Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A traceable device and procedure suitable for investigating gastrointestinal motility disorders by measuring transit time of the device as it is passed through the gastrointestinal tract of a patient. The device includes a core material configured to be imaged with a gamma imaging process and optionally also an x-ray imaging process, and a sealing material substantially insoluble in gastrointestinal fluids and fully encapsulating the core material.

Abstract: A traceable device and procedure suitable for investigating gastrointestinal motility disorders by measuring transit time of the device as it is passed through the gastrointestinal tract of a patient. The device includes a core material configured to be imaged with a gamma imaging process and optionally also an x-ray imaging process, and a sealing material substantially insoluble in gastrointestinal fluids and fully encapsulating the core material.

Abstract: The process relates to a process for preparing delta-valerolactone (VLO) in the gas phase by catalytic dehydrogenation over at least two different catalysts.

Abstract: The process relates to a process for preparing delta-valerolactone (VLO) in the gas phase by catalytic dehydrogenation over at least two different catalysts.

Abstract: A method of directional drilling which comprises an intelligent non-invasive ultrasonic sensors that can detect the approaching of an existing well and then can stop and redirect the directional drilling to prevent collisions with preexisting wells.

Abstract: Disclosed is a method for producing cyclic phosphonic acid anhydrides of formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.

Abstract: The invention relates to a method for producing melem-free melamine by means of aqueous processing of a melted mass of melamine which is obtained using a high-pressure method. According to the inventive method, the melted mass of melamine is quenched by means of an aqueous solution containing alkalis, following the isolation of the off-gases, and is directly transferred into an aqueous alkaline melamine solution, out of which the melamine is then crystallized. The invention thus enables melamine to be obtained, with a melam content of less than 1000 ppm and a melem content of less than 50 ppm. The invention also relates to a quenching agent.

Abstract: A continuous process for the production of thermoplastically processable polyurethane elastomer is disclosed. The process comprise adding acid H compounds in an amount calculated to control and render constant the melt viscosity of the product. The inventive elastomer has constant melt flow behavior and high thermal stability.

Abstract: A continuous process for the production of thermoplastically processable polyurethane elastomer is disclosed. The process comprise adding acid H compounds in an amount calculated to control and render constant the melt viscosity of the product. The inventive elastomer has constant melt flow behavior and high thermal stability.

Abstract: A needle tipped with a plating of radioactive metal and covered with additional layers of plating to prevent subsequent rubbing off of radioactive material, decreases local or systemic reactions to the plating materials, and prevents decomposition of the underlying plating materials. The radioactive tipped needle can be used in conjunction with nuclear medicine imaging techniques to identify and localize abnormalities that may not be seen using other radiographic techniques. A method for producing the needle is also described.

Abstract: The invention relates to the continuous production of polyurethane and polyurethane urea prepolymers by reaction of polyisocyanates with isocyanate-reactive compounds in a mixing nozzle.

Abstract: Papermaking machine fabrics, filters and reinforcing layers for elastomers, comprise monofilaments of copolymers containing 85 to 99 mol % of the structural repeat unit of the formula I ##STR1## 1 to 15 mol % of the structural repeat unit of the formula II--OC--R.sup.2 --CO--O--R.sup.3 --O-- (II),whereR.sup.1 is a radical of a dihydric aliphatic or cycloaliphatic alcohol or is derived from mixtures of such alcohols,R.sup.2 is a radical of an aliphatic, cycloaliphatic or monocyclic aromatic dicarboxylic acid or is derived from mixtures of such dicarboxylic acids,R.sup.3 assumes one of the definitions for R.sup.1, and the quantitative data are based on the total amount of the polymer.

Abstract: Abrasion-resistant polyester mixture with enhanced consistency of processing, monofilaments therefrom, and production and use thereof. Described is an abrasion-resistant polyester mixture with enhanced consistency of processing, comprising a thermoplastic polyester and a thermoplastic polyurethane with or without customary nonpolymeric additives, the mixture of said polyester and said polyurethane having a melting point between 200.degree. and 230.degree. C. as are monofilaments made of said mixture.Also described are the production of this abrasion-resistant polyester mixture, the production of monofilaments therefrom, and their use for producing paper machine wire cloths.

Abstract: A respirator is provided with a gas-metering device for respiration gases, a control unit influencing and monitoring the metering of the gas, an input unit connected to the control unit for introducing commands into the control unit, a display unit outputting parameters, a rotary knob changing preselected parameters, and with an acknowledge switch, which takes over the changed parameter as a new set value into the control unit and is actuated by the rotary knob. The display unit is designed as an interactive flat screen with a contact-sensitive surface. Data entry sectors with setting segments and output sectors for parameters to be displayed are provided within the flat screen. The input unit is designed as a keypad arranged on the side of the flat screen. At least preselected data entry sectors on the flat screen can be switched by means of the keypad.

Abstract: A method for work-hardening a component to be loaded along a loading axis includes rolling in a notch extending approximately at right angles to the loading axis. The notch has a minimum radius of curvature to be determined in a cross-section parallel to the loading axis. The notch is work-hardened by rolling along a plurality of tracks being adjacent one another along the loading axis and being directed approximately at right angles to the loading axis, with each track covering only a part of the notch. Compressive internal stresses are generated which have axial components and tangential components relative to the loading axis. The axial components are substantially larger than the tangential components. The method is particularly suitable for work-hardening by rolling of a retention groove in a root part of a turbine blade.

Abstract: The present invention relates to the continuous production of polyurethane and polyurethane urea elastomers by reaction of polyisocyanates with isocyanate-reactive compounds in a mixing nozzle.

Abstract: This invention concerns a method for precipitating polymers from a liquid using at least one precipitant fluid, including a feed line, a nozzle plate having at least one outlet orifice for a polymer containing fluid with the outlet orifice communicating with the feed line, at least one nozzle for at least one precipitant fluid, the axis of which is arranged approximately perpendicularly to the axis of the outlet orifice, a precipitation chamber positioned on the side of the nozzle plate wherein at least one nozzle for at least one precipitant fluid is located, a discharge line for discharging a mixture which contains the precipitated polymer and a degassing chamber which is connected to the discharge line.

Abstract: A device for precipitating polymers from a liquid by at least one precipitant fluid includes a feed line, a nozzle plate having at least one outlet orifice for a polymer containing fluid with the outlet orifice communicating with the feed line, at least one nozzle for at least one precipitant fluid, the axis of which is arranged approximately perpendicularly to the axis of the outlet orifice, a precipitation chamber positioned on the side of the nozzle plate wherein at least one nozzle for at least one precipitant fluid is located, a discharge line for discharging a mixture which contains the precipitated polymer and a degassing chamber which is connected to the discharge line.