conveyor belt in a running direction of the conveyor belt and to rest against the conveyor belt at an acute angle ?, as measured at a right angle to the running direction and as seen in direction of the belt surface. The stripping-body axis of rotation intersects the stripping edge unit of the stripping blade at a point of intersection. A stripping-body pivot axis connecting the base and stripping body, as seen in the running direction, is located in front of the point of intersection.

Abstract: A seatbelt pretensioner is provided including an inner tube with a gas generator housed therein, an intermediate sleeve extending over the inner tube, and a spool portion housing the sleeve and the tube. The spool portion includes spiraling flutes thereon that correspond to a protruding member in the form of flutes or pegs extending from the intermediate sleeve. In response to the gas generator firing, the sleeve will be driven longitudinally, causing the protruding member to act on the spiraling flutes of the spool, thereby causing the spool to rotate. The intermediate sleeve can include a spiraling slot that receives a peg from the inner tube, so that the intermediate sleeve will rotate to compound the spool rotation.

Abstract: A belt-stripper module for a conveyor belt includes a stripping body. The stripping body includes a cutter carrier, a stripping blade attached thereto and a stripping edge unit attached to the stripping blade. The cutter carrier is rotatable about a stripping-body axis of rotation. The stripping edge unit is positionable so as to form an obtuse angle ? relative to the conveyor belt in a running direction of the conveyor belt and to rest against the conveyor belt at an acute angle ?, as measured at a right angle to the running direction and as seen in direction of the belt surface. The stripping-body axis of rotation intersects the stripping edge unit of the stripping blade at a point of intersection. A stripping-body pivot axis connecting the base and stripping body, as seen in the running direction, is located in front of the point of intersection.

Abstract: A belt stripper module for a stripping device for the return region of conveyor belts, which module is mounted as one of a plurality on a height-adjustable system carrier.

Abstract: The invention relates to a belt retractor with an electromotive winding aid (4) comprising a belt shaft (1) which is pretensioned in the winding-up direction by a spring and is mounted rotatably in a frame (3) of the belt retractor on which a belt strap (2) can be wound up. The electromotive winding aid (4) can be activated as a function of the belt-strap-retraction speed (BRS).

Abstract: A composite radius filler for filling a void space in a skin-stiffener transition assembly, comprising a plurality of rod-shaped roving bundles that are compressed into a predetermined cross sectional radius filler shape, wherein at least one rod-shaped roving bundle of the plurality of rod-shaped roving bundles is twisted around its longitudinal axis. The invention is further related to a method of producing a rod-shaped roving bundle for a composite radius filler.

Abstract: A method for joining parts to be joined which are subject to tolerance in the aerospace sector. The method involves determining the geometric data of a first and second part to be joined, determining the joining gap dimensions of the first and second parts from the determined geometric data and arranging a plurality of shape elements which can be connected together in planar manner in a first region of a surface of the first part. The method moreover comprises application of a first adhesive layer onto the plurality of shape elements and in a second region of the surface of the first part. The method finally involves joining the first and second parts, the first adhesive layer being brought into contact with the surface of the second part. A corresponding apparatus is provided for joining parts which are subject to tolerance in the aerospace sector.

Abstract: A geared turbomachine having a gear unit a drive unit, and output units integrated into a machine train a central large gear with a large gear shaft and at least two pinions with at least two pinion shafts meshing with the large gear. The geared turbomachine has a drive unit coupled to a first pinion shaft of the gear unit via a first clutch. A first output unit is a main compressor processes a first process gas. The first output unit is coupled to the first pinion shaft via a second clutch such that the first output unit is directly operationally connected to the drive unit with transmission of the gear unit remaining the same. A second output unit is a geared compressor to further process the gas. The second output unit is connected to at least one further pinion shaft of the gear unit in a rotationally fixed manner.

Abstract: The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibition and anti-CD20 agents for the treatment of autoimmune diseases. One preferred method is where the BLyS antagonist is a Fc-fusion protein which can be a TACI-Fc-fusion protein comprising the extracellular domain of TACI or a functional fragment thereof, a BAFF-R-Fc-fusion protein comprising the extracellular domain of BAFF-R or a functional fragment thereof, or a BCMA-Fc-fusion protein comprising the extracellular domain of BCMA or a functional fragment thereof. In the methods of the present invention some of anti-CD20 agents contemplated include RITUXAN®, ocrelizumab, ofatumumab (HuMax-CD20®), TRU-015, and DXL625, although any agent that binds to CD 20 may be suitable. The methods of the present invention reduce the levels of B cells in patients in need of such reduction, such as those suffering from autoimmune diseases.

Abstract: A belt stripper module for a stripping device for the return region of conveyor belts, which module is mounted as one of a plurality on a height-adjustable system carrier.

Abstract: The invention relates to a belt retractor with an electromotive winding aid (4) comprising a belt shaft (1) which is pretensioned in the winding-up direction by a spring and is mounted rotatably in a frame (3) of the belt retractor on which a belt strap (2) can be wound up. The electromotive winding aid (4) can be activated as a function of the belt-strap-retraction speed (BRS).

Abstract: The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibition and anti-CD20 agents for the treatment of autoimmune diseases. One preferred method is where the BLyS antagonist is a Fc-fusion protein which can be a TACI-Fc-fusion protein comprising the extracellular domain of TACI or a functional fragment thereof, a BAFF—R-Fc-fusion protein comprising the extracellular domain of BAFF—R or a functional fragment thereof, or a BCMA-Fc-fusion protein comprising the extracellular domain of BCMA or a functional fragment thereof. In the methods of the present invention some of anti-CD20 agents contemplated include RITUXAN®, (rituximab),ocrelizumab, ofatumumab (HuMax-CD20®), TRU-015, and DXL625, although any agent that binds to CD 20 may be suitable. The methods of the present invention reduce the levels of B cells in patients in need of such reduction, such as those suffering from autoimmune diseases.

Abstract: The present invention relates to aqueous polyurethane dispersions for sealing teats of animal mammary glands.