Patents by Inventor Hans-Peter Josel

Hans-Peter Josel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050176014
    Abstract: The invention is directed to a pair of FRET hybridization probes consisting of a first oligonucleotide carrying a FRET donor entity and a second oligonucleotide carrying a FRET acceptor entity, wherein said first oligonucleotide carrying the donor fluorescent entity is carrying at least one second entity, said second entity being a compound which is capable of quenching fluorescence emission of said donor fluorescent entity. In addition, the invention is directed to methods of using the same.
    Type: Application
    Filed: July 16, 2003
    Publication date: August 11, 2005
    Applicant: ROCHE MOLECULAR SYSTEMS, INC
    Inventors: Dieter Heindl, Hans-Peter Josel, Gregor Sagner, Jutta Mayr
  • Patent number: 6908769
    Abstract: The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the resulting fluorescence. The invention also concerns the use of these dyes to label biomolecules and for the homogeneous determination of interactions between biomolecules, for example for detecting an analyte.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: June 21, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Daniel Belik, Hans-Peter Josel, Rupert Herrmann, Bernard Koenig, Francis Mueller
  • Publication number: 20050042618
    Abstract: Compositions, reaction mixtures, and kits, as well as methods for their use, comprising a pair of FRET hybridization probes hybridizing adjacently to a target nucleic acid sequence, each hybridization probe comprising (i) a nucleotide sequence entity which is substantially complementary to the sequence of the target nucleic acid, (ii) a fluorescent entity, being either a FRET donor entity or a FRET acceptor entity, and (iii) a spacer entity connecting the nucleotide sequence entity and the fluorescent entity. The intensity of fluorescence emission from the FRET donor entity and from the FRET acceptor entity is not substantially affected by quenching activity of nucleotide residues present in the sequence of the target nucleic acid or in the nucleotide sequence entities of the hybridization probes.
    Type: Application
    Filed: August 6, 2003
    Publication date: February 24, 2005
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Dieter Heindl, Hans-Peter Josel, Gregor Sagner, Ingrid Bechler
  • Publication number: 20040248225
    Abstract: The present invention relates to substituted hydrazides of a luciferin dye or to substituted hydrazides of a dye analogous thereto. These chemical compounds comprise the luciferin dye or the dye analogue thereto as a light emitting moiety precursor and the substituted hydrazide as a leaving group precursor, wherein a nitrogen atom of said hydrazide group is bound to a carbonyl group or to a group chemically equivalent to said carbonyl group of said luciferin or said analogue. The invention also relates to conjugates between a biomolecule and these compounds and to the use of such compounds in chemiluminescence procedures.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 9, 2004
    Inventors: Dieter Heindl, Rupert Herrmann, Hans-Peter Josel, Erasmus Huber, Ursula Klause, Oliver Simon
  • Publication number: 20040234945
    Abstract: The invention concerns methods and reagent kits for the fluorimetric determination of analytes.
    Type: Application
    Filed: January 28, 2004
    Publication date: November 25, 2004
    Inventors: Carina Horn, Hans-Peter Josel, Jurgen Spinke, Rupert Herrmann, Dieter Heindl
  • Publication number: 20040214999
    Abstract: The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.
    Type: Application
    Filed: June 14, 2004
    Publication date: October 28, 2004
    Inventors: Dieter Heindl, Rupert Herrmann, Hans-Peter Josel, Erasmus Huber, Ursula Klause
  • Publication number: 20040191794
    Abstract: The present invention is directed to a method for the determination of at least 3 analytes using specific binding partners. Combinations of detectable labels are coupled to the binding partners assuring that each binding partner molecule is coupled with only one detectable label. This allows the determination of more different analytes than different labels used by not limiting the range of useable labels. The present invention is also related to kits, composition of matters and their use.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 30, 2004
    Inventors: Kurt Weindel, Stefan Kraiss, Frank Bergmann, Hans-Peter Josel, Dieter Heindl
  • Publication number: 20040086943
    Abstract: The present invention concerns new compounds comprising a branched linker and their use for producing conjugates for applications in diagnostic or therapeutic methods.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Inventors: Herbert Andres, Hans-Peter Josel, Eva Hoess, Rupert Hermann, Herbert Von Der Eltz
  • Publication number: 20040076979
    Abstract: The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the resulting fluorescence. The invention also concerns the use of these dyes to label biomolecules and for the homogeneous determination of interactions between biomolecules, for example for detecting an analyte.
    Type: Application
    Filed: October 24, 2003
    Publication date: April 22, 2004
    Inventors: Daniel Belik, Hans-Peter Josel, Rupert Hermann, Bernard Koenig, Francis Mueller
  • Patent number: 6716640
    Abstract: The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: April 6, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Gabriele Punzmann, Martin Egger, Hans-Peter Josel
  • Patent number: 6689616
    Abstract: New dye-polysaccharide and dye-cyclosaccharide conjugates and their use as a diagnostic agent especially for determining the glomerular filtration rate in humans.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: February 10, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Elmar Bosies, Heinz-Michael Hein, Rudolf Reiter, Hans Peter Josel
  • Publication number: 20040023289
    Abstract: A method is disclosed for obtaining and/or immunologically detecting an analyte contained in a gas phase by immunologically binding the analyte to a binding partner thereof contained in a gas- and liquid-permeable first carrier matrix.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 5, 2004
    Applicant: Securetec Detektions-Systeme AG
    Inventors: Christian Klein, Hans-Peter Josel, Rupert Herrmann, Josef Maier, Harald Ertl, Helmut Oberpriller, Reinhold Hilpert, Florian Binder, Josef Ritter
  • Publication number: 20030224421
    Abstract: The invention concerns new oxazine derivatives of the general formula I 1
    Type: Application
    Filed: April 3, 2003
    Publication date: December 4, 2003
    Inventors: Rupert Herrmann, Hans-Peter Josel, Karl-Heinz Drexhage, Nicolaas-Joseph Marx
  • Patent number: 6605444
    Abstract: A method is disclosed for obtaining and/or immunologically detecting an analyte contained in a gas phase by immunologically binding the analyte to a binding partner thereof contained in a gas- and liquid-permeable first carrier matrix. Said method is characterized in that a) the analyte-containing gas phase is brought into contact with the first carrier matrix (immune adsorber), b) the analyte is bound to the first binding partner which is contained in the first matrix and not bound to the matrix, and c) the complex of analyte and first binding partner and the free first binding partner are eluted from the first matrix, d) the eluted complex or the free first binding partner is determined as a measure for the amount of analyte present.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: August 12, 2003
    Assignees: Securetec Detektions-Systems AG, Deutsche Aerospace AG
    Inventors: Christian Klein, Hans-Peter Josel, Rupert Herrmann, Josef Maier, Harald Ertl, Helmut Oberpriller, Reinhold Hilpert, Florian Binder, Josef Ritter
  • Patent number: 6514773
    Abstract: Subject matter of the invention is a method for detecting surface contamination by an analyte by wiping the analyte off the surface with the aid of a wiping surface, eluting the analyte from the wiping surface with an eluant, and detecting the analyte in the eluate in an immunological detection reaction, characterized in that: a) the surface to be tested for the analyte is wiped with a wiping surface, b) the wiping surface is brought into contact with the planar surface of a capillary active, chromatographic test strip which has an eluant application zone at its one end and a target zone at its other end whereby contact is made in an area between these two zones, c) eluting liquid is applied onto the zone provided for this purpose, said liquid moving toward the target zone passes the contact site with the wiping surface as a consequence of capillary forces, whereby analyte is taken up by the eluant, and d) in the target zone, the analyte is measured in an immunological binding reaction.
    Type: Grant
    Filed: July 24, 1995
    Date of Patent: February 4, 2003
    Assignee: Securetec Detektions-Systeme AG
    Inventors: Christian Klein, Hans-Peter Josel, Ada Goerlach-Graw, Reinhold Hilpert, Florian Binder, Josef Ritter, Rudolf Zimmermann
  • Patent number: 6432722
    Abstract: The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
    Type: Grant
    Filed: March 15, 1999
    Date of Patent: August 13, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Gabriele Punzmann, Martin Egger, Hans-Peter Josel
  • Patent number: 6340742
    Abstract: Erythropoietin glycoprotein products are disclosed which have the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells. The present conjugates have an increased circulating half-life and plasma residence time, decreased clearance, and increased clinical activity in vivo. In addition, compared with conventional PEG-EPO conjugates, the conjugates of this invention have superior clinical properties. The present invention also includes a method for the treatment of anemia in a human employing the novel erythropoietin glycoprotein products as well as a method for preparing the erythropoietin glycoprotein products.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: January 22, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Josef Burg, Bernd Hilger, Hans-Peter Josel
  • Publication number: 20010036673
    Abstract: The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 1, 2001
    Inventors: Gabriele Punzmann, Martin Egger, Hans-Peter Josel
  • Publication number: 20010021503
    Abstract: The present invention concerns new conjugates, processes for their production as well as the use of these conjugates as antigens in immunological detection methods or for DNA diagnostics.
    Type: Application
    Filed: March 7, 2001
    Publication date: September 13, 2001
    Applicant: Boehringer Mannheim GmbH (4pp)
    Inventors: Hans-Peter Josel, Andreas Finke, Rupert Herrmann, Eva Hoss, Andreas Marschall, Christoph Seidel
  • Patent number: 6281021
    Abstract: The invention concerns methods for the detection of an analyte in a sample by chemiluminescence or electrochemiluminescence using derivatized test reagents. In addition new reagents and reagent kits for chemiluminescence and electrochemiluminescence detection methods are disclosed.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: August 28, 2001
    Assignee: Roche Diagnostics GmbH
    Inventors: Martin Egger, Hans-Peter Josel, Gabriele Punzmann