Abstract: In a method of identifying novel virulence associated genetic information about a pathogenic microorganism including information about open reading frames (ORFs) having (a) assigned functions, (b) no assigned functions, (c) showing similarity with hypothetical proteins from other species is provided. An obligate human parasite evolutionary deprived of a substantial portion of its coding capacity is selected and genetic information about it is provided. By comparing the genetic information at least one open reading frame (ORF) common to the microorganism and the human parasite is identified, which codes for a protein (c) showing similarity with a hypothetical protein from other microorganism species. By introduction of a mutation in the ORF a mutated ORF is produced. The pathogenicity of the mutated pathogenic organism is assessed and compared with that of the corresponding non-mutated pathogenic organism.

Abstract: A rotor for a tablet press including an upper-ram receptacle for the upper rams and a lower-ram guide for the lower rams of the tablet press, as well as a retainer plate having a series of die-bores which are oriented towards the upper and lower rams wherein the retainer plate is composed of at least two ring segments which are adapted to be mounted non-positively and/or positively to the body of the lower-ram guide by means of a fixing device.

Abstract: The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The present invention further refers to polypeptides encoded by the nucleic acid sequence or the fragment or derivative thereof as depicted in SEQ ID NO:1, 2 or 3. The polynucleotides and polypeptides may be used as medicaments, vaccines or diagnostic substances, preferably for the treatment, prevention or diagnostic of HIV infections.

Abstract: The subject of the present invention is new substances which are derived from naturally occurring ceramides and sphingosine and also from synthetic compounds with principally the same structure in that they represent dimers, trimers, tetramers etc., hence i.e. oligomers of the initial substances.

Abstract: A rotor for a tablet press including an upper-ram receptacle for the upper rams and a lower-ram guide for the lower rams of the tablet press, as well as a retainer plate having a series of die-bores which are oriented towards the upper and lower rams wherein the retainer plate is composed of at least two ring segments which are adapted to be mounted non-positively and/or positively to the body of the lower-ram guide by means of a fixing device.

Abstract: A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca2+, incubating the Ca2+ depleted bacteria with an agent the antibacterial effect of which shall be determined, recording the light emitted by the bacteria upon addition of an aldehyde, the incubation being carried out at a temperature which is at least 10° C. higher than the temperature at which the light is emitted by the bacteria. Also disclosed are corresponding probes and antibacterial agents identified by the method.

Abstract: To be able to realize a relatively wide magnetron sputter cathode, it is proposed that on the vacuum side of a carrier (2) is disposed the sputter target (4) with a backing plate (3), which maintains a gap (14) from the carrier (2). The backing plate (3) is developed as a cooling plate. In it are located cooling means channels (15), which, via an inlet (16) through the carrier (2), are supplied with cooling fluid, which can flow out again via an outlet (17) through the carrier (2). On the atmospheric side is located a magnet configuration (5).

Abstract: Claimed is a sputtering target system comprising a plurality of backing plates (2, 3, 4) to be individually cooled. Each backing plate (2, 3, 4) is provided on its back side with a meandering groove (5) that is closed off by a sealing plate. The sealing plate (9) is welded around its circumference to the backing plate (2), and at the same time is welded to at least one ridge (7), located at a distance from the frame, which separates two grooved sections from one another. The sealing plate thus welded to the backing plate (3) not only closes off the grooves to form a cooling channel, but also is used for reinforcement of the otherwise relatively flat backing plate (20).

Abstract: The invention relates to a method for infiltration of polypeptides in cells. The invention further relates to the use of the cells and urea-adjuvated polypeptides for the diagnosis, treatment or prevention of diseases. The invention further relates to the detection of polypeptide-specific immune cells.

Abstract: A die for a rotary compression press, comprising a die holder axially supported in a guide bore and a die insert which is seated in the end-side bore of the die holder via a trunnion-shaped projection and is adapted to be mounted via releasable fastening means, wherein the projection is helically guided in the bore between axially spaced stops and is biased by a spring towards the associated front-end face of the die holder.

Abstract: A rotary compression press for cylindrical compacts, especially tablets, comprising a rotatably driven rotor including a die-plate and an upper and a lower ram guide for upper and lower rams cooperating with the die bores, and a pressure station with an upper and a lower pressure roller for applying a pressing power to the rams wherein the rams circumferentially have an annular tooth system which cooperates with an opposed tooth system in the area of a pressure station for the rams for the purpose of rotating the rams in the die bores thereof, characterized in that the opposed tooth system is defined by a rotatably supported gear which is acted on by a preset braking torque with the braking torque being chosen so as to be smaller than the torque of the ram when under a maximum pressing power.

Abstract: A rotor for a tablet press including an upper-ram receptacle for the upper rams and a lower-ram guide for the lower rams of the tablet press, as well as a retainer plate having a series of die-bores which are oriented towards the upper and lower rams wherein the retainer plate is composed of at least two ring segments which are adapted to be mounted non-positively and/or positively to the body of the lower-ram guide by means of a fixing device.

Abstract: An operating stand for a tablet press device which comprises a process computer with a screen and an input keyboard and where appropriate a printer, wherein the operating lectern is mounted height-adjustable on a traversable base and between the base and the operating lectern there is arranged a linear adjusting drive with a linear guide.

Abstract: A rotary tabletting machine with a housing, with a matrix disk in the housing, which in an upper and a lower receiving section guides the upper and lower punch, with an upper and lower cam carrier ring rotationally rigid relative to the housing, for control of the upper and lower punch and with an upright drive shaft, below the matrix disk, driven by a rotational drive and releasably connectable to the matrix disk, wherein the matrix disk and the cam carrier rings with the upper and lower punch after release from the connections as an assembly may be commonly removed from the drive shaft, whereby the cam carrier rings laterally in each case are connected to at least one arm and the arms via an upright connection section are rigidly connected to one another and the connection section is releasably couplable to the housing such that it is secured against rotation.

Abstract: A rotary tablet press, with a die plate rotatably mounted in a housing, which comprises guides for the upper and lower punch, whose position is controlled by cam disks rigid with the housing, and with an upright drive shaft which is arranged below the die plate and which can be releasably coupled to the die plate, wherein the die plate is formed such that after releasing from the drive shaft and a slight raising it may be moved out laterally, wherein at the ends, facing one another, of the die plate and drive shaft there is provided a quick locking whose parts are arranged in cavities of the die plate and drive shaft and which may be actuated by an actuation rod which is movably mounted in an axial channel of the drive shaft and is actuatable by an actuation device for the selective tensioning or releasing of the die plate and drive shaft.

Abstract: A die for a rotary compression press, comprising a die holder axially supported in a guide bore and a die insert which is seated in the end-side bore of the die holder via a trunnion-shaped projection and is adapted to be mounted via releasable fastening means, wherein the projection is helically guided in the bore between axially spaced stops and is biased by a spring towards the associated front-end face of the die holder.

Abstract: A device for transporting substrates through a vacuum system has a flat, parallel piped, plate-shaped substrate holder with upper and lower holder areas that are moveable in a vertical position along a transport path through the system. The upper part of the substrate holder is supported without contact and is movably guided by a magnetic arrangement.

Abstract: The invention relates to preparation of selected peptides of the HIV gag protein and derivatives thereof which comprise the peptide sequence NPGLLETSEGCRQ, and which inhibit HIV.

Abstract: A substrate carrier plate (17, 17a) designed to hold at least one substrate is removably attached to a support element (19, 19a) of a base (2). The carrier plate is held to the support element (19, 19a) at least at one point by a centering pin (22, 23; 22a, 23a), which projects from the plate of the support element (19) and fits into a hole (24, 25) in the substrate carrier plate (17), and at least at one other point by a clamping device (18, 18a). The clamping device (18, 18a) is held on a control part (11) on the base (2) in such a way that it can be moved by the displacement of an actuating arm (21) between a clamping position and a release position, and it is also provided with a tensioning roller (14), which is supported on a ramp (15, 15a) on the substrate carrier plate (17). The substrate carrier plate (17) has an opening (20, 20a) to allow the passage of the tensioning roller (14), the tensioning roller (14, 14a) being located behind this opening when in its release position.

Abstract: A live vaccine comprising an avirulent, invasive and immunogenic strain of a fish pathogenic bacterial species is used for immunization of fish against infectious diseases caused by fish pathogens by immersion of the fish into a suspension of the vaccine strain. Suitable strains for the preparation of said vaccine include Vibrio anguillarum strains DSM 4506, DSM 4507 and DSM 4508.